Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > On the frontiers of cyborg science

Abstract:
Title

Nanoelectronics meets biology: From new tools to electronic therapeutics

Abstract

Nanoscale materials enable unique opportunities at the interface between the physical and life sciences, and the interfaces between nanoelectronic devices and cells, cell networks, and tissue makes possible communication between these systems at the length scale relevant to biological function. In this presentation, the development of nanowire nanoelectronic devices and their application as powerful tools for the recording and stimulation from the level of single cells to tissue will be discussed. First, a brief introduction to nanowire nanoelectronic devices as well as comparisons to other tools will be presented to illuminate the unique strengths and opportunities enabled by active electronic devices. Second, opportunities for the creation of powerful new probes capable of intracellular recording and stimulation at scales heretofore not possible with existing electrophysiology techniques will be discussed. Third, we will take an 'out-of-the-box' look and consider merging nanoelectronics with cell networks in three-dimensions (3D). We will introduce general methods and provide examples of synthetic 'cyborg' tissues innervated with nanoelectronic sensor elements that enabling recording and modulating activity in 3D for these engineered tissues. In addition, we will discuss extension of these nanoelectronic scaffold concepts for the development of revolutionary probes for acute and chronic brain mapping as well as their potential as future electronic therapeutics. The prospects for broad-ranging applications in the life sciences as the distinction between electronic and living systems is blurred in the future will be discussed.

Selected References

1. B. Tian et al., Nature Mater. 11, 986-994 (2012)

2. X. Duan et al., Nano Today 8, 351-373 (2013)

3. Q. Qing et al., Nature Nanotechnol. 9, 142-147 (2014)

On the frontiers of cyborg science

San Francisco, CA | Posted on August 10th, 2014

No longer just fantastical fodder for sci-fi buffs, cyborg technology is bringing us tangible progress toward real-life electronic skin, prosthetics and ultraflexible circuits. Now taking this human-machine concept to an unprecedented level, pioneering scientists are working on the seamless marriage between electronics and brain signaling with the potential to transform our understanding of how the brain works — and how to treat its most devastating diseases.

Their presentation is taking place at the 248th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society. The meeting features nearly 12,000 presentations on a wide range of science topics and is being held here through Thursday.

"By focusing on the nanoelectronic connections between cells, we can do things no one has done before," says Charles M. Lieber, Ph.D. "We're really going into a new size regime for not only the device that records or stimulates cellular activity, but also for the whole circuit. We can make it really look and behave like smart, soft biological material, and integrate it with cells and cellular networks at the whole-tissue level. This could get around a lot of serious health problems in neurodegenerative diseases in the future."

These disorders, such as Parkinson's, that involve malfunctioning nerve cells can lead to difficulty with the most mundane and essential movements that most of us take for granted: walking, talking, eating and swallowing.

Scientists are working furiously to get to the bottom of neurological disorders. But they involve the body's most complex organ — the brain — which is largely inaccessible to detailed, real-time scrutiny. This inability to see what's happening in the body's command center hinders the development of effective treatments for diseases that stem from it.

By using nanoelectronics, it could become possible for scientists to peer for the first time inside cells, see what's going wrong in real time and ideally set them on a functional path again.

For the past several years, Lieber has been working to dramatically shrink cyborg science to a level that's thousands of times smaller and more flexible than other bioelectronic research efforts. His team has made ultrathin nanowires that can monitor and influence what goes on inside cells. Using these wires, they have built ultraflexible, 3-D mesh scaffolding with hundreds of addressable electronic units, and they have grown living tissue on it. They have also developed the tiniest electronic probe ever that can record even the fastest signaling between cells.

Rapid-fire cell signaling controls all of the body's movements, including breathing and swallowing, which are affected in some neurodegenerative diseases. And it's at this level where the promise of Lieber's most recent work enters the picture.

In one of the lab's latest directions, Lieber's team is figuring out how to inject their tiny, ultraflexible electronics into the brain and allow them to become fully integrated with the existing biological web of neurons. They're currently in the early stages of the project and are working with rat models.

"It's hard to say where this work will take us," he says. "But in the end, I believe our unique approach will take us on a path to do something really revolutionary."

###

Lieber acknowledges funding from the U.S. Department of Defense, the National Institutes of Health and the U.S. Air Force.

####

About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 161,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

For more information, please click here

Contacts:
Michael Bernstein
415-978-3506 (S.F. Press Center, Aug. 9-13)
202-872-6042


Katie Cottingham, Ph.D.
415-978-3506 (S.F. Press Center, Aug. 9-13)
301-775-8455

Copyright © American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Brain-Computer Interfaces

Leti demonstrates world’s first alpha-wave measuring system for consumers at CES Unveiled and at its booth: RELAX Headgear Provides New Dimension to Wellness Management In Every Area of Life, From Working to Studying to Exercising or Just Sitting December 13th, 2016

Peter Diamandis Thinks Nanotech Will Interface With Human Minds September 1st, 2016

New probe developed for improved high resolution measurement of brain temperature: Improved accuracy could allow researchers to measure brain temperature in times of trauma when small deviations in temperature can lead to additional brain injury July 23rd, 2016

Optical magnetic field sensor can detect signals from the nervous system July 19th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

Research reveals novel quantum state in strange insulating materials February 14th, 2017

Nanomedicine

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread: Leading-Edge Research Is Part of National Cancer Moonshot Initiative February 13th, 2017

Meta-lenses bring benchtop performance to small, hand-held spectrometer: Game-changing nanostructure-based lenses allow smaller devices, increased functionality February 9th, 2017

Announcements

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Research opens door to smaller, cheaper, more agile communications tech February 16th, 2017

Military

Engineers shrink microscope to dime-sized device February 17th, 2017

Graphene foam gets big and tough: Rice University's nanotube-reinforced material can be shaped, is highly conductive February 13th, 2017

Meta-lenses bring benchtop performance to small, hand-held spectrometer: Game-changing nanostructure-based lenses allow smaller devices, increased functionality February 9th, 2017

Transparent gel-based robots can catch and release live fish: Made from hydrogel, robots may one day assist in surgical operations, evade underwater detection February 2nd, 2017

Events/Classes

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

National Space Society's Space Settlement Summit Draws Industry Leaders February 4th, 2017

Leti Presents First Results in LED Pixelization & Record Resolution for Micro-Displays at Photonics West February 3rd, 2017

Arrowhead Pharmaceuticals to Webcast Fiscal 2017 First Quarter Results January 31st, 2017

Alliances/Trade associations/Partnerships/Distributorships

Leti Coordinating Project to Adapt Obstacle-Detection Technology Used in Autonomous Cars for Portable and Wearable Systems: INSPEX to Combine Knowhow of Nine European Organizations to Create Portable and Wearable Spatial-Exploration Systems February 2nd, 2017

GLOBALFOUNDRIES Expands Partner Program to Speed Time-to-Market of FDX™ Solutions: Increased support affirms FDXcelerator™ Program’s vital role in promoting broader deployment of GLOBALFOUNDRIES’ FDX™ portfolio December 15th, 2016

Infrared instrumentation leader secures exclusive use of Vantablack coating December 5th, 2016

Leti and Grenoble Partners Demonstrate World’s 1st Qubit Device Fabricated in CMOS Process: Paper by Leti, Inac and University of Grenoble Alpes Published in Nature Communications November 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project