Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Penn Researchers Help Nanoscale Engineers Choose Self-Assembling Proteins

Abstract:
Engineering structures on the smallest possible scales - using molecules and individual atoms as building blocks - is both physically and conceptually challenging. An interdisciplinary team of researchers at the University of Pennsylvania has now developed a method of computationally selecting the best of these blocks, drawing inspiration from the similar behavior of proteins in making biological structures.

Penn Researchers Help Nanoscale Engineers Choose Self-Assembling Proteins

Philadelphia, PA | Posted on May 30th, 2011

The team was led by postdoctoral student Gevorg Grigoryan and professor William DeGrado of the Department of Biochemistry and Biophysics in Penn's Perelman School of Medicine, as well as graduate student Yong Ho Kim of the Department of Chemistry in Penn's School of Arts and Sciences. Their colleagues included members of the Department of Physics and Astronomy in SAS.

Their research was published in the journal Science today.

The team set out to design proteins that could wrap around single-walled carbon nanotubes. Consisting of a cylindrical pattern of carbon atoms tens of thousands of times thinner than a human hair, nanotubes are enticing to nanoengineers as they are extraordinarily strong and could be useful as platform for other nano-structures.

"We wanted to achieve a specific geometric pattern of the atoms that these proteins are composed of on the surface of the nanotube," Grigoryan said. "If you know the underlying atomic lattice, it means that you know how to further build around it, how to attach things to it. It's like scaffolding for future building."

The hurdle in making such scaffolds isn't a lack of information, but a surfeit of it: researchers have compiled databases that list hundreds of thousands of actual and potential protein structures in atomic detail. Picking the building materials for a particular structure from this vast array and assuring that they self-assemble into the desired shape was beyond the abilities of powerful computers, much less humans.

"There's just an enormous space of structural possibilities to weed through trying to figure out which are feasible," Grigoryan said. "To have a process that can do that quickly, that can look at a structure and say ‘that's not reasonable, that can't be built out of common units,' would solve that problem."

The researchers' algorithm works in three steps, which, given the parameters of the desired scaffolding, successively eliminate proteins that will not produce the right shape. The elimination criteria were based on traits like symmetry, periodicity of binding sites and similarity to protein "motifs" found in nature.

After separating the wheat from the chaff, the result is a list of thousands of candidate proteins. While still a daunting amount, the algorithm makes the protein selection process merely difficult, rather than impossible.

The research team tested their algorithm by designing a protein that would not only stably wrap around a nanotube in a helix but also provide a regular pattern on its exterior to which gold particles could be attached.

"You could use this to build a gold nanowire, for instance, or modulate the optical properties of the underlying tube in desired ways" Grigoryan said.

Next steps will include applying this algorithm for designing proteins that can attach to graphene, which is essentially an unrolled nanotube. Being able to make scaffolds out of customizable array of proteins in a variety of shapes could lead to advances in everything from miniaturization of circuitry to drug delivery.

Engineering these materials in the lab requires a tremendous amount of precision and computational power, but such efforts are essentially mimicking a phenomenon found in even the simplest forms of life.

"The kind of packing that certain viruses have in their viral envelope is similar to what we have here in that they self-assemble. They have protein units that, on their own, form their complicated structures with features that are far beyond the size of any single protein," Grigoryan said. "Each protein doesn't know what the final structure is going to be, but it still helps form it. We were inspired by that."

In addition to Grigoryan, DeGrado and Kim, researchers included Rudresh Acharya of the Department of Biochemistry and Biophysics in the Perelman School of Medicine and Kevin Axelrod, Rishabh M. Jain, Lauren Willis, Marija Drndic and James M. Kikkawa of the Department of Physics and Astronomy in SAS.

Their research was supported by the National Science Foundation and the National Institutes of Health.

####

For more information, please click here

Contacts:
Michael Bezilla
Director
Research Communications Group
(814) 865-9481


Lisa Powers
Director
Public Information
(814) 865-7517

Copyright © Penn State

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Govt.-Legislation/Regulation/Funding/Policy

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Molecular Nanotechnology

Tip-assisted chemistry enables chemical reactions at femtoliter scale November 16th, 2016

Scientists come up with light-driven motors to power nanorobots of the future: Researchers from Russia and Ukraine propose a nanosized motor controlled by a laser with potential applications across the natural sciences and medicine November 11th, 2016

New Book by Nobel Laureate Tells Story of Chemistry’s New Field: Fraser Stoddart explains the mechanical bond and where it is taking scientists November 11th, 2016

HKU chemists develop world's first light-seeking synthetic Nanorobot November 9th, 2016

Self Assembly

Computers made of genetic material? HZDR researchers conduct electricity using DNA-based nanowires November 9th, 2016

First multicellular organism inspires the design of better cancer drugs September 15th, 2016

A versatile method to pattern functionalized nanowires: A team of researchers from Hokkaido University has developed a versatile method to pattern the structure of 'nanowires,' providing a new tool for the development of novel nanodevices September 9th, 2016

Location matters in the self-assembly of nanoclusters: Iowa State University scientists have developed a new formulation to explain an aspect of the self-assembly of nanoclusters on surfaces that has broad applications for nanotechnology September 8th, 2016

Nanotubes/Buckyballs/Fullerenes

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Cutting-edge nanotechnologies are breaking into industries November 18th, 2016

Hybrid nanostructures hold hydrogen well: Rice University scientists say boron nitride-graphene hybrid may be right for next-gen green cars October 25th, 2016

Self-healable battery Lithium ion battery for electronic textiles grows back together after breaking October 20th, 2016

Announcements

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Research partnerships

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Novel silicon etching technique crafts 3-D gradient refractive index micro-optics November 28th, 2016

Single photon converter -- a key component of quantum internet November 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project