Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanofiber Breakthrough Holds Promise for Medicine and Microprocessors

Abstract:
A new method for creating nanofibers made of proteins, developed by researchers at Polytechnic Institute of New York University (NYU-Poly), promises to greatly improve drug delivery methods for the treatment of cancers, heart disorders and Alzheimer's disease, as well as aid in the regeneration of human tissue, bone and cartilage.

Nanofiber Breakthrough Holds Promise for Medicine and Microprocessors

Brooklyn, NY | Posted on February 29th, 2012

In addition, applied differently, this same development could point the way to even tinier and more powerful microprocessors for future generations of computers and consumer electronics devices.

The details are spelled out in an article titled "Effects of Divalent Metals on Nanoscopic Fiber Formation and Small Molecule Recognition of Helical Proteins," which appears online in Advanced Functional Materials. Author Susheel K. Gunasekar, a doctoral student in NYU-Poly's Department of Chemical and Biological Sciences, was the primary researcher, and is a student of co-author Jin Montclare, assistant professor and head of the department's Protein Engineering and Molecular Design Lab, where the underlying research was primarily conducted. Also involved were co-authors Luona Anjia, a graduate student, and Professor Hiroshi Matsui, both of the Department of Chemistry and Biochemistry at Hunter College (The City University of New York), where secondary research was conducted.

Yet all of this almost never emerged, says Professor Montclare, who explains that it was sheer "serendipity" -- a chance observation made by Gunasekar two years ago -- that inspired the team's research and led to its significant findings.

During an experiment that involved studying certain cylinder-shaped proteins derived from cartilage oligomeric matrix protein (COMP, found predominantly in human cartilage), Gunasekar noticed that in high concentrations, these alpha helical coiled-coil proteins spontaneously came together and self-assembled into nanofibers. It was a surprising outcome, Montclare says, because COMP was not known to form fibers at all. "We were really excited," she recalls. "So we decided to do a series of experiments to see if we could control the fiber formation, and also control its binding to small molecules, which would be housed within the protein's cylinder."

Of special interest were molecules of curcumin, an ingredient in dietary supplements used to combat Alzheimer's disease, cancers and heart disorders.

By adding a set of metal-recognizing amino acids to the coiled-coil protein, the NYU-Poly team succeeded, finding that the nanofibers alter their shapes upon addition of metals such as zinc and nickel to the protein. Moreover, the addition of zinc fortified the nanofibers, enabling them to hold more curcumin, while the addition of nickel transformed the fibers into clumped mats, triggering the release of the drug molecule.

Next, Montclare says, the researchers plan to experiment with creating scaffolds of nanofibers that can be used to induce the regeneration of bone and cartilage (via embedded vitamin D) or human stem cells (via embedded vitamin A).

Later, it may even be possible to apply this organic, protein-based method for creating nanofibers to the world of computers and consumer electronics, Montclare says -- producing nanoscale gold threads for use as circuits in computer chips by first creating the nanofibers and then guiding that metal to them.

Ultimately, Montclare says, the researchers would like the fruits of their discovery -- such therapeutic nanofibers and metallic nanowires -- to be adopted by pharmaceutical companies and microprocessor makers alike.

Funding for this NYU-Poly research was provided by the U.S. Air Force Office of Scientific Research, the U.S. Army Research Office, the U.S. Department of Energy and the National Science Foundation.

####

About Polytechnic Institute of New York University
Polytechnic Institute of New York University (formerly Polytechnic University), an affiliate of New York University, is a comprehensive school of engineering, applied sciences, technology and research, and is rooted in a 158-year tradition of invention, innovation and entrepreneurship: i2e. The institution, founded in 1854, is the nation’s second-oldest private engineering school. In addition to its main campus in New York City at MetroTech Center in downtown Brooklyn, it also offers programs at sites throughout the region and around the globe. Globally, NYU-Poly has programs in Israel, China and is an integral part of NYU's campus in Abu Dhabi.

For more information, please click here

Contacts:
Kathleen Hamilton

718-260-3792

Copyright © Polytechnic Institute of New York University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iran Exports Nanodrugs to Syria November 24th, 2014

Iranian Experts Clean Uranium-Contaminated Water by Nano-Particles November 23rd, 2014

Novel Method Found for Connection of Metallic Alloys to Polymers November 23rd, 2014

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Sustainable Nanotechnologies Project November 20th, 2014

Chip Technology

Nanometrics Announces Upcoming Investor Events November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Researchers create & control spin waves, lifting prospects for enhanced info processing November 17th, 2014

VDMA Electronics Production Equipment: Growth track for 2014 and 2015 confirmed: Business climate survey shows robust industry sector November 14th, 2014

Nanotubes/Buckyballs

Tesla NanoCoatings Increasing Use of SouthWest NanoTechnologies Carbon Nanotubes (CNTs) for its Infrastructure Coatings and Paints: High Quality SMW™ Specialty Multi-wall Carbon Nanotubes Incorporated into Teslan®-brand coatings used by Transportation, Oil and Gas Companies November 19th, 2014

Graphene/nanotube hybrid benefits flexible solar cells: Rice University labs create novel electrode for dye-sensitized cells November 17th, 2014

SouthWest NanoTechnologies to Demonstrate 3D Capacitive Touch Sensor Featuring Transparent, Thermoformed Carbon Nanotube Ink at Printed Electronics USA 2014 (Booth J25) -- “Conductive and Semiconducting Single-Wall Carbon Nanotube Inks” will be Topic of Company Presentation November 10th, 2014

Neural Canals Produced in Iran for Recovery of Sciatica Nerve November 8th, 2014

Discoveries

Iranian Experts Clean Uranium-Contaminated Water by Nano-Particles November 23rd, 2014

Novel Method Found for Connection of Metallic Alloys to Polymers November 23rd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Announcements

Iran Exports Nanodrugs to Syria November 24th, 2014

Iranian Experts Clean Uranium-Contaminated Water by Nano-Particles November 23rd, 2014

Novel Method Found for Connection of Metallic Alloys to Polymers November 23rd, 2014

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

Military

NRL Scientists Discover Novel Metamaterial Properties within Hexagonal Boron Nitride November 20th, 2014

Two sensors in one: Nanoparticles that enable both MRI and fluorescent imaging could monitor cancer, other diseases November 18th, 2014

Researchers create & control spin waves, lifting prospects for enhanced info processing November 17th, 2014

Penn engineers efficiently 'mix' light at the nanoscale November 17th, 2014

Nanobiotechnology

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Implementation of DNA Chains in Designing Nanospin Pieces November 9th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE