Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Tiny 'speed bump' device could sort cancer cells

In an illustration, magnetically labeled circulating tumor cells (shown as yellow spheres) travel with red and white blood cells and platelets over an array of slanted ramps in the device. The ramps act as speed bumps, slowing the tumor cells. As the tumor cells slow, the flow carries them along the length of the ramp, causing lateral displacement. After the tumor cells traverse an array of these ramps, they have sufficiently been displaced and can be continuously isolated from other cells in the sample.

Credit: Martin Rietveld
In an illustration, magnetically labeled circulating tumor cells (shown as yellow spheres) travel with red and white blood cells and platelets over an array of slanted ramps in the device. The ramps act as speed bumps, slowing the tumor cells. As the tumor cells slow, the flow carries them along the length of the ramp, causing lateral displacement. After the tumor cells traverse an array of these ramps, they have sufficiently been displaced and can be continuously isolated from other cells in the sample.

Credit: Martin Rietveld

Abstract:
In life, we sort soiled laundry from clean; ripe fruit from rotten. Two Johns Hopkins engineers say they have found an easy way to use gravity or simple forces to similarly sort microscopic particles and bits of biological matter -- including circulating tumor cells.

Tiny 'speed bump' device could sort cancer cells

Baltimore, MD | Posted on June 12th, 2012

In the May 25 online issue of Physical Review Letters, German Drazer, an assistant professor of chemical and biomolecular engineering, and his doctoral student, Jorge A. Bernate, reported that they have developed a lab-on-chip platform, also known as a microfluidic device, that can sort particles, cells or other tiny matter by physical means such as gravity. By moving a liquid over a series of micron-scale high diagonal ramps -- similar to speed bumps on a road -- the device causes microscopic material to separate into discrete categories, based on weight, size or other factors, the team reported.

The process described in the journal article could be used to produce a medical diagnostic tool, the Whiting School of Engineering researchers say. "The ultimate goal is to develop a simple device that can be used in routine checkups by health care providers," said doctoral student Bernate, who is lead author on the paper. "It could be used to detect the handful of circulating tumor cells that have managed to survive among billions of normal blood cells. This could save millions of lives."

Ideally, these cancer cells in the bloodstream could be detected and targeted for treatment before they've had a chance to metastasize, or spread cancer elsewhere. Detection at early stages of cancer is critical for successful treatment.

How does this sorting process occur? Bernate explained that inside the microfluidic device, particles and cells suspended in liquid flow along a "highway" that has speed-bump-like obstacles positioned diagonally, instead of perpendicular to the path. The speed bumps differ in height, depending on the application.

"As different particles are driven over these diagonal speed bumps, heavier ones have a harder time getting over than the lighter ones," the doctoral student said. When the particles cannot get over the ramp, they begin to change course and travel diagonally along the length of the obstacle. As the process continues, particles end up fanning out in different directions.

"After the particles cross this section of the 'highway,'" Bernate said, "they end up in different 'lanes' and can take different 'exits,' which allows for their continuous separation."

Gravity is not the only way to slow down and sort particles as they attempt to traverse the speed bumps. "Particles with an electrical charge or that are magnetic may also find it hard to go up over the obstacles in the presence of an electric or magnetic field," Bernate said. For example, cancer cells could be "weighted down" with magnetic beads and then sorted in a device with a magnetic field.

The ability to sort and separate things at the micro- and nanoscale is important in many industries, ranging from solar power to bio-security. But Bernate said that a medical application is likely to be the most promising immediate use for the device.

He is slated to complete his doctoral studies this summer, but until then, Bernate will continue to collaborate with researchers in the lab of Konstantinos Konstantopoulos, professor and chair of the Department of Chemical and Biomolecular Engineering, and with colleagues at InterUniversity Microelectronics Center, IMEC, in Belgium. In 2011, Bernate spent 10 weeks at IMEC in a program hosted by Johns Hopkins' Institute for NanoBioTechnology and funded by the National Science Foundation.

His doctoral adviser, Drazer, said, the research described in the new journal article eventually led Jorge down the path at IMEC to develop a device that can easily sort whole blood into its components. A provisional patent has been filed for this device.

The research by Bernate and Drazer was funded in part by the National Science Foundation and the National Institutes of Health.

Illustrations and short video available; contact Mary Spiro or Phil Sneiderman.

####

For more information, please click here

Contacts:
Mary Spiro

410-516-4802

Copyright © Johns Hopkins University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

German Drazer's Web page:

Department of Chemical and Biomolecular Engineering:

Related News Press

News and information

Novel approach to magnetic measurements atom-by-atom October 1st, 2014

Nanoparticles Accumulate Quickly in Wetland Sediment: Aquatic food chains might be harmed by molecules "piggybacking" on carbon nanoparticles October 1st, 2014

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail October 1st, 2014

Videos/Movies

Smallest possible diamonds form ultra-thin nanothreads: Diamond nanothreads are likely to have extraordinary properties, including strength and stiffness greater than that of today's strongest nanotubes and polymers September 22nd, 2014

Next-Gen Luxury RV From Global Caravan Technologies Will Offer MagicView Roof and Windshield Using SPD-SmartGlass Technology From Research Frontiers: Recreational Vehicle Manufacturer Global Caravan Technologies (GCT) Features 28 Square Feet of MagicView™ SPD-SmartGlass September 17th, 2014

Scientists refine formula for nanotube types: Rice University theorists determine factors that give tubes their chiral angles September 17th, 2014

RMIT delivers $30m boost to micro and nano-tech August 26th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Novel approach to magnetic measurements atom-by-atom October 1st, 2014

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

NREL Announces New Center Directors to lead R&D, Analysis Efforts September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

Nanomedicine

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

New Absorber Will Lead to Better Biosensor: Biosensors are more sensitive and able to detect smaller changes in the environment October 1st, 2014

Ad-REIC vaccine: A magic bullet for cancer treatment September 30th, 2014

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Discoveries

Novel approach to magnetic measurements atom-by-atom October 1st, 2014

Nanoparticles Accumulate Quickly in Wetland Sediment: Aquatic food chains might be harmed by molecules "piggybacking" on carbon nanoparticles October 1st, 2014

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail October 1st, 2014

Announcements

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail October 1st, 2014

New Absorber Will Lead to Better Biosensor: Biosensors are more sensitive and able to detect smaller changes in the environment October 1st, 2014

Graphene chips are close to significant commercialization October 1st, 2014

Research partnerships

Novel approach to magnetic measurements atom-by-atom October 1st, 2014

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail October 1st, 2014

Research mimics brain cells to boost memory power September 30th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE