Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Rice chemists cram 2 million nanorods into single cancer cell: Breakthrough in loading gold nanorods into cells could lead to new cancer treatment

Rice University's Leonid Vigderman (left) and Eugene Zubarev have found a way to load more than 2 million tiny gold particles called nanorods into a single cancer cell.
CREDIT: Jeff Fitlow/Rice University
Rice University's Leonid Vigderman (left) and Eugene Zubarev have found a way to load more than 2 million tiny gold particles called nanorods into a single cancer cell.

CREDIT: Jeff Fitlow/Rice University

Abstract:
Rice University chemists have found a way to load more than 2 million tiny gold particles called nanorods into a single cancer cell. The breakthrough could speed development of cancer treatments that would use nanorods like tiny heating elements to cook tumors from the inside.

Rice chemists cram 2 million nanorods into single cancer cell: Breakthrough in loading gold nanorods into cells could lead to new cancer treatment

Houston, TX | Posted on November 16th, 2011

The research appears online this week in the chemical journal Angewandte Chemie International Edition.

"The breast cancer cells that we studied were so laden with gold nanorods that their masses increased by an average of about 13 percent," said study leader Eugene Zubarev, associate professor of chemistry at Rice. "Remarkably, the cells continued to function normally, even with all of this gold inside them."

Though the ultimate goal is to kill cancer, Zubarev said the strategy is to deliver nontoxic particles that become deadly only when they are activated by a laser.
The nanorods, which are about the size of a small virus, can harvest and convert otherwise harmless light into heat. But because each nanorod radiates miniscule heat, many are needed to kill a cell.

"Ideally, you'd like to use a low-power laser to minimize the risks to healthy tissue, and the more particles you can load inside the cell, the lower you can set the power level and irradiation time," said Zubarev, an investigator at Rice's BioScience Research Collaborative (BRC).

Unfortunately, scientists who study gold nanorods have found it difficult to load large numbers of particles into living cells. For starters, nanorods are pure gold, which means they won't dissolve in solution unless they are combined with some kind of polymer or surfactant. The most commonly used of these is cetyltrimethylammonium bromide, or CTAB, a soapy chemical often used in hair conditioner.

CTAB is a key ingredient in the production of nanorods, so scientists have often relied upon it to make nanorods soluble in water. CTAB does this job by coating the surface of the nanorods in much the same way that soap envelopes and dissolves droplets of grease in dishwater. CTAB-encased nanorods also have a positive charge on their surfaces, which encourages cells to ingest them. Unfortunately, CTAB is also toxic, which makes it problematic for biomedical applications.

In the new research, Zubarev, Rice graduate student Leonid Vigderman and former graduate student Pramit Manna, now at Applied Materials Inc., describe a method to completely replace CTAB with a closely related molecule called MTAB that has two additional atoms attached at one end.

The additional atoms -- one sulfur and one hydrogen -- allow MTAB to form a permanent chemical bond with gold nanorods. In contrast, CTAB binds more weakly to nanorods and has a tendency to leak into surrounding media from time to time, which is believed to be the underlying cause of CTAB-encased nanorod toxicity.

It took Zubarev, Vigderman and Manna several years to identify the optimal strategy to synthesize MTAB and substitute it for CTAB on the surface of the nanorods. In addition, they developed a purification process that can completely remove all traces of CTAB from a solution of nanorods.

The research was funded by the National Science Foundation.

Rice's BRC is an innovative space where scientists and educators from Rice and other institutions in the Texas Medical Center work together to perform leading research that benefits human medicine and health.

####

About Rice University
Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation's top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is known for its "unconventional wisdom." With 3,708 undergraduates and 2,374 graduate students, Rice's undergraduate student-to-faculty ratio is less than 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice has been ranked No. 1 for best quality of life multiple times by the Princeton Review and No. 4 for "best value" among private universities by Kiplinger's Personal Finance. To read "What they're saying about Rice," go to www.rice.edu/nationalmedia/Rice.pdf.

For more information, please click here

Contacts:
David Ruth
713-348-6327


Jade Boyd
713-348-6778

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The report in Angewandte Chemie is available at:

Related News Press

News and information

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Leti Announces EU Project to Develop Powerful, Inexpensive Sensors with Photonic Integrated Circuits: REDFINCH Members Initially Targeting Applications for Gas Detection and Analysis For Refineries & Petrochemical Industry and Protein Analysis for Dairy Industry September 19th, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

Videos/Movies

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

Peering into private life of atomic clusters -- using the world's tiniest test tubes September 6th, 2018

Govt.-Legislation/Regulation/Funding/Policy

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Could a demon help to create a quantum computer? Physicists implement a version of Maxwell's famous thought experiment for reducing entropy September 5th, 2018

Nanomedicine

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

A Comprehensive Guide: The Future of Nanotechnology September 13th, 2018

Discoveries

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Announcements

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Leti Announces EU Project to Develop Powerful, Inexpensive Sensors with Photonic Integrated Circuits: REDFINCH Members Initially Targeting Applications for Gas Detection and Analysis For Refineries & Petrochemical Industry and Protein Analysis for Dairy Industry September 19th, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project