Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Researcher works toward making biological imaging 1,000 times faster with stimulus grant

Warren Zipfel
Warren Zipfel

Abstract:
Fluorescence lifetime imaging is a useful but relatively complex technique for probing the local microenvironment of a fluorescent molecule. The method can be used to help determine biochemical makeup of body tissues or measure distances between molecules on the nanometer scale.

With a new grant of more than $675,000 from the National Science Foundation funded by the American Reinvestment and Recovery Act (ARRA), Warren Zipfel '87, Ph.D. '93, associate professor of biomedical engineering, is working to make fluorescence lifetime imaging more efficient and simpler to implement.

Researcher works toward making biological imaging 1,000 times faster with stimulus grant

Ithaca, NY | Posted on November 17th, 2009

"I hope this will become a common mode of fluorescence imaging," Zipfel said.

The technique works by using fluorescent dyes to tag biological molecules of interest. These fluorophores absorb light from a pulsed laser, which puts them into a higher energy state, after which they emit light of a different wavelength. By measuring the "fluorescence lifetime" -- the time between the absorption of the light and the emission of the fluorescence -- scientists can gain information about the local environment the molecule resides in.

Fluorescence lifetime is commonly measured by time-correlated single photon counting (TCSPC), a method that, Zipfel says, "although is highly accurate, can be too slow for practical fluorescence imaging use."

With the new method and instrument his group is developing, Zipfel predicts that he will be able to collect images as much as 1,000 times faster than with TCSPC.

Zipfel also hopes that this new method will be useful to image the oxygen concentrations in and around tumors by using the method to image the phosphoresce lifetimes of oxygen sensitive phosphors. "Combined with confocal or multiphoton microscopy this would enable 3-D oxygen imaging in living animals -- something many researchers would find very useful," Zipfel said.

His group has already purchased a microscope and an optical bench with the new funding, and the grant will fund two of his graduate students for three years.

To date, Cornell has received 124 ARRA grants, totaling more than $99.9 million.

Graduate student Melissa Rice is a writer intern at the Cornell Chronicle.

####

About Cornell University
Once called "the first American university" by educational historian Frederick Rudolph, Cornell University represents a distinctive mix of eminent scholarship and democratic ideals. Adding practical subjects to the classics and admitting qualified students regardless of nationality, race, social circumstance, gender, or religion was quite a departure when Cornell was founded in 1865.

Today's Cornell reflects this heritage of egalitarian excellence. It is home to the nation's first colleges devoted to hotel administration, industrial and labor relations, and veterinary medicine. Both a private university and the land-grant institution of New York State, Cornell University is the most educationally diverse member of the Ivy League.

For more information, please click here

Contacts:
Media Contact:
Blaine Friedlander
(607) 254-8093

Cornell Chronicle:
Susan Lang
(607) 255-3613

Copyright © Cornell University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

Progress made in developing nanoscale electronics: New research directs charges through single molecules April 21st, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Nanomedicine

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

Amino-functionalized carbon nanotubes act as a carrier for nerve growth factor April 21st, 2014

Newly-Produced Bone Cement Able to Carry Medicine April 21st, 2014

Announcements

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Tools

MRI, on a molecular scale: Researchers develop system that could one day peer into the atomic structure of individual molecules April 20th, 2014

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

Aerotech X-Y ball-screw stage for economical high performance Planar positioning April 16th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Energy Research Facility Construction Project at Brookhaven Lab Wins U.S. Energy Secretary's Achievement Award April 16th, 2014

IDTechEx Printed Electronics Europe 2014 Award Winners April 1st, 2014

Dais Analytic Wins SBIR Grant: Dais Analytic Receives US Army Small Business Innovation Research Grant to Further Its Demonstrated Successes in Cleaning Most Forms of Wastewater March 28th, 2014

Nanobiotechnology

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Targeting cancer with a triple threat: MIT chemists design nanoparticles that can deliver three cancer drugs at a time April 15th, 2014

Biologists Develop Nanosensors to Visualize Movements and Distribution of Plant Stress Hormone April 15th, 2014

In latest generation of tiny biosensors, size isn't everything: UCLA researchers overturn conventional wisdom on nanowire-based diagnostic devices April 11th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE