Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use

This is DNA in a nanochannel.

Credit: SISSA
This is DNA in a nanochannel.

Credit: SISSA

Abstract:
With the widespread use of methods for DNA analysis and manipulation, it's certainly useful to find a way to unravel and relax the strands of this molecule that tends to form tangles spontaneously. One way is to use channels, or rather nano-channels, as Cristian Micheletti, SISSA research scientist, and Enzo Orlandini, of Padua University, did in a study just published in the journal Macro Letters.



This is a model DNA chain inside a nanochannel that is 100nm wide. The spontaneous dynamical evolution of the DNA is accompanied by frequent knotting and entanglement at the chain ends.

Credit: SISSA

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use

Trieste, Italy | Posted on August 20th, 2014

The idea is to force the DNA into the channel so as to relax it completely. "But not just any channel will do," explains Micheletti. "Depending on the diameter of the nano-channel, the strand extremities can arrange into hook-like structures that will end up forming a knot".

"In our study we used simulation techniques to characterise the mechanisms leading to knot formation as a function of the diameter of the channel", Micheletti continues.

The result? "Below 50 nanometres in diameter the tendency to form knots decreases dramatically". Thanks to these observations it is possible to design channels having the ideal characteristics for achieving a nicely stretched out DNA strand, free of the entanglements that can hinder many methods for genetic analysis.

####

For more information, please click here

Contacts:
Federica Sgorbissa

0039-040-378-7644

Copyright © International School of Advanced Studies (SISSA)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New pathway to valleytronics January 27th, 2015

Stomach acid-powered micromotors get their first test in a living animal January 27th, 2015

Entanglement on a chip: Breakthrough promises secure communications and faster computers January 27th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

Videos/Movies

Stomach acid-powered micromotors get their first test in a living animal January 27th, 2015

Discoveries

New pathway to valleytronics January 27th, 2015

Stomach acid-powered micromotors get their first test in a living animal January 27th, 2015

Entanglement on a chip: Breakthrough promises secure communications and faster computers January 27th, 2015

Nanoshuttle wear and tear: It's the mileage, not the age January 26th, 2015

Announcements

New pathway to valleytronics January 27th, 2015

Entanglement on a chip: Breakthrough promises secure communications and faster computers January 27th, 2015

Detection of Heavy Metals in Samples with Naked Eye January 26th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

New pathway to valleytronics January 27th, 2015

Stomach acid-powered micromotors get their first test in a living animal January 27th, 2015

Entanglement on a chip: Breakthrough promises secure communications and faster computers January 27th, 2015

Nanoshuttle wear and tear: It's the mileage, not the age January 26th, 2015

Nanobiotechnology

Nanoshuttle wear and tear: It's the mileage, not the age January 26th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

DNA 'glue' could someday be used to build tissues, organs January 14th, 2015

Photonic crystal nanolaser biosensor simplifies DNA detection: New device offers a simpler and potentially less expensive way to detect DNA and other biomolecules through changes in surface charge density or solution pH January 13th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE