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February 26th, 2007

Quantum Rods and Dots Image Cancer Cells

Abstract:
Brightly fluorescent quantum dots and quantum rods are quickly becoming important tools for identifying specific molecules and cells in living systems. Two new reports demonstrate some of the ways in which cancer researchers are using these nanoscale imaging agents.

Hideo Higuchi, Ph.D., and colleagues at Tohoku University in Japan, used antibody-labeled quantum dots and a high-sensitivity fluorescence microscope fitted with a video camera to make 30-frame-per-second movies of these nanoparticles as they traveled through the bloodstream to tumors in mice. In a paper published in the journal Cancer Research, the investigators identified six distinct steps in the process by which quantum dots labeled with the HER2 monoclonal antibody travel from the site of injection to the space surrounding the cell nucleus. The HER2 monoclonal antibody binds to a protein found on the surface of certain breast and other tumors.

Source:
nano.cancer.gov

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