Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > UCSF unveils model for implantable artificial kidney to replace dialysis

A model of the implantable bioartificial kidney shows the two-stage system. Thousands of nanoscale filters remove toxins from the blood, while a BioCartridge of renal tubule cells mimics the metabolic and water-balance roles of the human kidney.
A model of the implantable bioartificial kidney shows the two-stage system. Thousands of nanoscale filters remove toxins from the blood, while a BioCartridge of renal tubule cells mimics the metabolic and water-balance roles of the human kidney.

Abstract:
UCSF researchers today unveiled a prototype model of the first implantable artificial kidney, in a development that one day could eliminate the need for dialysis.

UCSF unveils model for implantable artificial kidney to replace dialysis

San Francisco, CA | Posted on September 6th, 2010

The device, which would include thousands of microscopic filters as well as a bioreactor to mimic the metabolic and water-balancing roles of a real kidney, is being developed in a collaborative effort by engineers, biologists and physicians nationwide, led by Shuvo Roy, PhD, in the UCSF Department of Bioengineering and Therapeutic Sciences.

The treatment has been proven to work for the sickest patients using a room-sized external model developed by a team member in Michigan. Roy's goal is to apply silicon fabrication technology, along with specially engineered compartments for live kidney cells, to shrink that large-scale technology into a device the size of a coffee cup. The device would then be implanted in the body without the need for immune suppressant medications, allowing the patient to live a more normal life.

"This device is designed to deliver most of the health benefits of a kidney transplant, while addressing the limited number of kidney donors each year," said Roy, an associate professor in the UCSF School of Pharmacy who specializes in developing micro-electromechanical systems (MEMS) technology for biomedical applications. "This could dramatically reduce the burden of renal failure for millions of people worldwide, while also reducing one of the largest costs in U.S. healthcare."

The team has established the feasibility of an implantable model in animal models and plans to be ready for clinical trials in five to seven years.

End-stage renal disease, or chronic kidney failure, affects more than 500,000 people per year in the United States alone, and currently is only fully treated with a kidney transplant. That number has been rising between 5-7 percent per year, Roy said, in part because of the kidney damage associated with diabetes and hypertension.

Yet transplants are difficult to obtain: a mere 17,000 donated kidneys were available for transplant last year, while the number of patients on the transplant waiting list currently exceeds 85,000, according to the Organ Procurement ant Transplant Network.

Roughly 350,000 patients are reliant on kidney dialysis, Roy explained, which comes at a tremendous cost. The Medicare system alone spends $25 billion on treatments for kidney failure - more than 6 percent of the total budget - while the disease affects only 1 percent of Medicare recipients, he said. That cost includes almost $75,000 per patient each year for dialysis, according to the U.S. Renal Data System.

Dialysis also takes a human toll. A typical dialysis schedule is three sessions per week, for 3 to 5 hours per session, in which blood is pumped through an external circuit for filtration. This is exhausting for patients and only replaces 13 percent of kidney function, Roy said. As a result, only 35 percent of patients survive for more than 5 years.

With the limited supply of donors, that means thousands of patients die each year waiting for a kidney.

The implantable device aims to eradicate that problem. The two-stage system uses a hemofilter to remove toxins from the blood, while applying recent advances in tissue engineering to grow renal tubule cells to provide other biological functions of a healthy kidney. The process relies on the body's blood pressure to perform filtration without needing pumps or an electrical power supply.

The project exemplifies the many efforts under way at UCSF to build collaborations across scientific disciplines that accelerate the translation of academic research into real solutions for patients, according to Mary Anne Koda-Kimble, PharmD, dean of the UCSF School of Pharmacy.

"This is a perfect example of the work we are doing at UCSF to address some of the most critical medical issues of our time, both in human and financial costs," Koda-Kimble said. "This project shows what can be accomplished by teams of scientists with diverse expertise, collaborating to profoundly and more quickly improve the lives of patients worldwide."

The creation of the Department of Bioengineering and Therapeutic Sciences - a joint department in the UCSF schools of Pharmacy and Medicine - was itself an effort to promote translational research at UCSF by forming collaborations across biomedical specialties. Roy is also a founding faculty member of the UCSF Pediatric Device Consortium, which aims to accelerate the development of innovative devices for children health, and a faculty affiliate of the California Institute for Quantitative Biosciences (QB3) at UCSF.

His team is collaborating with 10 other teams of researchers on the project, including the Cleveland Clinic where Roy initially developed the idea, Case Western Reserve University, University of Michigan, Ohio State University, and Penn State University.

The first phase of the project, which has already been completed, focused on developing the technologies required to reduce the device to a size that could fit into the body and testing the individual components in animal models. In the second and current phase, the team is doing the sophisticated work needed to scale up the device for humans. The team now has the components and a visual model and is pursuing federal and private support to bring the project to clinical use.

####

About University of California, San Francisco
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

For more information, please click here

Contacts:
Kristen Bole

(415) 502-NEWS (6397)

Copyright © University of California, San Francisco

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

An EPiQS Pursuit: Physicist Andrea Young is chosen to receive an Experimental Investigator award from the Moore Foundation May 28th, 2020

Study finds electrical fields can throw a curveball: Particle-scale phenomenon akin to the swerving of a curveball could allow selective separation of suspended nanomaterials May 26th, 2020

Surrey reveals its implantable biosensor that operates without batteries May 22nd, 2020

Researchers demonstrate transport of mechanical energy, even through damaged pathways: Topological pump can provide stability for communication technologies May 22nd, 2020

Possible Futures

An EPiQS Pursuit: Physicist Andrea Young is chosen to receive an Experimental Investigator award from the Moore Foundation May 28th, 2020

Study finds electrical fields can throw a curveball: Particle-scale phenomenon akin to the swerving of a curveball could allow selective separation of suspended nanomaterials May 26th, 2020

Visualization of functional components to characterize optimal composite electrodes May 22nd, 2020

Researchers demonstrate transport of mechanical energy, even through damaged pathways: Topological pump can provide stability for communication technologies May 22nd, 2020

Academic/Education

Matching Investment Program (MIP) Leverages $140K Empire State Development/NYSTAR Funding to SUNY Poly’s CATN2 to Enable $1.5M in Matching Commitments from Industry Partners: Investment Funds Faculty Research Related to Advanced Materials, Genomics, and Semiconductor Reliability October 18th, 2019

A Quantum Leap: $25M grant makes UC Santa Barbara home to the nation’s first NSF-funded Quantum Foundry, a center for development of materials for quantum information-based technologies September 16th, 2019

LPU signs MoU with Bruker India for Research Cooperation in Nanotechnology and Material Science September 3rd, 2019

RIT to upgrade Semiconductor and Microsystems Fabrication Laboratory through $1 million state grant: Upgrades to clean room will enhance university’s research capabilities in photonics, quantum technologies and smart systems August 16th, 2019

MEMS

CEA-Leti Develops Tiny Photoacoustic-Spectroscopy System For Detecting Chemicals & Gases: Paper at Photonics West to Present Detector that Could Cost 10x Less Than Existing Systems and Prompt Widespread Use of the Technology February 4th, 2020

MEMS & Sensors Executive Congress Technology Showcase Finalists Highlight Innovations in Automotive, Biomedical and Consumer Electronics: MSIG MEMS & Sensors Executive Congress – October 22-24, 2019, Coronado, Calif. October 1st, 2019

ULVAC Launches Revolutionary PZT Piezoelectric Thin-film Process Technology and HVM Solution for MEMS Sensors/Actuators: Enabling Reliable, High-quality Film Production for Next Generation Devices August 16th, 2019

New Video Highlights Specific Topics Sought in Call for Papers for the 2019 IEEE International Electron Devices Meeting (IEDM) June 13th, 2019

Nanomedicine

2D sandwich sees molecules with clarity: Rice University engineers adapt 2D ‘sandwich’ for surface-enhanced Raman spectroscopy May 15th, 2020

Twisting 2D materials uncovers their superpowers: Researchers have developed a completely new method for twisting atomically thin materials, paving the way for applications of 'twistronics' based on tunable 2D materials May 12th, 2020

Chemistry breakthrough could speed up drug development: Scientists have successfully developed a new technique to reliably grow crystals of organic soluble molecules from nanoscale droplets, unlocking the potential of accelerated new drug development May 8th, 2020

Engineers and scientists develop mobile technology for eye examinations: Novel photonic integrated technology will bring optical coherence tomography from stationary clinical use to mobile use May 7th, 2020

Announcements

An EPiQS Pursuit: Physicist Andrea Young is chosen to receive an Experimental Investigator award from the Moore Foundation May 28th, 2020

Study finds electrical fields can throw a curveball: Particle-scale phenomenon akin to the swerving of a curveball could allow selective separation of suspended nanomaterials May 26th, 2020

Visualization of functional components to characterize optimal composite electrodes May 22nd, 2020

Researchers demonstrate transport of mechanical energy, even through damaged pathways: Topological pump can provide stability for communication technologies May 22nd, 2020

Nanobiotechnology

2D sandwich sees molecules with clarity: Rice University engineers adapt 2D ‘sandwich’ for surface-enhanced Raman spectroscopy May 15th, 2020

Chemistry breakthrough could speed up drug development: Scientists have successfully developed a new technique to reliably grow crystals of organic soluble molecules from nanoscale droplets, unlocking the potential of accelerated new drug development May 8th, 2020

Arrowhead Pharmaceuticals to Participate in Upcoming May 2020 Conferences May 1st, 2020

Arrowhead Pharmaceuticals Announces Retirement of COO Bruce Given May 1st, 2020

Research partnerships

Surrey reveals its implantable biosensor that operates without batteries May 22nd, 2020

Scientists use light to accelerate supercurrents, access forbidden light, quantum world May 21st, 2020

Observation of intervalley transitions can boost valleytronic science and technology: UC Riverside-led research shows these transitions can emit light May 15th, 2020

Scientists break the link between a quantum material's spin and orbital states: The advance opens a path toward a new generation of logic and memory devices based on orbitronics that could be 10,000 times faster than today's May 15th, 2020

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project