Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanostructured Sensors Power Novel Cancer Detection System

Abstract:
Using a sensor made of densely packed carbon nanotubes coated with gold nanoparticles, a researcher team headed by James Rusling of the University of Connecticut has developed a low-cost microfluidic device for detecting oral cancer. According to the researchers, the device is readily adaptable to detecting other cancers.

Nanostructured Sensors Power Novel Cancer Detection System

Bethesda, MD | Posted on July 2nd, 2012

Tests on samples obtained from 78 oral cancer patients and 49 control subjects showed that the device has a clinical sensitivity of 89% and specificity of 98% for detecting oral cancer. Dr. Rusling and his collaborators published their results in the journal Analytical Chemistry. While other groups have also developed analytical methods that produce similar promise for detecting blood-borne biomarkers of oral cancer, these methods are based on time-consuming and expensive technologies.

The microfluidic device that Dr. Rusling's team developed simultaneously detects extraordinarily low levels of four proteins that together provide a diagnostic signature for oral cancer. Magnetic beads, each coated with 120,000 antibody molecules, are used to capture even trace levels of specific biomarker proteins and remove them from a blood sample. The magnetic particles are then injected into the microfluidic device, which flows the beads over the sensor elements. Each sensor's electrical output corresponds to blood levels of a specific protein.

According to the investigators, the entire assay takes 50 minutes to perform. Each disposable carbon nanotube sensor chip costs about $9. The readout device uses available electronic components and pumps that together cost under $26,000, which "makes this approach accessible to virtually any biomedical laboratory at a small cost."

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with todayís explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Ultrasensitive detection of cancer biomarkers in the clinic using a nanostructured microfluidic assay."

Related News Press

News and information

The School of Materials at the University of Manchester utilise Debenís mechanical stages to characterise structure and behaviour at the micro- and nano- scale July 25th, 2017

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Ultrathin device harvests electricity from human motion July 23rd, 2017

The July 23 close fly-by of asteroid 2017 BS5 is explored in a Q&A with Dr. John S. Lewis, chief scientist at Deep Space Industries July 23rd, 2017

Microfluidics/Nanofluidics

Using light to propel water : With new method, MIT engineers can control and separate fluids on a surface using only visible light April 25th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Particle Works creates range of high performance quantum dots February 23rd, 2017

DNA 'barcoding' allows rapid testing of nanoparticles for therapeutic delivery February 7th, 2017

Govt.-Legislation/Regulation/Funding/Policy

Ultrathin device harvests electricity from human motion July 23rd, 2017

The first light atomic nucleus with a second face July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Here's a tip: Indented cement shows unique properties: Rice University models reveal nanoindentation can benefit crystals in concrete July 20th, 2017

Nanotubes/Buckyballs/Fullerenes/Nanorods

Killing cancer in the heat of the moment: A new method efficiently transfers genes into cells, then activates them with light. This could lead to gene therapies for cancers July 9th, 2017

Tests show no nanotubes released during utilisation of nanoaugmented materials June 9th, 2017

Ag/ZnO-Nanorods Schottky diodes based UV-PDs are fabricated and tested May 26th, 2017

Fed grant backs nanofiber development: Rice University joins Department of Energy 'Next Generation Machines' initiative May 10th, 2017

Nanomedicine

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Probiotics: Novel biosynthetic tool to develop metallic nanoparticles: This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017 July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Sensors

Giant enhancement of electromagnetic waves revealed within small dielectric particles: Scientists have done for the first time direct measurements of giant electromagnetic fields July 8th, 2017

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Letiís Autonomous-Vehicle System Embedded in Infineonís AURIX Platform: Letiís Low-Power, Multi-Sensor System that Transforms Distance Data into Clear Information About the Driving Environment Will Be Demonstrated at ITS Meeting in Strasbourg, June 19-22 June 20th, 2017

New diode features optically controlled capacitance: Israeli researchers have developed a new optically tunable capacitor with embedded metal nanoparticles, creating a metal-insulator-semiconductor diode that is tunable by illumination. June 8th, 2017

Discoveries

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Pulses of electrons manipulate nanomagnets and store information: Scientists use electron pulses to create and manipulate nanoscale magnetic excitations that can store data July 21st, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Announcements

The School of Materials at the University of Manchester utilise Debenís mechanical stages to characterise structure and behaviour at the micro- and nano- scale July 25th, 2017

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Ultrathin device harvests electricity from human motion July 23rd, 2017

The July 23 close fly-by of asteroid 2017 BS5 is explored in a Q&A with Dr. John S. Lewis, chief scientist at Deep Space Industries July 23rd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project