Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Trinity College Dublin uses Nanoparticle Tracking Analysis to develop solutions for diagnosis, drug delivery and treatment of cancer

Adriele Prina-Mello, Kieran Staunton and Ciaran Maguire (members of the Nanomedicine group, Trinity College Dublin) with NanoSight's NS500 system.
Adriele Prina-Mello, Kieran Staunton and Ciaran Maguire (members of the Nanomedicine group, Trinity College Dublin) with NanoSight's NS500 system.

Abstract:
NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being applied in the development of future diagnostic and theranostic solutions for early diagnosis, drug delivery and treatment of cancer at the School of Medicine and CRANN, Trinity College Dublin, Ireland.

Trinity College Dublin uses Nanoparticle Tracking Analysis to develop solutions for diagnosis, drug delivery and treatment of cancer

Salisbury, UK | Posted on April 9th, 2013

The School of Medicine (Institute of Molecular Medicine) and CRANN (the Centre for Research on Adaptive Nanostructures and Nanodevices) are based at Trinity College Dublin (TCD) where researchers work in developing new knowledge of nanoscale materials, with a particular focus on new device and sensor technologies, biotechnology and medical technology sectors, with a growing interest in multifunctional materials.

Dr Adriele Prina-Mello is a Research Fellow at CRANN and a part-time lecturer at the School of Medicine, Trinity College Dublin. His research focuses on functional biomaterials, diagnostic devices, and multifunctional nanomaterials for theranostic solutions in the treatment of cancer. Fundamental in this work is the understanding of particle size, size distribution and of hydrodynamic response of nanoparticles dependent on their degree of aggregation. Additionally, being able to measure zeta potential and track particle behavior in viscous or physiologically relevant media, informs the increasing characterization demands of the nanomedicine community. Here pressure is on tools providers to offer the most comprehensive and low volume testing of sometimes very "expensive" samples.

Dr Prina-Mello describes the Nanomedicine team goals: "Our main motivation for such levels of characterization is determined by the potential use, applicability, and safety aspect linked to nanosize materials. This allows for further modification of the particle surface coating/moieties in order to get closer to the suitable candidate for diagnostic, monitoring and therapeutic application for nanomedicine and or biomedical research and also clinical translation. Furthermore, we also need characterization information as basic preliminary understanding, in order to address wider experimental screening based on pharmaceutical standards, necessary to identify potential nanoparticle as lead carrier candidates for drug delivery of therapeutics".

Continuing, he notes the benefits of using NanoSight's NTA instrumentation in complement to other characterization techniques: "NanoSight allows for the identification of heterogeneity in particle size, poly-dispersity and counting with simultaneous zeta potential measurement. Furthermore, the use of small sample volumes compared to other techniques allows for cost effective, daily and routine characterization."

To find out about the company and to learn more about particle characterization using NanoSight's unique nanoparticle tracking analysis solutions, visit www.nanosight.com and register to receive the next issue of NanoTrail, the company's electronic newsletter.

####

About NanoSight
NanoSight delivers the world's most versatile and proven multi-parameter nanoparticle analysis in a single instrument.

NanoSight's "Nanoparticle Tracking Analysis" (NTA) detects and visualizes populations of nanoparticles in liquids down to 10 nm, dependent on material, and measures the size of each particle from direct observations of diffusion. Additionally, NanoSight measures concentration and a fluorescence mode differentiates suitably-labelled particles within complex background suspensions. Zeta potential measurements are similarly particle-specific. It is this particle-by-particle methodology that takes NTA beyond traditional light scattering and other ensemble techniques in providing high-resolution particle size distributions and validates data with information-rich video files of the particles moving under Brownian motion.

This simultaneous multiparameter characterization matches the demands of complex biological systems, hence its wide application in development of drug delivery systems, of viral vaccines, and in nanotoxicology. This real-time data gives insight into the kinetics of protein aggregation and other time-dependent phenomena in a qualitative and quantitative manner. NanoSight has a growing role in biodiagnostics, being proven in detection and speciation of nanovesicles (exosomes) and microvesicles.

NanoSight has installed more than 500 systems worldwide with users including BASF, GlaxoSmithKline, Merck, Novartis, Pfizer, Proctor and Gamble, Roche and Unilever together with the most eminent universities and research institutes. NanoSight's technology is validated by 600+ third party papers citing NanoSight results. NanoSight's leadership position in nanoparticle characterization is consolidated further with publication of an ASTM International standard, ASTM E2834, which describes the NTA methodology for detection and analysis of nanoparticles.

For more information, please click here

Contacts:
NanoSight Limited
Minton Park
London Road
Amesbury SP4 7RT UK
T +44(0)1980 676060
F +44(0)1980 624703
www.nanosight.com


Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA UK
T +44(0)1799 521881
M +44(0)7843 012997
http://www.talking-science.com/

Copyright © NanoSight

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iranian Experts Clean Uranium-Contaminated Water by Nano-Particles November 23rd, 2014

Novel Method Found for Connection of Metallic Alloys to Polymers November 23rd, 2014

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

Nanomedicine

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

Announcements

Iranian Experts Clean Uranium-Contaminated Water by Nano-Particles November 23rd, 2014

Novel Method Found for Connection of Metallic Alloys to Polymers November 23rd, 2014

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

Tools

Iranian Experts Clean Uranium-Contaminated Water by Nano-Particles November 23rd, 2014

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

Nanometrics Announces Upcoming Investor Events November 19th, 2014

Two sensors in one: Nanoparticles that enable both MRI and fluorescent imaging could monitor cancer, other diseases November 18th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE