Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Penn Researchers Help Nanoscale Engineers Choose Self-Assembling Proteins

Abstract:
Engineering structures on the smallest possible scales - using molecules and individual atoms as building blocks - is both physically and conceptually challenging. An interdisciplinary team of researchers at the University of Pennsylvania has now developed a method of computationally selecting the best of these blocks, drawing inspiration from the similar behavior of proteins in making biological structures.

Penn Researchers Help Nanoscale Engineers Choose Self-Assembling Proteins

Philadelphia, PA | Posted on May 30th, 2011

The team was led by postdoctoral student Gevorg Grigoryan and professor William DeGrado of the Department of Biochemistry and Biophysics in Penn's Perelman School of Medicine, as well as graduate student Yong Ho Kim of the Department of Chemistry in Penn's School of Arts and Sciences. Their colleagues included members of the Department of Physics and Astronomy in SAS.

Their research was published in the journal Science today.

The team set out to design proteins that could wrap around single-walled carbon nanotubes. Consisting of a cylindrical pattern of carbon atoms tens of thousands of times thinner than a human hair, nanotubes are enticing to nanoengineers as they are extraordinarily strong and could be useful as platform for other nano-structures.

"We wanted to achieve a specific geometric pattern of the atoms that these proteins are composed of on the surface of the nanotube," Grigoryan said. "If you know the underlying atomic lattice, it means that you know how to further build around it, how to attach things to it. It's like scaffolding for future building."

The hurdle in making such scaffolds isn't a lack of information, but a surfeit of it: researchers have compiled databases that list hundreds of thousands of actual and potential protein structures in atomic detail. Picking the building materials for a particular structure from this vast array and assuring that they self-assemble into the desired shape was beyond the abilities of powerful computers, much less humans.

"There's just an enormous space of structural possibilities to weed through trying to figure out which are feasible," Grigoryan said. "To have a process that can do that quickly, that can look at a structure and say ‘that's not reasonable, that can't be built out of common units,' would solve that problem."

The researchers' algorithm works in three steps, which, given the parameters of the desired scaffolding, successively eliminate proteins that will not produce the right shape. The elimination criteria were based on traits like symmetry, periodicity of binding sites and similarity to protein "motifs" found in nature.

After separating the wheat from the chaff, the result is a list of thousands of candidate proteins. While still a daunting amount, the algorithm makes the protein selection process merely difficult, rather than impossible.

The research team tested their algorithm by designing a protein that would not only stably wrap around a nanotube in a helix but also provide a regular pattern on its exterior to which gold particles could be attached.

"You could use this to build a gold nanowire, for instance, or modulate the optical properties of the underlying tube in desired ways" Grigoryan said.

Next steps will include applying this algorithm for designing proteins that can attach to graphene, which is essentially an unrolled nanotube. Being able to make scaffolds out of customizable array of proteins in a variety of shapes could lead to advances in everything from miniaturization of circuitry to drug delivery.

Engineering these materials in the lab requires a tremendous amount of precision and computational power, but such efforts are essentially mimicking a phenomenon found in even the simplest forms of life.

"The kind of packing that certain viruses have in their viral envelope is similar to what we have here in that they self-assemble. They have protein units that, on their own, form their complicated structures with features that are far beyond the size of any single protein," Grigoryan said. "Each protein doesn't know what the final structure is going to be, but it still helps form it. We were inspired by that."

In addition to Grigoryan, DeGrado and Kim, researchers included Rudresh Acharya of the Department of Biochemistry and Biophysics in the Perelman School of Medicine and Kevin Axelrod, Rishabh M. Jain, Lauren Willis, Marija Drndic and James M. Kikkawa of the Department of Physics and Astronomy in SAS.

Their research was supported by the National Science Foundation and the National Institutes of Health.

####

For more information, please click here

Contacts:
Michael Bezilla
Director
Research Communications Group
(814) 865-9481


Lisa Powers
Director
Public Information
(814) 865-7517

Copyright © Penn State

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

New research points to graphene as a flexible, low-cost touchscreen solution September 19th, 2014

Govt.-Legislation/Regulation/Funding/Policy

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Big Results Require Big Ambitions: Three young UCSB faculty receive CAREER awards from the National Science Foundation September 18th, 2014

Scientists refine formula for nanotube types: Rice University theorists determine factors that give tubes their chiral angles September 17th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Molecular Nanotechnology

Nanoscale assembly line August 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster: University of Leicester research team unlocks insights into creation of new nano-materials July 25th, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Self Assembly

Big Results Require Big Ambitions: Three young UCSB faculty receive CAREER awards from the National Science Foundation September 18th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Molecular self-assembly controls graphene-edge configuration September 10th, 2014

Rice chemist wins rare NSF Special Creativity Award: Grant extension will bolster Zubarev's effort to produce gold nanorods September 8th, 2014

Nanotubes/Buckyballs

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Scientists refine formula for nanotube types: Rice University theorists determine factors that give tubes their chiral angles September 17th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Announcements

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

New research points to graphene as a flexible, low-cost touchscreen solution September 19th, 2014

Research partnerships

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

Carbon Sciences Developing Breakthrough Technology to Mass-Produce Graphene -- the New Miracle Material: Company Enters Into an Agreement With the University of California, Santa Barbara (UCSB) to Fund the Further Development of a New Graphene Process September 16th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE