Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > New Tool Gives Researchers a Glimpse of Biomolecules in Motion

NIST researcher Ted Heilweil, National Research Council postdoctoral fellow Catherine Cooksey (pictured), and NIST Summer Undergraduate Research Fellow Ben Greer from Carnegie Mellon University have demonstrated the feasibility of a new technique for studying biomolecules using terahertz radiation. Because terahertz waves are almost completely absorbed by water, the team was able to reduce the amount of water to the bare minimum while still providing a realistic sample environment by using hollow, nanosized droplets called micelles as tiny test tubes.

Credit: NIST
NIST researcher Ted Heilweil, National Research Council postdoctoral fellow Catherine Cooksey (pictured), and NIST Summer Undergraduate Research Fellow Ben Greer from Carnegie Mellon University have demonstrated the feasibility of a new technique for studying biomolecules using terahertz radiation. Because terahertz waves are almost completely absorbed by water, the team was able to reduce the amount of water to the bare minimum while still providing a realistic sample environment by using hollow, nanosized droplets called micelles as tiny test tubes.

Credit: NIST

Abstract:
The ability of biomolecules to flex and bend is important for the performance of many functions within living cells. However, researchers interested in how biomolecules such as amino acids and proteins function have long had to make inferences from a series of X-ray-like "still pictures" of pure crystalline samples. Now, using a new technique based on terahertz (THz) spectroscopy, scientists at the National Institute of Standards and Technology (NIST) have recently taken the first step toward revealing the hidden machinations of biomolecules in water.*

New Tool Gives Researchers a Glimpse of Biomolecules in Motion

GAITHERSBURG, MD | Posted on January 13th, 2009

With wavelengths that range from 1 millimeter to 25 micrometers, terahertz radiation falls between the infrared and microwave spectral regions. Researchers can determine how molecules are moving by passing terahertz radiation through a sample and measuring which wavelengths are absorbed. Unfortunately, room temperature water, the medium in which biological molecules typically are studied, absorbs nearly all of the terahertz radiation, limiting the utility of terahertz spectroscopy for probing biomolecular function.

To avoid the water problem, the NIST team needed to find a way to provide a simple but realistic environment for the biomolecules that contained the least amount of water possible. NIST researcher Ted Heilweil, National Research Council postdoctoral fellow Catherine Cooksey and NIST Summer Undergraduate Research Fellow Ben Greer from Carnegie Mellon University found their solution in the form of nanoscale droplets made of soap-like molecules called micelles.

Using the micelles as tiny test tubes, the team filled the hollow molecules with a small sample of water and the amino acid L-proline, a protein building block. Measurements validated their hypothesis that the micelles would provide an aqueous environment that allows the amino acid to flex and bend while limiting the absorption of the terahertz radiation by water. The terahertz measurements on this simple biomolecule compared well with expectations from other studies, further validating the technique.

According to Heilweil, this study is an important first step toward using terahertz radiation for studying biomolecules. More ambitious measurements on larger molecules such as small peptides, proteins, and DNA fragments will be more challenging, but he says it may be possible in the near future.

"If we can get larger molecules in [the micelles], we can get a much better idea of how living molecules function," Heilweil said. "This will let us see the basic, most fundamental building blocks of life as they move, which is very exciting."

* C. Cooksey, B. J. Greer and E. J. Heilweil. Terahertz spectroscopy of l-proline in reverse aqueous micelles. Chemical Physics Letters. Available online Nov. 21, 2008.

####

About NIST
Founded in 1901, NIST is a non-regulatory federal agency within the U.S. Department of Commerce. NIST's mission is to promote U.S. innovation and industrial competitiveness by advancing measurement science, standards, and technology in ways that enhance economic security and improve our quality of life.

For more information, please click here

Contacts:
Mark Esser

(301) 975-8735

Copyright © NIST

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

"Terahertz spectroscopy of l-proline in reverse aqueous micelles." Chemical Physics Letters

Related News Press

News and information

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Discoveries

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Tools

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

National Synchrotron Light Source II Achieves 'First Light' October 23rd, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE