Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticles cause cancer cells to self-destruct

Abstract:
Using magnetically controlled nanoparticles to force tumour cells to ‘self-destruct' sounds like science fiction, but could be a future part of cancer treatment, according to research from Lund University in Sweden.

Nanoparticles cause cancer cells to self-destruct

Lund, Sweden | Posted on April 3rd, 2014

"The clever thing about the technique is that we can target selected cells without harming surrounding tissue. There are many ways to kill cells, but this method is contained and remote-controlled", said Professor Erik Renström.

The point of the new technique is that it is much more targeted than trying to kill cancer cells with techniques such as chemotherapy. "Chemotherapy can also affect healthy cells in the body, and it therefore has serious side-effects. Radiotherapy can also affect healthy tissue around the tumour.

"Our technique, on the other hand, is able to attack only the tumour cells", said Enming Zhang, one of the first authors of the study. In brief, the technique involves getting the nanoparticles into a tumour cell, where they bind to lysosomes, the units in the cell that perform 'cleaning patrols'. The lysosomes have the ability to break down foreign substances that have entered a cell. They can also break down the entire cell through a process known as 'controlled cell death', a type of destruction where damaged cells dissolve themselves.

The researchers have used nanoparticles of iron oxide that have been treated with a special form of magnetism. Once the particles are inside the cancer cells, the cells are exposed to a magnetic field, and the nanoparticles begin to rotate in a way that causes the lysosomes to start destroying the cells.

The research group at Lund University is not the first to try and treat cancer using supermagnetic nanoparticles. However, previous attempts have focused on using the magnetic field to create heat that kills the cancer cells. The problem with this is that the heat can cause inflammation that risks harming surrounding, healthy tissue. The new method, on the other hand, in which the rotation of the magnetic nanoparticles can be controlled, only affects the tumour cells that the nanoparticles have entered.

The new technique is primarily intended for cancer treatment, but according to Erik Renström and his colleague Enming Zhang there may be other areas of application. One example is autoimmune diseases such as type 1 diabetes, in which the immune system attacks the body's own insulin production.

The 'superparamagnetic nanoparticles' have attracted a lot of interest from academia and industry in recent years. They are being tested in research on new diagnostic laboratory tests, new methods of viewing phenomena in living tissue, and new drugs.

The researchers at Lund University have a patent pending for their technique with the rotating nanoparticles. However, a lot of work remains before it can be transferred from the laboratory to clinical trials on patients.

###

The study is a collaboration between physicists, chemists, engineers and doctors from Sweden, Germany and the USA. It has been published in the American journal ACS Nano.

####

For more information, please click here

Contacts:
Professor Erik Renström, Lund University
+46 40 39 11 57


Dr Enming Zhang, researcher at Lund University
+46 40 39 11 64

Copyright © Lund University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article:

Related News Press

News and information

High-speed FM-AFM and simulation reveal atomistic dissolution processes of calcite in water July 28th, 2017

Atomic movies may help explain why perovskite solar cells are more efficient: SLAC's ultrafast 'electron camera' captures surprising atomic motions in these next-generation materials July 28th, 2017

Triple-layer catalyst does double duty: Rice, University of Houston produce robust catalyst to split water into hydrogen, oxygen July 28th, 2017

Arrowhead Pharmaceuticals to Webcast Fiscal 2017 Third Quarter Results July 27th, 2017

Videos/Movies

Nanotech Advances Future Mobile Devices and Wearable Technology July 5th, 2017

ANU invention may help to protect astronauts from radiation in space July 3rd, 2017

Tiny bubbles provide tremendous propulsion in new microparticles research-Ben-Gurion U. June 21st, 2017

Graphene and quantum dots put in motion a CMOS-integrated camera that can see the invisible May 29th, 2017

Nanomedicine

Arrowhead Pharmaceuticals to Webcast Fiscal 2017 Third Quarter Results July 27th, 2017

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Discoveries

High-speed FM-AFM and simulation reveal atomistic dissolution processes of calcite in water July 28th, 2017

Atomic movies may help explain why perovskite solar cells are more efficient: SLAC's ultrafast 'electron camera' captures surprising atomic motions in these next-generation materials July 28th, 2017

Triple-layer catalyst does double duty: Rice, University of Houston produce robust catalyst to split water into hydrogen, oxygen July 28th, 2017

First Capacitive Transducer with 13nm Gap July 27th, 2017

Announcements

High-speed FM-AFM and simulation reveal atomistic dissolution processes of calcite in water July 28th, 2017

Atomic movies may help explain why perovskite solar cells are more efficient: SLAC's ultrafast 'electron camera' captures surprising atomic motions in these next-generation materials July 28th, 2017

Triple-layer catalyst does double duty: Rice, University of Houston produce robust catalyst to split water into hydrogen, oxygen July 28th, 2017

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

High-speed FM-AFM and simulation reveal atomistic dissolution processes of calcite in water July 28th, 2017

Triple-layer catalyst does double duty: Rice, University of Houston produce robust catalyst to split water into hydrogen, oxygen July 28th, 2017

Ultracold molecules hold promise for quantum computing: New approach yields long-lasting configurations that could provide long-sought “qubit” material July 27th, 2017

Atomic discovery opens door to greener, faster, smaller electronic circuitry: Scientists find way to correct communication pathways in silicon chips, making them perfect July 27th, 2017

Patents/IP/Tech Transfer/Licensing

Argonne National Laboratory’s Continuous ALD Technology Licensed Exclusively to Forge Nano July 7th, 2017

Aculon Expands NanoProof® Product Line for Electronics Waterproofing Technology: With growing market opportunities Aculon Launches NanoProof® 8 with Push Through Connectivity™ and NanoProof® DAB a syringe application May 30th, 2017

NREL’s Advanced Atomic Layer Deposition Enables Lithium-Ion Battery Technology: May 10th, 2017

Forge Nano 2017: 1st Quarter Media Update April 20th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project