Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Researcher works toward making biological imaging 1,000 times faster with stimulus grant

Warren Zipfel
Warren Zipfel

Abstract:
Fluorescence lifetime imaging is a useful but relatively complex technique for probing the local microenvironment of a fluorescent molecule. The method can be used to help determine biochemical makeup of body tissues or measure distances between molecules on the nanometer scale.

With a new grant of more than $675,000 from the National Science Foundation funded by the American Reinvestment and Recovery Act (ARRA), Warren Zipfel '87, Ph.D. '93, associate professor of biomedical engineering, is working to make fluorescence lifetime imaging more efficient and simpler to implement.

Researcher works toward making biological imaging 1,000 times faster with stimulus grant

Ithaca, NY | Posted on November 17th, 2009

"I hope this will become a common mode of fluorescence imaging," Zipfel said.

The technique works by using fluorescent dyes to tag biological molecules of interest. These fluorophores absorb light from a pulsed laser, which puts them into a higher energy state, after which they emit light of a different wavelength. By measuring the "fluorescence lifetime" -- the time between the absorption of the light and the emission of the fluorescence -- scientists can gain information about the local environment the molecule resides in.

Fluorescence lifetime is commonly measured by time-correlated single photon counting (TCSPC), a method that, Zipfel says, "although is highly accurate, can be too slow for practical fluorescence imaging use."

With the new method and instrument his group is developing, Zipfel predicts that he will be able to collect images as much as 1,000 times faster than with TCSPC.

Zipfel also hopes that this new method will be useful to image the oxygen concentrations in and around tumors by using the method to image the phosphoresce lifetimes of oxygen sensitive phosphors. "Combined with confocal or multiphoton microscopy this would enable 3-D oxygen imaging in living animals -- something many researchers would find very useful," Zipfel said.

His group has already purchased a microscope and an optical bench with the new funding, and the grant will fund two of his graduate students for three years.

To date, Cornell has received 124 ARRA grants, totaling more than $99.9 million.

Graduate student Melissa Rice is a writer intern at the Cornell Chronicle.

####

About Cornell University
Once called "the first American university" by educational historian Frederick Rudolph, Cornell University represents a distinctive mix of eminent scholarship and democratic ideals. Adding practical subjects to the classics and admitting qualified students regardless of nationality, race, social circumstance, gender, or religion was quite a departure when Cornell was founded in 1865.

Today's Cornell reflects this heritage of egalitarian excellence. It is home to the nation's first colleges devoted to hotel administration, industrial and labor relations, and veterinary medicine. Both a private university and the land-grant institution of New York State, Cornell University is the most educationally diverse member of the Ivy League.

For more information, please click here

Contacts:
Media Contact:
Blaine Friedlander
(607) 254-8093

Cornell Chronicle:
Susan Lang
(607) 255-3613

Copyright © Cornell University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Synthesized microporous 3-D graphene-like carbons: IBS research team create carbon synthesis using zeolites as a template July 1st, 2016

A drop of water as a model for the interplay of adhesion and stiction June 30th, 2016

No need in supercomputers: Russian scientists suggest a PC to solve complex problems tens of times faster than with massive supercomputers June 30th, 2016

Surprising qualities of insulator ring surfaces: Surface phenomena in ring-shaped topological insulators are just as controllable as those in spheres made of the same material June 30th, 2016

Govt.-Legislation/Regulation/Funding/Policy

A drop of water as a model for the interplay of adhesion and stiction June 30th, 2016

How cancer cells spread and squeeze through tiny blood vessels (video) June 30th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Ultrathin, flat lens resolves chirality and color: Multifunctional lens could replace bulky, expensive machines June 25th, 2016

Nanomedicine

A drop of water as a model for the interplay of adhesion and stiction June 30th, 2016

How cancer cells spread and squeeze through tiny blood vessels (video) June 30th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Announcements

Synthesized microporous 3-D graphene-like carbons: IBS research team create carbon synthesis using zeolites as a template July 1st, 2016

A drop of water as a model for the interplay of adhesion and stiction June 30th, 2016

No need in supercomputers: Russian scientists suggest a PC to solve complex problems tens of times faster than with massive supercomputers June 30th, 2016

Surprising qualities of insulator ring surfaces: Surface phenomena in ring-shaped topological insulators are just as controllable as those in spheres made of the same material June 30th, 2016

Tools

How cancer cells spread and squeeze through tiny blood vessels (video) June 30th, 2016

Oxford Instruments and Dresden High Magnetic Field Laboratory collaborate to develop HTS magnet technology components for high field superconducting magnet systems June 29th, 2016

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

FEI Launches Helios G4 DualBeam Series for Materials Science: The Helios G4 DualBeam Series features new capabilities to enable scientists and engineers to answer the most demanding and challenging scientific questions June 27th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

How cancer cells spread and squeeze through tiny blood vessels (video) June 30th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Ultrathin, flat lens resolves chirality and color: Multifunctional lens could replace bulky, expensive machines June 25th, 2016

Particle zoo in a quantum computer: First experimental quantum simulation of particle physics phenomena June 23rd, 2016

Nanobiotechnology

A drop of water as a model for the interplay of adhesion and stiction June 30th, 2016

How cancer cells spread and squeeze through tiny blood vessels (video) June 30th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic