Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Researchers Link DNA to Nanostructures

Jin-Woo Kim, University of Arkansas
Jin-Woo Kim, University of Arkansas

Abstract:
Assembly of nanostructures using DNA may lead to the production of new materials with a wide range of applications from electronics to tissue engineering. Researchers in the Institute for Nanoscience and Engineering at the University of Arkansas have produced building blocks for such material by controlling the number, placement and orientation of DNA linkers on the surface of colloidal nanoparticles.

Researchers Link DNA to Nanostructures

Fayetteville, AR | Posted on September 20th, 2011

Their work is featured as the "hot paper" in the current issue of Angewandte Chemie International Edition, the weekly scientific journal of the German Chemical Society.

"We have demonstrated a strategy to place DNA linkers' on a nanoparticle at specific angles relative to each other so that we may produce building blocks with well-defined arrangements of DNA in all dimensions," said Jin-Woo Kim, professor of biological engineering. "The specific number and orientation of DNA strands on the nanoparticles allow greater control over the ultimate shape of nanostructures."

DNA linkers are areas on the nanoparticles that functionally allow connection with other nanoparticles. In this case, connection is achieved through a type of DNA hybridization reaction.

The simple and sustainable strategy involves attaching strands of DNA to functionalized nanoparticles one strand after the other rather than all at the same time. The nanoparticle with the first strand serves as the starting material for the second strand. The nanoparticle with these two strands together serves as the starting material for the third, and so on. In addition to facilitating greater control over the shape of the structure, assembling in this sequential manner renders the process more reproducible and scalable, which helps with the assembly of complex, hybrid nanoscale architectures at all scales and in all dimensions.

The building blocks, which the researchers call "nBLOCKs," remained stable under volatile conditions. They exhibited chemical stability and water solubility during ligand replacement reactions. There were no apparent changes in physical and chemical properties when the building blocks were stored at 4 degrees Celsius for at least a month. Such promising stability shows high potential for their practical application. The researchers continue working on further optimizing their physical and chemical stability.

Kim said the building strategy can be generalized for other types of nanoparticles, meaning that construction of other types of building blocks with specific, desired functions may be achieved. The technology has the potential to transform many fields of research, including biology, medicine, chemistry, physics, materials science and engineering.

The research was supported by the National Science Foundation, the University of Arkansas Division of Agriculture and the Arkansas Biosciences Institute.

The work was a multidisciplinary, collaborative effort with Russell Deaton, professor of computer science and computer engineering. Jeong-Hwan Kim, postdoctoral associate at the Bio/Nano Technology Laboratory, also made a significant contribution to the project.

Jin-Woo Kim is a professor in the Dale Bumpers College of Agricultural, Food and Life Sciences and the College of Engineering. He works in the Institute for Nanoscience and Engineering at the University of Arkansas and directs the Bio/Nano Technology Laboratory.

####

For more information, please click here

Contacts:
Jin-Woo Kim
professor
Biological and Agricultural Engineering
479-575-3402


Matt McGowan
science and research
communications officer
University Relations
479-575-4246

Copyright © Newswise

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Information storage with a nanoscale twist: Discovery of a novel rotational force inside magnetic vortices makes it easier to design ultrahigh capacity disk drives March 28th, 2017

ATTOPSEMI Technology Joins FDXcelerator Program to Deliver Advanced Non-Volatile Memory IP to GLOBALFOUNDRIES 22 FDX Technology Platform: Leading-edge I-fuse brings higher reliability, smaller cell size and ease of programmability for consumer, automotive, and IoT applications March 27th, 2017

Leti and HORIBA Scientific to Host Webinar on Ultrafast Characterization Tool: Plasma Profiling Time-of-Flight Mass Spectrometer Tool Cuts Optimization Time In Layer Deposition and Fabrication of Wide Range of Applications March 27th, 2017

Laser activated gold pyramids could deliver drugs, DNA into cells without harm: Microstructures create temporary pores in cells March 27th, 2017

Chemistry

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Researchers develop groundbreaking process for creating ultra-selective separation membranes: Discovery could greatly improve energy-efficiency of separation and purification processes in the chemical and petrochemical industries March 15th, 2017

Optical fingerprint can reveal pollutants in the air: Researchers at Chalmers University of Technology have proposed a new, sophisticated method of detecting molecules with sensors based on ultra-thin nanomaterials March 15th, 2017

Triboelectric Nanogenerators Boost Mass Spectrometry Performance March 1st, 2017

Physics

Breakthrough with a chain of gold atoms: In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport February 20th, 2017

Research reveals novel quantum state in strange insulating materials February 14th, 2017

Sorting machine for atoms:Researchers at the University of Bonn clear a further hurdle on the path to creating quantum computers February 10th, 2017

The shape of melting in two dimensions: University of Michigan team uses Titan to explore fundamental phase transitions February 2nd, 2017

Govt.-Legislation/Regulation/Funding/Policy

A big leap toward tinier lines: Self-assembly technique could lead to long-awaited, simple method for making smaller microchip patterns March 27th, 2017

Laser activated gold pyramids could deliver drugs, DNA into cells without harm: Microstructures create temporary pores in cells March 27th, 2017

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Nanomedicine

Laser activated gold pyramids could deliver drugs, DNA into cells without harm: Microstructures create temporary pores in cells March 27th, 2017

Researchers make flexible glass for tiny medical devices: Glass can bend over and over again on a nanoscale March 27th, 2017

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Discoveries

Information storage with a nanoscale twist: Discovery of a novel rotational force inside magnetic vortices makes it easier to design ultrahigh capacity disk drives March 28th, 2017

A big leap toward tinier lines: Self-assembly technique could lead to long-awaited, simple method for making smaller microchip patterns March 27th, 2017

Laser activated gold pyramids could deliver drugs, DNA into cells without harm: Microstructures create temporary pores in cells March 27th, 2017

Researchers make flexible glass for tiny medical devices: Glass can bend over and over again on a nanoscale March 27th, 2017

Materials/Metamaterials

Researchers make flexible glass for tiny medical devices: Glass can bend over and over again on a nanoscale March 27th, 2017

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Rice U. refines filters for greener natural gas: New study defines best materials for carbon capture, methane selectivity March 23rd, 2017

Announcements

Information storage with a nanoscale twist: Discovery of a novel rotational force inside magnetic vortices makes it easier to design ultrahigh capacity disk drives March 28th, 2017

ATTOPSEMI Technology Joins FDXcelerator Program to Deliver Advanced Non-Volatile Memory IP to GLOBALFOUNDRIES 22 FDX Technology Platform: Leading-edge I-fuse brings higher reliability, smaller cell size and ease of programmability for consumer, automotive, and IoT applications March 27th, 2017

Leti and HORIBA Scientific to Host Webinar on Ultrafast Characterization Tool: Plasma Profiling Time-of-Flight Mass Spectrometer Tool Cuts Optimization Time In Layer Deposition and Fabrication of Wide Range of Applications March 27th, 2017

Laser activated gold pyramids could deliver drugs, DNA into cells without harm: Microstructures create temporary pores in cells March 27th, 2017

Nanobiotechnology

Laser activated gold pyramids could deliver drugs, DNA into cells without harm: Microstructures create temporary pores in cells March 27th, 2017

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project