Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Penn Researchers Help Nanoscale Engineers Choose Self-Assembling Proteins

Abstract:
Engineering structures on the smallest possible scales - using molecules and individual atoms as building blocks - is both physically and conceptually challenging. An interdisciplinary team of researchers at the University of Pennsylvania has now developed a method of computationally selecting the best of these blocks, drawing inspiration from the similar behavior of proteins in making biological structures.

Penn Researchers Help Nanoscale Engineers Choose Self-Assembling Proteins

Philadelphia, PA | Posted on May 30th, 2011

The team was led by postdoctoral student Gevorg Grigoryan and professor William DeGrado of the Department of Biochemistry and Biophysics in Penn's Perelman School of Medicine, as well as graduate student Yong Ho Kim of the Department of Chemistry in Penn's School of Arts and Sciences. Their colleagues included members of the Department of Physics and Astronomy in SAS.

Their research was published in the journal Science today.

The team set out to design proteins that could wrap around single-walled carbon nanotubes. Consisting of a cylindrical pattern of carbon atoms tens of thousands of times thinner than a human hair, nanotubes are enticing to nanoengineers as they are extraordinarily strong and could be useful as platform for other nano-structures.

"We wanted to achieve a specific geometric pattern of the atoms that these proteins are composed of on the surface of the nanotube," Grigoryan said. "If you know the underlying atomic lattice, it means that you know how to further build around it, how to attach things to it. It's like scaffolding for future building."

The hurdle in making such scaffolds isn't a lack of information, but a surfeit of it: researchers have compiled databases that list hundreds of thousands of actual and potential protein structures in atomic detail. Picking the building materials for a particular structure from this vast array and assuring that they self-assemble into the desired shape was beyond the abilities of powerful computers, much less humans.

"There's just an enormous space of structural possibilities to weed through trying to figure out which are feasible," Grigoryan said. "To have a process that can do that quickly, that can look at a structure and say ‘that's not reasonable, that can't be built out of common units,' would solve that problem."

The researchers' algorithm works in three steps, which, given the parameters of the desired scaffolding, successively eliminate proteins that will not produce the right shape. The elimination criteria were based on traits like symmetry, periodicity of binding sites and similarity to protein "motifs" found in nature.

After separating the wheat from the chaff, the result is a list of thousands of candidate proteins. While still a daunting amount, the algorithm makes the protein selection process merely difficult, rather than impossible.

The research team tested their algorithm by designing a protein that would not only stably wrap around a nanotube in a helix but also provide a regular pattern on its exterior to which gold particles could be attached.

"You could use this to build a gold nanowire, for instance, or modulate the optical properties of the underlying tube in desired ways" Grigoryan said.

Next steps will include applying this algorithm for designing proteins that can attach to graphene, which is essentially an unrolled nanotube. Being able to make scaffolds out of customizable array of proteins in a variety of shapes could lead to advances in everything from miniaturization of circuitry to drug delivery.

Engineering these materials in the lab requires a tremendous amount of precision and computational power, but such efforts are essentially mimicking a phenomenon found in even the simplest forms of life.

"The kind of packing that certain viruses have in their viral envelope is similar to what we have here in that they self-assemble. They have protein units that, on their own, form their complicated structures with features that are far beyond the size of any single protein," Grigoryan said. "Each protein doesn't know what the final structure is going to be, but it still helps form it. We were inspired by that."

In addition to Grigoryan, DeGrado and Kim, researchers included Rudresh Acharya of the Department of Biochemistry and Biophysics in the Perelman School of Medicine and Kevin Axelrod, Rishabh M. Jain, Lauren Willis, Marija Drndic and James M. Kikkawa of the Department of Physics and Astronomy in SAS.

Their research was supported by the National Science Foundation and the National Institutes of Health.

####

For more information, please click here

Contacts:
Michael Bezilla
Director
Research Communications Group
(814) 865-9481


Lisa Powers
Director
Public Information
(814) 865-7517

Copyright © Penn State

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanofur for oil spill cleanup: Materials researchers learn from aquatic ferns: Hairy plant leaves are highly oil-absorbing / publication in bioinspiration & biomimetics / video on absorption capacity August 25th, 2016

Unraveling the crystal structure of a -70° Celsius superconductor, a world first: Significant advancement in the realization of room-temperature superconductors August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Light and matter merge in quantum coupling: Rice University physicists probe photon-electron interactions in vacuum cavity experiments August 24th, 2016

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

Molecular Nanotechnology

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

DNA dominos on a chip: Carriers of genetic information packed together on a biochip like in nature August 11th, 2016

Smarter self-assembly opens new pathways for nanotechnology: Brookhaven Lab scientists discover a way to create billionth-of-a-meter structures that snap together in complex patterns with unprecedented efficiency August 9th, 2016

New remote-controlled microrobots for medical operations July 23rd, 2016

Self Assembly

Smarter self-assembly opens new pathways for nanotechnology: Brookhaven Lab scientists discover a way to create billionth-of-a-meter structures that snap together in complex patterns with unprecedented efficiency August 9th, 2016

Magnetic atoms arranged in neat rows: FAU physicists enable one-dimensional atom chains to grow August 5th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

WSU researchers develop shape-changing 'smart' material: Heat, light stimulate self-assembly July 4th, 2016

Nanotubes/Buckyballs/Fullerenes

Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes August 24th, 2016

McMaster researchers resolve a problem that has been holding back a technological revolution August 18th, 2016

'Second skin' protects soldiers from biological and chemical agents August 5th, 2016

Carbon nanotube 'stitches' make stronger, lighter composites: Method to reinforce these materials could help make airplane frames lighter, more damage-resistant August 4th, 2016

Announcements

AIM Photonics Announces Release of Process Design Kit (PDK) for Integrated Silicon Photonics Design August 25th, 2016

Semblant to Present at China Mobile Manufacturing Forum 2016 August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Research partnerships

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Researchers watch catalysts at work August 19th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic