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|Professor Alexander Seifalian and Dr Achala de Mel, co-authors of the 1000th peer-reviewed paper to cite Nanoparticle tracking analysis.|
Malvern Instruments reports on the publication of the 1000th peer-reviewed paper to cite the company's NanoSight Nanoparticle Tracking Analysis, NTA. Entitled "Fumed Silica Nanoparticle Mediated Biomimicry for Optimal Cell-Material Interactions for Artificial Organ Development," it was authored by the research team of Professor Alexander Seifalian from University College London.
Alexander Seifalian is Professor of Nanotechnology and Regenerative Medicine at UCL Centre for Nanotechnology and Regenerative Medicine within the Division of Surgery and Interventional Science at University College London, UK. His research focus is on the development of human organs using nano composite materials and stem cells as well as treatment of cancer using nanoparticles. With nanoparticles requiring rapid and repeatable measurement, Professor Seifalian selected Malvern's NanoSight Nanoparticle Tracking Analysis (NTA) system. Previous to this, he had used techniques including scanning electron microscopy (SEM) and atomic force microscopy (AFM) but found that NTA made measuring size easier and more accurate.
Professor Seifalian's paper, "Fumed Silica Nanoparticle Mediated Biomimicry for Optimal Cell-Material Interactions for Artificial Organ Development" published in the Journal of Macromolecular Biosciences (WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim), was the 1000th peer-reviewed item to be published where results from NTA are cited. In the paper, a fumed silica nanoparticle mediated procedure of scaffold functionalization is described which can be potentially adapted with multiple bioactive molecules to induce cellular biomimicry in the development of human organs. The proposed nanocomposite materials are already in patient use for implants including the world's first synthetic trachea, tear ducts and coronary and vascular bypass grafts.
Nanoparticle Tracking Analysis detects and visualizes populations of nanoparticles in liquids down to 10 nm, dependent on material, and measures the size of each particle from direct observations of diffusion. Additionally, NTA measures concentration while a fluorescence mode differentiates suitably-labelled particles within complex background suspensions.
This real-time data gives insight into the kinetics of protein aggregation and other time-dependent phenomena in a qualitative and quantitative manner. NTA has a growing role in biodiagnostics, being proven in detection and speciation of extracellular vesicles.
NanoSight NTA systems are part of Malvern's extensive portfolio of solutions for the characterization of nanomaterials. To find out about particle characterization using Malvern's unique nanoparticle tracking analysis solutions, visit www.malvern.com/nanoparticle-tracking-analysis.
Malvern, Malvern Instruments and NanoSight are registered trademarks of Malvern Instruments Ltd
About Malvern Instruments
Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.
Our products reflect Malvern’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.
Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.
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