Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Researcher works toward making biological imaging 1,000 times faster with stimulus grant

Warren Zipfel
Warren Zipfel

Abstract:
Fluorescence lifetime imaging is a useful but relatively complex technique for probing the local microenvironment of a fluorescent molecule. The method can be used to help determine biochemical makeup of body tissues or measure distances between molecules on the nanometer scale.

With a new grant of more than $675,000 from the National Science Foundation funded by the American Reinvestment and Recovery Act (ARRA), Warren Zipfel '87, Ph.D. '93, associate professor of biomedical engineering, is working to make fluorescence lifetime imaging more efficient and simpler to implement.

Researcher works toward making biological imaging 1,000 times faster with stimulus grant

Ithaca, NY | Posted on November 17th, 2009

"I hope this will become a common mode of fluorescence imaging," Zipfel said.

The technique works by using fluorescent dyes to tag biological molecules of interest. These fluorophores absorb light from a pulsed laser, which puts them into a higher energy state, after which they emit light of a different wavelength. By measuring the "fluorescence lifetime" -- the time between the absorption of the light and the emission of the fluorescence -- scientists can gain information about the local environment the molecule resides in.

Fluorescence lifetime is commonly measured by time-correlated single photon counting (TCSPC), a method that, Zipfel says, "although is highly accurate, can be too slow for practical fluorescence imaging use."

With the new method and instrument his group is developing, Zipfel predicts that he will be able to collect images as much as 1,000 times faster than with TCSPC.

Zipfel also hopes that this new method will be useful to image the oxygen concentrations in and around tumors by using the method to image the phosphoresce lifetimes of oxygen sensitive phosphors. "Combined with confocal or multiphoton microscopy this would enable 3-D oxygen imaging in living animals -- something many researchers would find very useful," Zipfel said.

His group has already purchased a microscope and an optical bench with the new funding, and the grant will fund two of his graduate students for three years.

To date, Cornell has received 124 ARRA grants, totaling more than $99.9 million.

Graduate student Melissa Rice is a writer intern at the Cornell Chronicle.

####

About Cornell University
Once called "the first American university" by educational historian Frederick Rudolph, Cornell University represents a distinctive mix of eminent scholarship and democratic ideals. Adding practical subjects to the classics and admitting qualified students regardless of nationality, race, social circumstance, gender, or religion was quite a departure when Cornell was founded in 1865.

Today's Cornell reflects this heritage of egalitarian excellence. It is home to the nation's first colleges devoted to hotel administration, industrial and labor relations, and veterinary medicine. Both a private university and the land-grant institution of New York State, Cornell University is the most educationally diverse member of the Ivy League.

For more information, please click here

Contacts:
Media Contact:
Blaine Friedlander
(607) 254-8093

Cornell Chronicle:
Susan Lang
(607) 255-3613

Copyright © Cornell University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

A toolkit for transformable materials: How to design materials with reprogrammable shape and function January 20th, 2017

Explaining how 2-D materials break at the atomic level January 20th, 2017

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Govt.-Legislation/Regulation/Funding/Policy

A toolkit for transformable materials: How to design materials with reprogrammable shape and function January 20th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Strength of hair inspires new materials for body armor January 18th, 2017

Self-assembling particles brighten future of LED lighting January 18th, 2017

Nanomedicine

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Announcements

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

A toolkit for transformable materials: How to design materials with reprogrammable shape and function January 20th, 2017

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Ultra-precise chip-scale sensor detects unprecedentedly small changes at the nanoscale January 20th, 2017

Tools

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Distinguishing truth under the surface: electrostatic or mechanic December 31st, 2016

Nanomechanics Inc. Continues Growth in Revenue and Market Penetration: Leading nanoindentation company reports continued growth in revenues and distribution channels on national and international scales December 27th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Nanoscale view of energy storage January 16th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

Nanobiotechnology

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project