Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Leiden University uses NanoSight Characterization System to Aid Their Drug Delivery Research Programs

Professor Wim Jiskoot with Andrea Hawe and Vasco Filipe at Leiden University discuss results from the NanoSight LM20 system.
Professor Wim Jiskoot with Andrea Hawe and Vasco Filipe at Leiden University discuss results from the NanoSight LM20 system.

Abstract:
The Division of Drug Delivery Technology is part of the Leiden/Amsterdam Center for Drug Research (LACDR), a research institute located at the Gorlaeus laboratories in Leiden in the Netherlands. The group focuses primarily on vaccine delivery and on protein formulation and characterization with respect to immunogenicity. Nanoparticle size and count is vital to these research activities and the Division has selected the NanoSight LM20 to aid their programs.

Leiden University uses NanoSight Characterization System to Aid Their Drug Delivery Research Programs

Salisbury, UK | Posted on February 23rd, 2010

The leader of the team is Professor Wim Jiskoot. He describes what is important for his research: "The vaccine delivery group aims to develop innovative delivery systems, such as polymeric nanoparticles and liposomes, for the delivery of different types of vaccines through the conventional (injection) or needle-free administration routes (such as transcutaneous or intranasal delivery). It is very important to know the size of the delivery systems as the size can influence the uptake by the cells of the immune system, the diffusion through the skin, the release of vaccine components, and thus the immune response."

The protein characterization group seeks to understand the causes of unwanted immunogenicity of therapeutic proteins and develop transgenic mouse models capable of predicting immunogenicity of human/humanized proteins in a preclinical setting. Professor Jiskoot continues: "For the protein group, a good size characterization of protein aggregates is essential to better understand which size class is responsible for triggering unwanted immunogenicity of therapeutic proteins which is believed to be related to the presence of aggregates in the protein formulations. The group aims to stress and thoroughly characterize protein formulations to then test which ones are more immunogenic after their injection in the mouse models."

Prior to using NanoSight's LM20 system, the group used a variety of established particle characterization techniques such as Dynamic Light Scattering (DLS), Light Obscuration Particle Counting (LOPC) and Electron Microscopy (EM). However, each has deficiencies in terms of parameters such as sample preparation and speed of use. The main user is Vasco Filipe and he has seen several benefits which make the NanoSight his system of preference. "We are able to visualize the sample which gives us confidence in our results. Individual particle tracking enables a much better peak resolution than DLS so making it better suited to study polydispersed samples. It gives an approximate particle concentration while letting us see bacterial contamination easily as "swimming" particles."

To learn more about nanoparticle characterization using Nanoparticle Tracking Analysis (NTA), please visit the company's website (www.nanosight.com) and register for the latest issue of NanoTrail, the company's electronic newsletter.

####

About NanoSight
NanoSight Ltd, of Salisbury, UK, is the world leading provider of instruments for the optical detection and real time analysis of sub-micron particles. The Company supplies unique instruments for nanoparticle analysis in the sub-micron region that go far beyond existing light scattering techniques in the characterization of polydispersed systems. NanoSight delivers direct visualization of individual nanoscale particles in suspension from which independent quantitative estimation of particle size, size distribution and concentration are immediately obtained. In viral titer assessment, NanoSight produces more accurate concentration results than plaque assay, and delivers them within minutes, validating the results with a unique real-time image. Founded in 2004, the company currently has more than 200 systems in service worldwide, having begun commercial sales in 2006. The Company has a growing base of users worldwide, including BASF, BP GlaxoSmithKline, Novartis, 3M Corp, Roche, Solvay & Unilever and many universities. For more information, visit www.nanosight.com.

For more information, please click here

Contacts:

+44(0)1980 676060

Jezz Leckenby
+44 (0) 1799 521881

Copyright © NanoSight

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

TCL Unveils First 65” TV Featuring QD Vision’s Color IQ™ Quantum Dot Technology: Emerging industry leader introduces expanded quantum dot TV lineup May 30th, 2015

Nanotech Secures Additional Patents in Advanced Security Features: New patented features gain attention from the banknote industry May 30th, 2015

New 'designer carbon' from Stanford boosts battery performance May 30th, 2015

Two UCSB Professors Receive Early Career Research Awards: The Department of Energy’s award for young scientists acknowledges UC Santa Barbara’s standing as a top tier research institution May 29th, 2015

Academic/Education

SUNY Poly CNSE and NIOSH Launch Federal Nano Health and Safety Consortium: May 20th, 2015

New JEOL E-Beam Lithography System to Enhance Quantum NanoFab Capabilities May 6th, 2015

FEI Partners With the George Washington University to Equip New Science & Engineering Hall: Suite of new high-performance microscopes will be used for cutting-edge experiments at GW’s new research facility April 29th, 2015

Renishaw Raman systems used to study 2D materials at Boston University, Massachusetts, USA. April 28th, 2015

Nanomedicine

New chip makes testing for antibiotic-resistant bacteria faster, easier: Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time May 28th, 2015

New electronic stent could provide feedback and therapy — then dissolve May 27th, 2015

Arrowhead to Present at Jefferies 2015 Healthcare Conference May 27th, 2015

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Announcements

TCL Unveils First 65” TV Featuring QD Vision’s Color IQ™ Quantum Dot Technology: Emerging industry leader introduces expanded quantum dot TV lineup May 30th, 2015

Nanotech Secures Additional Patents in Advanced Security Features: New patented features gain attention from the banknote industry May 30th, 2015

New 'designer carbon' from Stanford boosts battery performance May 30th, 2015

Two UCSB Professors Receive Early Career Research Awards: The Department of Energy’s award for young scientists acknowledges UC Santa Barbara’s standing as a top tier research institution May 29th, 2015

Tools

Two UCSB Professors Receive Early Career Research Awards: The Department of Energy’s award for young scientists acknowledges UC Santa Barbara’s standing as a top tier research institution May 29th, 2015

Seeing the action: UCSB researchers develop a novel device to image the minute forces and actions involved in cell membrane hemifusion May 27th, 2015

Physicists solve quantum tunneling mystery: ANU media release: An international team of scientists studying ultrafast physics have solved a mystery of quantum mechanics, and found that quantum tunneling is an instantaneous process May 27th, 2015

This Slinky lookalike 'hyperlens' helps us see tiny objects: The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists' ability to observe single molecules May 23rd, 2015

Nanobiotechnology

New technique speeds nanoMRI imaging: Multiplexing technique for nanoscale magnetic resonance imaging developed by researchers in Switzerland cuts normal scan time from two weeks to two days May 28th, 2015

Seeing the action: UCSB researchers develop a novel device to image the minute forces and actions involved in cell membrane hemifusion May 27th, 2015

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Who needs water to assemble DNA? Non-aqueous solvent supports DNA nanotechnology May 27th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project