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- New Research Shows Broad Spectrum of Light Absorption, from Ultraviolet (UV) to Near Infrared (NIR),
May Be Critical Step in Light-Based Cancer Therapies -
SouthWest NanoTechnologies' (SWeNT) Single-Wall Carbon Nanotubes (SWNTs), in a new research study, show absorption of Indocyanine Green (ICG) -- a functional dye with unique photomechanical, photochemical, and photobiological properties.
The ICG-SWNT complexes formed are sensitive to a broad spectrum of light, ranging from ultraviolet (UV) to near infrared (NIR), which may help unlock this novel nanosystem for use in potential applications in photothermal cancer therapies. According to the study published in Journal of X-Ray Science and Technology, researchers in China showed that, based on the ICG-SWT complexes sensitivity to a broad spectrum of light, "it is expected that an effective phototherapy is not limited to a single light source." This new research demonstrates the potential for future photothermal therapies in the spectrum of visible light.
"Photothermal therapy has been attracting greater attention," according to the authors. "Usually only a laser of single wavelength was used, such as 808nm, 980nm or 1064nm in treatments. Recently, it was shown that a 658nm laser within natural light spectrum coupled with nanoparticles could cause irreversible photothermal damage to tumors. However, with the increased concentration of SWNTs increase in our experiments, typical absorption peaks of ICG monomer (at 780nm) or dimer (at 700nm) were decreased and typical absorption peak of SWNT (at 1030nm) was increased. The researchers demonstrate that the absorption of ICG at 700nm and 780nm transformed the light affected SWNTs in the range of (UV) to near-infrared (NIR) regions. As a result, the increased absorption of SWNTs from UV to the NIR regions opens this novel nanosystem to potential applications in the photothermal cancer treatment.
"We're excited about the potential applications from this cutting-edge research that will hopefully yield new and exciting cancer therapies," explains SWeNT CEO Dave Arthur. "The number of biomedical research studies using our SWCNT continues to grow, pointing to new opportunities for SouthWest NanoTechnologies, Inc. as the world leader in high quality, Single-Wall and Specialty Multi-Wall (SMW™) carbon nanotubes."
The research was supported by the National Basic Research Program of China, the Program for Changjiang Scholars and Innovative Research Team in University and the National Natural Science Foundation of China.
"Noncovalent functionalization of single-walled carbon nanotubes by indocyanine green: Potential nanocomplexes for photothermal therapy"
Journal of -Ray Science and Technology
Xiaohui Zheng and Feifan Zhou
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of
Biophotonics, South China Normal University, Guangzhou, China
About SouthWest NanoTechnologies
SouthWest NanoTechnologies, Inc. (SWeNT) is a privately-held specialty chemical company that manufactures high quality Single-W all and Specialty Multi-Wall (SMW™) carbon nanotubes, printable inks and CNT-coated fabrics for a range of products and applications including energy-efficient lighting, affordable photovoltaics, improved energy storage and printed electronics. SWeNT was created in 2001 to spin off nanotube research developed at the University of Oklahoma.
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A. Lavin Communications
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