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Cell adhesion plays an important functional role in most human cell types and is known to contribute to many tissue maintenance processes, including cell migration, wound healing and cellular differentiation. To study the impact of cell adhesion on these and other cellular functions, an even more fundamental cell adhesion issue must first be addressed: those cells being studied must be affixed to a suitable culture substrate. Thus, characterization of a cell population's ability to adhere to various types of cell adhesive molecules is a primary component of many cell function experiments. Also, the success of a cell culture experiment often depends on the ability to identify a suitable cell adhesive molecule(s) in order to study downstream cellular functions.
Dip Pen Nanolithography (DPN) is capable of printing sub-cellular arrays of multiple cell adhesive molecules, most notably extracellular matrix (ECM) proteins, on glass slides. The multiplexed arrays are ideal for resolving the binding efficiencies of various cell types, and resultant binding efficiency data can in turn help identify the optimal ECM protein and array geometry for each cell type being studied. This DPN technique has been used to screen a specific cell type's adhesion propensities for multiple ECM proteins on a single arrayed slide.
More information is available at: nanoink.net/appnote-screening-cell-adhesion.html
NanoInk, Inc. is an emerging growth technology company specializing in nanometer-scale manufacturing and applications development for the life sciences, engineering, pharmaceutical, and education industries. Using Dip Pen Nanolithography® (DPN®), a patented and proprietary nanofabrication technology, scientists are enabled to rapidly and easily create micro-and nanoscale structures from a variety of materials on a range of substrates. This low cost, easy to use and scalable technique brings sophisticated nanofabrication to the laboratory desktop. Headquartered in the Illinois Science + Technology Park, north of Chicago, NanoInk currently has several divisions including the NanoFabrication Systems Division, the Nano BioDiscovery Division, the NanoProfessor™ Division and the NanoGuardian™ Division. For more information on products and services offered by NanoInk, Inc., visit www.nanoink.net.
NanoInk, the NanoInk logo, Dip Pen Nanolithography, DPN, and NanoProfessor are registered trademarks of NanoInk, Inc.
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