Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Biofactory introduces kits for assessment of protein-DNA interactions, targeting researchers and industry

Abstract:
Based on a unique technology developed by A*STAR Singapore, these inventive and easy-to-use kits are versatile, effective and quick in the screening for modulators of protein-DNA interactions, as well as quality control (QC) analysis of transcription factor production.

Biofactory introduces kits for assessment of protein-DNA interactions, targeting researchers and industry

Dusseldorf, Germany | Posted on November 14th, 2012

The Biofactory, a leading innovator in incubating biomedical and life sciences related technologies, introduced today its ColoQuik™ line of label-free kits for the rapid colorimetric detection of protein-DNA interactions in biomedical research labs and the pharmaceutical industry. These kits are based on technology licensed from the Institute of Materials Research and Engineering (IMRE), a research institute of the Agency for Science, Technology and Research (A*STAR), Singapore's lead government agency for fostering world-class scientific research. The Biofactory has three kits in its pipeline, each customized for the assessment of a well-known transcription factor in cancer: ERα, ERβ, and p53.

The ColoQuik™ kits will be particularly suited for pharmaceutical companies or academic researchers who require tools for the analysis of protein-DNA interactions at a higher level of throughput. ColoQuik™ kits will find strong utility in primary screens for drugs that can modulate protein-DNA interactions, or in QC analyses of purified DNA-binding proteins based on their DNA-binding capacities.

Conventional techniques for the analysis of protein-DNA interactions tend to pose numerous restrictions and drawbacks upon their users in terms of assay time, expense and throughput. Some methods can involve extensive protocol optimization and materials preparation, with tedious procedures lasting as long as 2 days. Others necessitate tagging of the DNA with radioactive isotopes prior to running the test, which can result in safety and environmental issues. Label-free assays for academia or industry have typically involved hardware and software costs, which limit their utility for primary drug screening.

In comparison, users will find ColoQuik™ assays much easier to use. These tests require only a half-hour to complete on average, and allow for instant visual detection of reagent colour changes based on the quality and affinity of binding between a protein and a specified DNA sequence. The test does not require radioactive or fluorescent labeling of DNA which leads to significant time and cost savings on preparatory work. ColoQuik™ tests require only standard equipment such as microplate absorbance readers for semi-quantitative readouts. As such, these kits are amenable to high-throughput drug discovery applications and batch functional analysis of transcription factor production.

The key technology in the kits is the custom-made, nanometer-sized metal particles created at A*STAR's IMRE. The particles act as probes which give off different colours depending on the specific protein-DNA combinations that are formed in the nanoparticle solution. "These kits offer the easiest and fastest ways to date for scientists to analyse a particular DNA binding protein for its impact on the gene transcription mechanism of specific diseases," said Dr Su Xiaodi, the IMRE Senior Scientist who led the nanoparticle work.

The Biofactory has received beneficial technology assessments from leading scientists who have utilized the technology for their specific experiments. The Biofactory is in the process of manufacturing and marketing the kits to research institutions and pharmaceutical laboratories both in Singapore and around the world.

"The licensing of our materials technology for use in protein-DNA analysis is testament to the value of our research to industry. This development is also a prime example of cross-disciplinary research in action," said Prof Andy Hor, IMRE's Executive Director. "We look forward to seeing this revolutionary new technique being developed further to aid in advancing global healthcare."

"The Biofactory is honoured to be part of the commercialization process. With our expertise in product and business development, we will continue to guide other Singapore-based biomedical innovations towards market success," said Theodore Tan, Managing Director of The Biofactory.

The ColoQuik™ kits will be introduced at this year's MEDICA exhibition in Dusseldorf, Germany. For more product information or licensing enquiries, interested parties may visit thebiofactory.com/coloquik.

####

About The Biofactory Pte Ltd
The Biofactory is a biomedical incubator that catalyses the commercialisation of innovative technologies. With qualified professionals in a wide number of areas, the Biofactory has the technical expertise and experience to bring technologies to market at an accelerated pace. www.thebiofactory.com

About A*STAR’s Institute of Materials Research and Engineering (IMRE)

The Institute of Materials Research and Engineering (IMRE) is a research institute of the Agency for Science, Technology and Research (A*STAR). The Institute has capabilities in materials analysis & characterization, design & growth, patterning & fabrication, as well as synthesis & integration. We house a range of state-of-the-art equipment for materials research including development, processing and characterization. IMRE conducts a wide range of research, which includes novel materials for sensors & transducers, consumer care, organic solar cells, photovoltaics, printed electronics, catalysis, bio-mimetics, microfluidics, quantum dots, heterostructures, sustainable materials and atom technology, among others. We collaborate actively with other research institutes, universities, public bodies, and a wide spectrum of industrial companies, both globally and locally. For more information about IMRE, please visit www.imre.a-star.edu.sg

About the Agency for Science, Technology and Research (A*STAR)

The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that fosters world-class scientific research and talent to drive economic growth and transform Singapore into a vibrant knowledge-based and innovation driven economy. In line with its mission-oriented mandate, A*STAR spearheads research and development in fields that are essential to growing Singapore’s manufacturing sector and catalysing new growth industries. A*STAR supports these economic clusters by providing intellectual, human and industrial capital to its partners in industry. A*STAR oversees 20 biomedical sciences and physical sciences and engineering research entities, located in the Biopolis and Fusionopolis as well as their vicinity. These two R&D hubs house a bustling and diverse community of local and international research scientists and engineers from A*STAR’s research entities as well as a growing number of corporate laboratories. Please visit www.a-star.edu.sgfor more information.

For more information, please click here

Contacts:
Theodore Tan
Phone: (65) 9-638-4201


Name: Eugene Low
Phone: (65) 9-230-9235

Copyright © The Biofactory Pte Ltd

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

UC research partnership explores how to best harness solar power March 2nd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

New Hopes for Treatment of Intestine Cancer by Edible Nanodrug March 2nd, 2015

Nanomedicine

New Hopes for Treatment of Intestine Cancer by Edible Nanodrug March 2nd, 2015

Graphene Shows Promise In Eradication Of Stem Cancer Cells March 1st, 2015

Novel Method to Determine Optical Purity of Drug Components March 1st, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Announcements

UC research partnership explores how to best harness solar power March 2nd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

New Hopes for Treatment of Intestine Cancer by Edible Nanodrug March 2nd, 2015

Tools

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

Mass spectrometers with optimised hydrogen pumping March 1st, 2015

Hiden CATLAB Microreactor System at ARABLAB 2015 | Visit us on Booth 1011 February 26th, 2015

Renishaw and Bruker team up for a workshop on TERS and co-localised AFM Raman February 26th, 2015

Patents/IP/Tech Transfer/Licensing

onic Present breakthrough in CMOS-based Transceivers for mm-Wave Radar Systems March 1st, 2015

New Paper-like Material Could Boost Electric Vehicle Batteries: Researchers create silicon nanofibers 100 times thinner than human hair for potential applications in batteries for electric cars and personal electronics February 20th, 2015

Nanotech Discoveries Move from Lab to Marketplace with Lintec Deal: Licensing Partnership Brings Together University Technology, New Richardson-Based Facility Directed by Alumni February 9th, 2015

Graphenea granted patent on graphene transfer February 9th, 2015

Nanobiotechnology

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Bacteria network for food: Bacteria connect to each other and exchange nutrients February 23rd, 2015

Building tailor-made DNA nanotubes step by step: New, block-by-block assembly method could pave way for applications in opto-electronics, drug delivery February 23rd, 2015

Better batteries inspired by lowly snail shells: Biological molecules can latch onto nanoscale components and lock them into position to make high performing Li-ion battery electrodes, according to new research presented at the 59th annual meeting of the Biophysical Society February 12th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE