Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Researchers Use Nanoparticles as Destructive Beacons to Zap Tumors

Abstract:
A group of researchers from Wake Forest University Baptist Medical Center (WFUBMC) is developing a way to treat cancer by using lasers to light up tiny nanoparticles and destroy tumors with the ensuing heat.

Researchers Use Nanoparticles as Destructive Beacons to Zap Tumors

Winston-Salem, NC | Posted on July 26th, 2010

Today at the 52nd Annual Meeting of the American Association of Physicists in Medicine (AAPM) in Philadelphia, they will describe the latest development for this technology: iron-containing Multi-Walled Carbon Nanotubes (MWCNTs) -- threads of hollow carbon that are 10 thousand times thinner than a human hair.

In laboratory experiments, the team showed that by using an MRI scanner, they could image these particles in living tissue, watch as they approached a tumor, zap them with a laser, and destroy the tumor in the process.

If this sounds like science fiction, it is not. The work builds on an experimental technique for treating cancer called laser-induced thermal therapy (LITT), which uses energy from lasers to heat and destroy tumors. LITT works by virtue of the fact that certain nanoparticles like MWCNTs can absorb the energy of a laser and then convert it into heat. If the nanoparticles are zapped while within a tumor, they will boil off the energy as heat and kill the cancerous cells.

The problem with LITT, however, is that while a tumor may be clearly visible in a medical scan, the particles are not. They cannot be tracked once injected, which could put a patient in danger if the nanoparticles were zapped away from the tumor because the aberrant heating could destroy healthy tissue.

Now the team from Wake Forest Baptist has shown for the first time that it is possible to make the particles visible in the MRI scanner to allow imaging and heating at the same time. By loading the MWCNT particles with iron, they become visible in an MRI scanner. Using tissue containing mouse tumors, they showed that these iron-containing MWCNT particles could destroy the tumors when hit with a laser.

"To find the exact location of the nanoparticle in the human body is very important to the treatment," says Xuanfeng Ding, M.S., who is presenting the work today in Philadelphia. "It is really exciting to watch the tumor labeled with the nanotubes begin to shrink after the treatment."

The results are part of Ding's ongoing Ph.D. thesis work -- a multi-disciplinary project led by Suzy Torti, Ph.D., professor of biochemistry at Wake Forest Baptist, and David Carroll, Ph.D., director of the Wake Forest University Center for Nanotechnology and Molecular Materials, that also includes the WFUBMC Departments of Physics, Radiation Oncology, Cancer Biology, and Biochemistry.

A previous study by the same group showed that laser-induced thermal therapy using a closely-related nanoparticle actually increased the long-term survival of mice with tumors. The next step in this project is to see if the iron-loaded nanoparticles can do the same thing.

If the work proves successful, it may one day help people with cancer, though the technology would have to prove safe and effective in clinical trials.

Dan Bourland, Ph.D., associate professor of radiation oncology and Ding's advisor, praises the high quality of Ding's work and says that the project is a strong example of today's "team science" that is needed for success in the biomedical fields.

####

For more information, please click here

Contacts:
Jessica Guenzel

336-716-3487

Bonnie Davis

336-716-4977

Copyright © Wake Forest University Baptist Medical Center

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

The 16th Trends in Nanotechnology International Conference (TNT 2015) unveils 25 Keynote Speakers: Call for abstracts open April 27th, 2015

Graphenea celebrates fifth anniversary April 27th, 2015

Sensor Designed in Iran Able to Remove Formaldehyde Gas from Environment April 27th, 2015

Possible Futures

Printing Silicon on Paper, with Lasers April 21st, 2015

A glass fiber that brings light to a standstill: By coupling photons to atoms, light in a glass fiber can be slowed down to the speed of an express train; for a short while it can even be brought to a complete stop April 9th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Academic/Education

SEFCU, SUNY Poly CNSE Announce Winning Student-Led Teams in the 6th Annual $500,000 New York Business Plan Competition April 25th, 2015

Iranian Female Professor Awarded UNESCO Medal in Nanoscience April 20th, 2015

JPK reports on the use of the NanoWizardŽ 3 AFM system at the Hebrew University of Jerusalem April 14th, 2015

UK National Graphene Institute Selects Bruker as Official Partner: World-Leading Graphene Research Facility Purchases Multiple Bruker AFMs April 7th, 2015

Nanotubes/Buckyballs/Fullerenes

SouthWest NanoTechnologies CEO Dave Arthur to Speak at NanoBCA DC Roundtable on May 19 in Washington DC April 20th, 2015

How to maximize the superconducting critical temperature in a molecular superconductor: International team led by Tohoku University opens new route for discovering high Tc superconductors April 19th, 2015

Nanotubes with two walls have singular qualities: Rice University lab calculates unique electronic qualities of double-walled carbon nanotubes April 16th, 2015

MIT sensor detects spoiled meat: Tiny device could be incorporated into 'smart packaging' to improve food safety April 15th, 2015

Nanomedicine

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

Announcements

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

The 16th Trends in Nanotechnology International Conference (TNT 2015) unveils 25 Keynote Speakers: Call for abstracts open April 27th, 2015

Graphenea celebrates fifth anniversary April 27th, 2015

Sensor Designed in Iran Able to Remove Formaldehyde Gas from Environment April 27th, 2015

Nanobiotechnology

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Scientists Use Nanoscale Building Blocks and DNA 'Glue' to Shape 3D Superlattices: New approach to designing ordered composite materials for possible energy applications April 23rd, 2015

UCLA nanoscientists are first to model atomic structures of three bacterial nanomachines: Cryo electron microscope enables scientists to explore the frontiers of targeted antibiotics April 21st, 2015

Photonics/Optics/Lasers

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

ORNL reports method that takes quantum sensing to new level April 23rd, 2015

Quantum 'paparazzi' film photons in the act of pairing up April 22nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project