Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Good vibrations: Using light-heated water to deliver drugs - Researchers use near-infrared light to warm water-infused polymeric particles

In this schematic representation, a hydrated polymeric nanoparticle is exposed to near-infrared light. The NIR heats pockets of water inside the nanoparticle, causing the polymer soften and allowing encapsulated molecules to diffuse into the surrounding environment.

Credit: UC San Diego School of Medicine
In this schematic representation, a hydrated polymeric nanoparticle is exposed to near-infrared light. The NIR heats pockets of water inside the nanoparticle, causing the polymer soften and allowing encapsulated molecules to diffuse into the surrounding environment.

Credit: UC San Diego School of Medicine

Abstract:
Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body.

Good vibrations: Using light-heated water to deliver drugs - Researchers use near-infrared light to warm water-infused polymeric particles

San Diego, CA | Posted on April 1st, 2014

This discovery represents a major innovation, said Adah Almutairi, PhD, associate professor and director of the joint UC San Diego-KACST Center of Excellence in Nanomedicine. Up to now, she said, only a handful of strategies using light-triggered release from nanoparticles have been reported.

The mechanism, described in the April 1, 2014 online issue of ACS Nano, employs near-infrared (NIR) light from a low-power laser to heat pockets of water trapped within non-photo-responsive polymeric nanoparticles infused with drugs. The water pockets absorb the light energy as heat, which softens the encapsulating polymer and allows the drug to be released into the surrounding tissue. The process can be repeated multiple times, with precise control of the amount and dispersal of the drug.

"A key advantage of this mechanism is that it should be compatible with almost any polymer, even those that are commercially available," said Mathieu Viger, a post-doctoral fellow in Almutairi's laboratory and co-lead author of the study. "We've observed trapping of water within particles composed of all the biodegradable polymers we've so far tested."

The method, noted Viger, could thus be easily adopted by many biological laboratories.

The combined use of hydrated polymers and near-infrared light appears to resolve a host of technological and health barriers that have hindered previous, similar approaches. Earlier efforts to use NIR-triggered release have not been widely exploited because they required special designer polymers, expensive high-powered lasers and/or the co-encapsulation of inorganic particles whose safety in the body remains questionable.

The new method described by Almutairi and colleagues in the departments of Mechanical and Aerospace Engineering, Neuroscience, and Chemistry and Biochemistry at UC San Diego uses NIR at a vibrational wavelength cued to excite water molecules, which absorb the optical energy and convert it to heat. NIR is capable of penetrating biological tissues to greater depths than visible or ultraviolet light.

Co-lead author Wangzhong Sheng, a graduate student in Department of Mechanical and Aerospace Engineering, explained the selectivity of heating by comparing the trapped water within particles to a glass of water and the surrounding water within the solution or tissue to a bathtub. The smaller amount of water is heated much more rapidly because of the enormous volume difference.

An obvious use of the method, said Almutairi, is light-triggered drug delivery, but with more research, she anticipates the new method could provide a variety of industrial, medical and scientific applications, including "any technological application requiring that chemistry be controlled in time and in space, such as in catalysis or self-repairing materials or light-activated sunscreens or pesticide dosing."

###

Co-authors include Carl-Johan Carling, Jacques Lux and Caroline de Gracia Lux, UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences; Kim Dore and Roberto Malinow, UCSD Department of Neurosciences; Ali H. Alhasan, UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences and UCSD Center of Excellence in Nanomedicine; and Madeleine Grossman, UCSD Department of Chemistry and Biochemistry.

Funding for this research came, in part, from a National Institutes of Health New Innovator Award (1 DP2 OD006499-01) and NIH grant R01AG032132. This research is in partnership with the King Abdulaziz City of Science and Technology.

####

For more information, please click here

Contacts:
Scott LaFee

619-543-6163

Copyright © University of California - San Diego

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A new, tunable device for spintronics: An international team of scientists including physicist Jairo Sinova from the University of Mainz realises a tunable spin-charge converter made of GaAs August 29th, 2014

Nanoscale assembly line August 29th, 2014

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

Chemistry

Production of Toxic Ion Nanosorbents with High Sorption Capacity in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

Could hemp nanosheets topple graphene for making the ideal supercapacitor? August 12th, 2014

Iranians Find Novel Method for Processing Highly Pure Ceramic Nanoparticles August 12th, 2014

Govt.-Legislation/Regulation/Funding/Policy

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

Leading European communications companies and research organizations have launched an EU project developing the future 5th Generation cellular mobile networks August 28th, 2014

New technique uses fraction of measurements to efficiently find quantum wave functions August 28th, 2014

Nanomedicine

Nanoscale assembly line August 29th, 2014

Copper shines as flexible conductor August 29th, 2014

Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices August 28th, 2014

PetLife Comments on CNN Story on Scorpion Venom Health Benefits August 27th, 2014

Discoveries

A new, tunable device for spintronics: An international team of scientists including physicist Jairo Sinova from the University of Mainz realises a tunable spin-charge converter made of GaAs August 29th, 2014

Nanoscale assembly line August 29th, 2014

Copper shines as flexible conductor August 29th, 2014

Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices August 28th, 2014

Announcements

A new, tunable device for spintronics: An international team of scientists including physicist Jairo Sinova from the University of Mainz realises a tunable spin-charge converter made of GaAs August 29th, 2014

Nanoscale assembly line August 29th, 2014

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

A new, tunable device for spintronics: An international team of scientists including physicist Jairo Sinova from the University of Mainz realises a tunable spin-charge converter made of GaAs August 29th, 2014

Nanoscale assembly line August 29th, 2014

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

Copper shines as flexible conductor August 29th, 2014

Food/Agriculture/Supplements

Iran Unveils 5 Home-Made Knowledge-Based Products August 25th, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

AQUANOVA receives Technology Leadership Award 2014 FROST & SULLIVAN honors NovaSOL® Technology again August 12th, 2014

Personal Care

Sunblock poses potential hazard to sea life August 20th, 2014

AQUANOVA receives Technology Leadership Award 2014 FROST & SULLIVAN honors NovaSOL® Technology again August 12th, 2014

Nanotechnology used in sunscreens: a Mexican achievement May 14th, 2014

Production of Nanocapsule from Sea-Buckthorn Extract in Iran May 3rd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE