Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Penn-Led Collaboration Mimics Library of Bio-Membranes for Use In Nanomedicine, Drug Delivery

Cryo-TEM and 3-D intensity profiles of (A and D) polygonal dendrimersomes. (B and E) Bicontinuous cubic particles co-exist with low concentration of spherical dendrimersomes. (C and F) Micelles. (G and J) Tubular dendrimersomes. (H and K) Rodlike, ribbon and helical micelles. (I and L) Disk-like micelles and toroids. Credit: University of Pennsylvania
Cryo-TEM and 3-D intensity profiles of (A and D) polygonal dendrimersomes. (B and E) Bicontinuous cubic particles co-exist with low concentration of spherical dendrimersomes. (C and F) Micelles. (G and J) Tubular dendrimersomes. (H and K) Rodlike, ribbon and helical micelles. (I and L) Disk-like micelles and toroids. Credit: University of Pennsylvania

Abstract:
An international collaboration led by chemists and engineers from the University of Pennsylvania has prepared a library of synthetic biomaterials that mimic cellular membranes and that show promise in targeted delivery of cancer drugs, gene therapy, proteins, imaging and diagnostic agents and cosmetics safely to the body in the emerging field called nanomedicine.

The study appears in the current issue of the journal Science.

Penn-Led Collaboration Mimics Library of Bio-Membranes for Use In Nanomedicine, Drug Delivery

Philadelphia, PA | Posted on May 22nd, 2010

The research provides the first description of the preparation, structure, self-assembly and mechanical properties of vesicles and other selected complex nano-assemblies made from Janus dendrimers.

The so-called dendrimersomes are stable, bilayer vesicles that spontaneously form from the exact chemical composition of Janus dendrimers. The team reported a myriad of bilayer capsule populations, uniform in size, stable in time in a large variety of media and temperatures, that are tunable by temperature and chemistry with superior mechanical properties to regular liposomes and impermeable to encapsulated compounds. They are capable of incorporating pore-forming proteins, can assemble with structure-directing phospholipids and block copolymers and offer a molecular periphery suitable for chemical functionalization without affecting their self-assembly.

Co-authors Virgil Percec of Penn's Department of Chemistry and Daniel A. Hammer of Penn's Department of Bioengineering, joined by Frank Bates and Timothy Lodge of the University of Minnesota, Michael Klein of Temple University and Kari Rissanen of the Jyväskylä University, in Finland, have chemically coupled hydrophilic and hydrophobic dendrons to create amphiphilic Janus dendrimers with a rich palette of morphologies including cubosomes, disks, tubular vesicles and helical ribbons and confirmed the assembled structures using cryogenic transmission electron microscopy and fluorescence microscopy.

"Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes, vesicles made from block copolymers, with the biological function of stabilized phospholipid liposomes," said Percec, the P. Roy Vagelos Chair and Professor of Chemistry at Penn, "but with superior uniformity of size, ease of formation and chemical functionalization."

"These materials show special promise because their membranes are the thickness of natural bilayer membranes, but they have superior and tunable materials properties," said Hammer, the Alfred G. and Meta A. Ennis Professor of Bioengineering at Penn. "Because of their membrane thickness, it will be more straightforward to incorporate biological components into the vesicle membranes, such as receptors and channels."

"No other single class of molecules including block copolymers and lipids is known to assemble in water into such a diversity of supramolecular structures," said Bates, the Regents Professor and Head of the Chemical Engineering and Materials Science Department at the University of Minnesota.

Self-assembled nanostructures, obtained from natural and synthetic amphiphiles, increasingly serve as mimics of biological membranes and enable the targeted delivery of drugs, nucleic acids, proteins, gene therapy and imaging agents for diagnostic medicine. The challenge for researchers is creating these precise molecular arrangements that combine to function as safe biological carriers while carrying payload within.

Janus dendrimer assemblies offer several advantages to other competing technologies for nano-particle delivery. Liposomes are mimics of cell membranes assembled from natural phospholipids or from synthetic amphiphiles, including polymersomes. But, liposomes are not stable, even at room temperature, and vary widely in size, requiring tedious stabilization and fractionation for all practical applications. Polymersomes, on the other hand, are stable but polydisperse, and most of them are not biocompatible, requiring scientific intervention to combine the best properties of both for nanomedicine. Dendrimersomes offer stability, monodispersity, tenability and versatility, and they significantly advance the science of self-assembled nanostructures for biological and medical applications.

The study was conducted by Percec, Daniela A. Wilson, Pawaret Leowanawat, Christopher J. Wilson, Andrew D. Hughes, Emad Aqad, Brad M. Rosen, Andreea O. Argintaru, Monika J. Sienkowska and Mark S. Kaucher of Penn's Department of Chemistry; Hammer of the Department of Bioengineering, the Department of Chemical and Biomolecular Engineering and the Institute for Medicine and Engineering at Penn; Dalia H. Levine and Anthony J. Kim of Penn's Department of Chemical and Biomolecular Engineering; Bates, Kevin P. Davis and Timothy P. Lodge of the University of Minnesota; Michael L. Klein and Russell H. DeVane of Temple University; Kari Rissanen and Jarmo Ropponen of the University of Jyväskylä in Finland; and Sami Nummelin of the University of Jyväskylä and Aalto University, both in Finland.

Research was funded by National Science Foundation-funded grants at the University of Pennsylvania and the University of Minnesota, as well as by the Academy of Finland, Temple University and the P. Roy Vagelos Chair at the University of Pennsylvania.

####

For more information, please click here

Contacts:
Media Contact:
Jordan Reese

215-573-6604

Copyright © University of Pennsylvania

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Synthetic Biology

New tool could help reshape the limits of synthetic biology: The 'telomerator' reshapes synthetic yeast chromosome into more flexible, realistic form, redefining what geneticists can build November 3rd, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Smallest world record has 'endless possibilities' for bio-nanotechnology October 8th, 2014

Artificial Cells Act Like the Real Thing: Cell-like compartments produce proteins and communicate with one another, similar to natural biological systems August 18th, 2014

Govt.-Legislation/Regulation/Funding/Policy

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Scientists 'bend' elastic waves with new metamaterials that could have commercial applications: Materials could benefit imaging and military enhancements such as elastic cloaking January 23rd, 2015

Harper Government Supports Research Innovation in Western Canada January 22nd, 2015

EnvisioNano: An image contest hosted by the National Nanotechnology Initiative (NNI) January 22nd, 2015

Possible Futures

Nanotechnology in Energy Applications Market Research Report 2014-2018: Radiant Insights, Inc January 15th, 2015

'Mind the gap' between atomically thin materials December 23rd, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Researchers discern the shapes of high-order Brownian motions November 17th, 2014

Academic/Education

Rice's Naomi Halas to direct Smalley Institute: Optics pioneer will lead Rice's multidisciplinary science institute January 15th, 2015

SUNY Board Appoints Dr. Alain Kaloyeros as Founding President of SUNY Polytechnic Institute January 13th, 2015

CNSE's Smart System Technology & Commercialization Center Successfully Recertifies as ISO 9001:2008 January 12th, 2015

SUNY Poly Now Accepting Applications to the Colleges of Nanoscale Science and Engineering for Fall 2015: Full Scholarships Available to Incoming CNSE Students January 7th, 2015

Self Assembly

Revealed: How bacteria drill into our cells and kill them December 2nd, 2014

Live Images from the Nano-cosmos: Researchers watch layers of football molecules grow November 5th, 2014

Outsmarting Thermodynamics in Self-assembly of Nanostructures: Berkeley Lab reports method for symmetry-breaking in feedback-driven self-assembly of optical metamaterials November 4th, 2014

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Nanomedicine

Teijin to Participate in Nano Tech 2015 January 22nd, 2015

2nd International Conference on Infectious Diseases & Nanomedicine (December 15-18, 2015, Kathmandu, NEPAL) January 22nd, 2015

Anti-microbial coatings with a long-term effect for surfaces – presentation at nano tech 2015 in Japan January 21st, 2015

A spoonful of sugar in silver nanoparticles to regulate their toxicity January 21st, 2015

Announcements

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Personal Care

Sunblock poses potential hazard to sea life August 20th, 2014

AQUANOVA receives Technology Leadership Award 2014 FROST & SULLIVAN honors NovaSOL® Technology again August 12th, 2014

Nanotechnology used in sunscreens: a Mexican achievement May 14th, 2014

Production of Nanocapsule from Sea-Buckthorn Extract in Iran May 3rd, 2014

Safety-Nanoparticles/Risk management

A spoonful of sugar in silver nanoparticles to regulate their toxicity January 21st, 2015

Nutrition, Safety Key To Consumer Acceptance of Nanotech, Genetic Modification In Foods December 2nd, 2014

Sustainable Nanotechnologies Project November 20th, 2014

A gut reaction November 19th, 2014

Nanobiotechnology

DNA 'glue' could someday be used to build tissues, organs January 14th, 2015

Photonic crystal nanolaser biosensor simplifies DNA detection: New device offers a simpler and potentially less expensive way to detect DNA and other biomolecules through changes in surface charge density or solution pH January 13th, 2015

Determination of Critical Force, Time for Manipulation of Biological Nanoparticles January 7th, 2015

DNA Origami Could Lead to Nano “Transformers” for Biomedical Applications: Tiny hinges and pistons hint at possible complexity of future nano-robots January 5th, 2015

Research partnerships

Wearable sensor clears path to long-term EKG, EMG monitoring January 20th, 2015

Graphene enables all-electrical control of energy flow from light emitters: First signatures of graphene plasmons at telecommunications wavelength revealed January 20th, 2015

Charge instability detected across all types of copper-based superconductors: Findings may help researchers synthesize materials that can superconduct at room temperature January 16th, 2015

Gold nanoparticles show promise for early detection of heart attacks: NYU School of Engineering Professors collaborate with researchers from Peking University on a new test strip January 15th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE