Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Keio University’s Dr. Suda Selects Fluidigm BioMark™ System for Single Stem Cell Research: Single Cell Study Holds the Key to Hematopoietic Stem Cell Progress

Abstract:
Fluidigm Corporation today announced that Dr. Toshio Suda of Keio University's 21st Century Center of Excellence (COE) Program, Graduate School of Medicine, has selected the BioMark™ System for Genetic Analysis to assist their research of mouse hematopoietic single stem cells.

Keio University’s Dr. Suda Selects Fluidigm BioMark™ System for Single Stem Cell Research: Single Cell Study Holds the Key to Hematopoietic Stem Cell Progress

SOUTH SAN FRANCISCO, CA | Posted on June 23rd, 2009

Keio University's COE is using the unique microfluidic properties of the Fluidigm's integrated fluidic circuits (IFCs) to analyze selected genes in hematopoietic stem cells (HSCs). The interaction of HSCs with their particular microenvironment, known as the stem cell niche, is critical for adult hematopoiesis in bone marrow. The COE plans to use both Fluidigm's Dynamic Array™ and Digital Array™ IFCs in this effort.

Keio University's COE Graduate School of Medicine Program brings together researchers and clinicians from stem cell biology, regenerative medicine, immunology, autoimmune disease and infectious disease areas to form a scientific community that conducts basic medical research, utilizing the elucidation of the pathology of intractable diseases and unique disease model systems to develop new methods of treatment.

"Dr. Suda's work in modeling the differentiation of stem cells and purification methods for hematopoietic stem cells is remarkable. We hope Fluidigm's technology and its ability to provide extreme sensitivity at the single-cell level can help him unlock new vistas of understanding as Dr. Suda explores hematopoietic stem cells and their niches," said Gajus Worthington, president and chief executive officer of Fluidigm.

"Our research in hematopoietic stem cells and how they interact with their niches to maintain a balance between self-renewal and differentiation is key to ultimately establishing techniques for niche-based therapy. The Fluidigm BioMark technology enables us to easily study populations of HSCs on the single cell level allowing us to accurately characterize the cellular and molecular components of ‘Niche complex'," said Dr. Suda.

The ability of Fluidigm's microfluidic devices - called integrated fluidic circuits (IFCs) -- to isolate and control individual molecules provides great insight into the development of biological events that influence stem cell differentiation. Analyzing the stochastic differences between individual cells typically requires studying large numbers of individual cells and genes. Fluidigm's IFC volume requirements are so low that researchers have been able to study as many as 1,000 genes from an individual cell. The technology facilitates thousands of single cell experiments allowing the biological differences to manifest themselves.

A recent Nature Reports Stem Cells article noted: "Stem cells are defined by their remarkable ability to self-renew and differentiate into specialized cells. But even after careful sorting, a single population of stem cells is dynamic: some divide rapidly and others more slowly; some differentiate, others self-renew; some can give rise to more lineages than others. Because of this variation, population studies of stem cells are unable to accurately address essential questions, such as defining discrete steps from a single stem cell to a complex population of cells."

"Each stem cell needs to be treated as an individual because it's not necessarily in the same state at every point in time. You have to look at them as individuals," noted Worthington.

The complete Nature article is available at: www.nature.com/stemcells/2009/0905/090507/full/stemcells.2009.71.html

####

About Fluidigm Corporation
Fluidigm develops, manufactures and markets proprietary Integrated Fluidic Circuit (IFC) systems that significantly improve productivity in life science research. Fluidigm’s IFCs enable the simultaneous performance of thousands of sophisticated biochemical measurements in extremely minute volumes. These “integrated circuits for biology” are made possible by miniaturizing and integrating liquid handling components on a single microfabricated microfluidic device. Fluidigm’s IFC systems, consisting of instrumentation, software and single-use IFCs, increase throughput, decrease costs and enhance sensitivity compared to conventional laboratory systems. Fluidigm products have not been cleared or approved by the Food and Drug Administration for use as a diagnostic and are only available for research use.

Fluidigm, the Fluidigm logo, Topaz, BioMark, Dynamic Array, Digital Array, Access Array and NanoFlex are trademarks of Fluidigm Corporation.

For more information, please click here

Contacts:
Fluidigm Corp.
Howard High
650-266-6081 (office)
510-786-7378 (mobile)

Copyright © Business Wire 2009

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Leti Presents Advances in Propagation Modeling and Antenna Design for mmWave Spectrum: Paper Is One of 15 that Leti Presented at European Conference on Antennas and Propagation March 19-24 March 23rd, 2017

Rice U. refines filters for greener natural gas: New study defines best materials for carbon capture, methane selectivity March 23rd, 2017

Nanomedicine

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Block copolymer micellization as a protection strategy for DNA origami March 17th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

Announcements

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Rice U. refines filters for greener natural gas: New study defines best materials for carbon capture, methane selectivity March 23rd, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

Tools

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

CRMGroup in Belgium uses a Deben three point bending stage in the development of new steel & coated steel products for automotive and other industrial applications March 21st, 2017

Next-gen steel under the microscope March 18th, 2017

Novel nozzle saves crystals: Double flow concept widens spectrum for protein crystallography March 17th, 2017

New-Contracts/Sales/Customers

JPK selects compact tensile stage from Deben for their NanoWizard® AFM platform to broaden capabilities for materials characterisation February 22nd, 2017

Cetim Facility Receives Bruker Contour CMM Dimensional Analysis System: New Optical Coordinate Measurement Technology Enables High-Precision 3D Scanning November 16th, 2016

Industrial Nanotech, Inc. Announces Plans to Spin Off New Product Line to Major Paint Compan November 9th, 2016

Leti Provides New Low-noise Image Technology to French SME PYXALIS; Will Be Demonstrated at Vision 2016 in Stuttgart November 3rd, 2016

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project