Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials

Dynamic transition in a fibrous biomaterial composed of tunable fractions of structural (red) and water-soluble, sacrificial (green) electrospun polymeric nanofibers. The image was captured as fluid entered from right to left, dissolving sacrificial fibers and creating a more open fibrous network.
Credit: Brendon M. Baker, PhD; Perelman School of Medicine, University of Pennsylvania.
Dynamic transition in a fibrous biomaterial composed of tunable fractions of structural (red) and water-soluble, sacrificial (green) electrospun polymeric nanofibers. The image was captured as fluid entered from right to left, dissolving sacrificial fibers and creating a more open fibrous network.

Credit: Brendon M. Baker, PhD; Perelman School of Medicine, University of Pennsylvania.

Abstract:
Bioengineered replacements for tendons, ligaments, the meniscus of the knee, and other tissues require re-creation of the exquisite architecture of these tissues in three dimensions. These fibrous, collagen-based tissues located throughout the body have an ordered structure that gives them their robust ability to bear extreme mechanical loading.

Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials

Philadelphia, PA | Posted on August 7th, 2012

Many labs have been designing treatments for ACL and meniscus tears of the knee, rotator cuff injuries, and Achilles tendon ruptures for patients ranging from the weekend warrior to the elite Olympian. One popular approach has involved the use of scaffolds made from nano-sized fibers, which can guide tissue to grow in an organized way. Unfortunately, the fibers' widespread application in orthopaedics has been slowed because cells do not readily colonize the scaffolds if fibers are too tightly packed.

Robert L. Mauck, PhD, professor of Orthopaedic Surgery and Bioengineering, and Brendon M. Baker, PhD, previously a graduate student in the Mauck lab at the Perelman School of Medicine, University of Pennsylvania, have developed and validated a new technology in which composite nanofibrous scaffolds provide a loose enough structure for cells to colonize without impediment, but still can instruct cells how to lay down new tissue. Their findings appear online this week in the Proceedings of the National Academy of Sciences.

"These are tiny fibers with a huge potential that can be unlocked by including a temporary, space-holding element," says Mauck. The fibers are on the order of nanometers in diameter. A nanometer is a billionth of a meter.

Using a method that has been around since the 1930s called electrospinning, the team made composites containing two distinct fiber types: a slow-degrading polymer and a water-soluble polymer that can be selectively removed to increase or decrease the spacing between fibers. The fibers are made by electrically charging solutions of dissolved polymers, causing the solution to erupt as a fine spray of fibers which fall like snow onto a rotating drum and collect as a stretchable fabric. This textile can then be shaped for medical applications and cells can be added, or it can be implanted directly -- as a patch of sorts -- into damaged tissue for neighboring cells to colonize.

Increasing the proportion of the dissolving fibers enhanced the ability of host cells to colonize the nanofiber mesh and eventually migrate to achieve a uniform distribution and form a truly three- dimensional tissue. Despite the removal of more than 50 percent of the initial fibers, the remaining scaffold was a sufficient architecture to align cells and direct the formation of a highly organized extracellular matrix by collagen-producing cells. This, in turn, led to a biologic material with tensile properties nearly matching human meniscus tissue, in lab tests of tissue mechanics.

"This approach transforms what was once an interesting biomaterials phenomenon -- cells on the surface of nanofibrous mats -- into a method by which functional, three-dimensional tissues can be formed," says Mauck.

It is a marked step forward in the engineering of load-bearing fibrous tissues, and will eventually find widespread applications in regenerative medicine, say the authors.

Mauck and his team are currently testing these novel materials in a large animal model of meniscus repair and for other orthopaedic applications.

Co-authors are Roshan P. Shah, Amy M. Silverstein, and Jason A. Burdick, all from Penn, and John L. Esterhai, from the Philadelphia VA Medical Center.

This work was supported by National Institutes of Health Grant R01 AR056624 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and a Department of Veterans Affairs Grant I01 RX000174.

####

About University of Pennsylvania School of Medicine
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine is currently ranked #2 in U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $479.3 million awarded in the 2011 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital - the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2011, Penn Medicine provided $854 million to benefit our community.

For more information, please click here

Contacts:
Karen Kreeger

215-349-5658

Copyright © University of Pennsylvania School of Medicine

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Govt.-Legislation/Regulation/Funding/Policy

New technology using silver may hold key to electronics advances July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Influential Interfaces Lead to Advances in Organic Spintronics July 1st, 2015

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Nanomedicine

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Discoveries

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Materials/Metamaterials

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

New technology using silver may hold key to electronics advances July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Proposed TSCA Nanomaterial Rule ‘Premature’, Says Former EPA Toxicologist July 1st, 2015

Announcements

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Military

Graphene flexes its electronic muscles: Rice-led researchers calculate electrical properties of carbon cones, other shapes June 30th, 2015

The peaks and valleys of silicon: Team of USC Viterbi School of Engineering Researchers introduce new layered semiconducting materials as silicon alternative June 27th, 2015

Opening a new route to photonics Berkeley lab researchers find way to control light in densely packed nanowaveguides June 27th, 2015

World’s 1st Full-Color, Flexible, Skin-Like Display Developed at UCF June 24th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project