Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanostructured Sensors Power Novel Cancer Detection System

Abstract:
Using a sensor made of densely packed carbon nanotubes coated with gold nanoparticles, a researcher team headed by James Rusling of the University of Connecticut has developed a low-cost microfluidic device for detecting oral cancer. According to the researchers, the device is readily adaptable to detecting other cancers.

Nanostructured Sensors Power Novel Cancer Detection System

Bethesda, MD | Posted on July 2nd, 2012

Tests on samples obtained from 78 oral cancer patients and 49 control subjects showed that the device has a clinical sensitivity of 89% and specificity of 98% for detecting oral cancer. Dr. Rusling and his collaborators published their results in the journal Analytical Chemistry. While other groups have also developed analytical methods that produce similar promise for detecting blood-borne biomarkers of oral cancer, these methods are based on time-consuming and expensive technologies.

The microfluidic device that Dr. Rusling's team developed simultaneously detects extraordinarily low levels of four proteins that together provide a diagnostic signature for oral cancer. Magnetic beads, each coated with 120,000 antibody molecules, are used to capture even trace levels of specific biomarker proteins and remove them from a blood sample. The magnetic particles are then injected into the microfluidic device, which flows the beads over the sensor elements. Each sensor's electrical output corresponds to blood levels of a specific protein.

According to the investigators, the entire assay takes 50 minutes to perform. Each disposable carbon nanotube sensor chip costs about $9. The readout device uses available electronic components and pumps that together cost under $26,000, which "makes this approach accessible to virtually any biomedical laboratory at a small cost."

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Ultrasensitive detection of cancer biomarkers in the clinic using a nanostructured microfluidic assay."

Related News Press

News and information

Solar-to-fuel system recycles CO2 to make ethanol and ethylene: Berkeley Lab advance is first demonstration of efficient, light-powered production of fuel via artificial photosynthesis September 19th, 2017

A new approach to ultrafast light pulses: Unusual fluorescent materials could be used for rapid light-based communications systems September 19th, 2017

New quantum phenomena in graphene superlattices September 18th, 2017

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Microfluidics/Nanofluidics

Using light to propel water : With new method, MIT engineers can control and separate fluids on a surface using only visible light April 25th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Particle Works creates range of high performance quantum dots February 23rd, 2017

DNA 'barcoding' allows rapid testing of nanoparticles for therapeutic delivery February 7th, 2017

Govt.-Legislation/Regulation/Funding/Policy

Solar-to-fuel system recycles CO2 to make ethanol and ethylene: Berkeley Lab advance is first demonstration of efficient, light-powered production of fuel via artificial photosynthesis September 19th, 2017

New insights into nanocrystal growth in liquid: Understanding process that creates complex crystals important for energy applications September 14th, 2017

Magnetic cellular 'Legos' for the regenerative medicine of the future September 12th, 2017

First on-chip nanoscale optical quantum memory developed: Smallest-yet optical quantum memory device is a storage medium for optical quantum networks with the potential to be scaled up for commercial use September 11th, 2017

Nanotubes/Buckyballs/Fullerenes/Nanorods

How to draw electricity from the bloodstream: A one-dimensional fluidic nanogenerator with a high power-conversion efficiency September 11th, 2017

Silk could improve sensitivity, flexibility of wearable body sensors August 20th, 2017

Regulation of two-dimensional nanomaterials: New driving force for lithium-ion batteries July 26th, 2017

Killing cancer in the heat of the moment: A new method efficiently transfers genes into cells, then activates them with light. This could lead to gene therapies for cancers July 9th, 2017

Nanomedicine

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Arrowhead Hosts Investor & Analyst R&D Day to Introduce TRiM(TM) Platform and Lead RNAi-based Drug Candidates September 14th, 2017

Graphene based terahertz absorbers: Printable graphene inks enable ultrafast lasers in the terahertz range September 13th, 2017

Applications for the nanomedTAB are open until September 18th, 2017 September 13th, 2017

Sensors

Research shows how DNA molecules cross nanopores: Study could inform biosensors, manufacturing, and more September 5th, 2017

Leti and Partners in PiezoMAT Project Develop New Fingerprint Technology for Highly Reliable Security and ID Applications: Ultra-high Resolution Pressure Sensing Uses Matrices of Vertical Piezoelectric Nanowire To Reconstruct the Smallest Features of Human Fingerprints September 5th, 2017

New results reveal high tunability of 2-D material: Berkeley Lab-led team also provides most precise band gap measurement yet for hotly studied monolayer moly sulfide August 26th, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Discoveries

Solar-to-fuel system recycles CO2 to make ethanol and ethylene: Berkeley Lab advance is first demonstration of efficient, light-powered production of fuel via artificial photosynthesis September 19th, 2017

A new approach to ultrafast light pulses: Unusual fluorescent materials could be used for rapid light-based communications systems September 19th, 2017

New quantum phenomena in graphene superlattices September 18th, 2017

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Announcements

Solar-to-fuel system recycles CO2 to make ethanol and ethylene: Berkeley Lab advance is first demonstration of efficient, light-powered production of fuel via artificial photosynthesis September 19th, 2017

A new approach to ultrafast light pulses: Unusual fluorescent materials could be used for rapid light-based communications systems September 19th, 2017

New quantum phenomena in graphene superlattices September 18th, 2017

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project