Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Grant to SDSU researcher will address congestive heart failure

John M. Robinson MD, PhD., Assistant Professor
John M. Robinson MD, PhD., Assistant Professor

Abstract:
A grant of about $1.8 million over five years will help scientists better understand congestive heart failure, a condition that affects 5.7 million Americans annually.

Grant to SDSU researcher will address congestive heart failure

Brookings, SD | Posted on December 21st, 2010

John Robinson, a medical doctor and biophysicist at South Dakota State University, has been awarded the funding by the Heart, Lung and Blood Institute of the National Institutes of Health. The research could supply new knowledge about heart failure that could lead to new treatment strategies.

The risk of congestive heart failure increases sharply with age, doubling every 10 years among older adults. At younger ages, blacks are disproportionately affected compared to whites by a ratio of 20 to 1.

Robinson, a member of the Department of Chemistry and Biochemistry in SDSU's College of Arts and Sciences, is especially interested in heart failure in connection with impaired function of the myofilament, a protein assembly regulated by calcium that makes the heart contract.

"The myofilament is the fundamental unit that allows the heart to generate force. Your heart has to beat and relax about once every second," Robinson said. "These periods of contraction and relaxation are regulated by the levels of calcium inside cells of the heart. The myofilament is a calcium-sensitive switch that generates force when calcium binds to it."

However, scientists don't fully understand how the myofilament functions or what goes wrong when it doesn't work properly. Robinson said that's because those processes are taking place at the nanoscale, or roughly at a level 100 to 1,000 times smaller than can be seen by using a conventional microscope.

"Switching in the nanoscale is very different from switching in our world. If I turn a light switch on, it stays on," Robinson said. "What we're seeing with protein switches is that just because calcium binds to it, it will not necessarily turn on. It's sort of error-prone. All of the switching is done by heat random collisions with water is what drives all of this."

Robinson said a revolution in instrumentation is making it possible to unravel such processes, some of which have been studied for decades. Robinson is part of the SDSU-based Center for Biological Control and Analysis by Applied Photonics, or BCAAP. The center is made up of researchers who use light as one of the tools either to control biochemical processes or, in this case, to analyze biochemical processes.

Robinson's laboratory uses a technique called Fluorescence Resonance Energy Transfer, or FRET, to study proteins at the nanoscale. His FRET measurements are at the "single molecule" level, studying myofilaments one at a time.

Robinson's five-year NIH project will work to establish what molecular interactions are taking place as the myofilament contracts; and to understand the mechanisms at work when myofilaments' sensitivity to calcium is altered.

####

For more information, please click here

Copyright © South Dakota State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Looking for the quantum frontier: Beyond classical computing without fault-tolerance? April 27th, 2017

Metal nanoparticles induced visible-light photocatalysis: Mechanisms, applications, ways of promoting catalytic activity and outlook April 27th, 2017

Arrowhead Pharmaceuticals to Webcast Fiscal 2017 Second Quarter Results April 27th, 2017

California Research Alliance by BASF establishes more than 25 research projects in three years April 26th, 2017

Govt.-Legislation/Regulation/Funding/Policy

Metal nanoparticles induced visible-light photocatalysis: Mechanisms, applications, ways of promoting catalytic activity and outlook April 27th, 2017

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Academic/Education

California Research Alliance by BASF establishes more than 25 research projects in three years April 26th, 2017

SUNY Polytechnic Institute Announces Total of 172 Teams Selected to Compete in Solar in Your Community Challenge: Teams from 40 states, plus Washington, DC, 2 Territories, and 4 American Indian Reservations, Will Deploy Solar in Underserved Communities April 20th, 2017

Rice crew revved for Nanocar Race: Nanocar creator James Tour and team take on international competition with single-molecule marvel April 20th, 2017

The Catholic University of Rome uses the JPK NanoWizardŽ AFM & CellHesionŽ systems to understand how cells sense and respond to mechanical stimuli April 5th, 2017

Nanomedicine

Arrowhead Pharmaceuticals to Webcast Fiscal 2017 Second Quarter Results April 27th, 2017

New Product Nanoparticle preparation from Intertronics with new Thinky NP-100 Nano Pulveriser April 26th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Announcements

Looking for the quantum frontier: Beyond classical computing without fault-tolerance? April 27th, 2017

Metal nanoparticles induced visible-light photocatalysis: Mechanisms, applications, ways of promoting catalytic activity and outlook April 27th, 2017

Arrowhead Pharmaceuticals to Webcast Fiscal 2017 Second Quarter Results April 27th, 2017

Video captures bubble-blowing battery in action: Researchers propose how bubbles form, could lead to smaller lithium-air batteries April 26th, 2017

Tools

New Product Nanoparticle preparation from Intertronics with new Thinky NP-100 Nano Pulveriser April 26th, 2017

Affordable STM32 Cloud-Connectable Kit from STMicroelectronics Puts More Features On-Board for Fast and Flexible IoT-Device Development April 26th, 2017

Geoffrey Beach: Drawn to explore magnetism: Materials researcher is working on the magnetic memory of the future April 25th, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Nanobiotechnology

Arrowhead Pharmaceuticals to Webcast Fiscal 2017 Second Quarter Results April 27th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project