Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Delivery systems of plasmid DNA and messenger RNA for advanced therapies

Abstract:
Innovation Center of NanoMedicine (Center Director: Prof. Kazunori Kataoka) has announced that Prof. Satoshi Uchida (Principal Research Scientist), who is also Associated Professor of the Kyoto Prefectural University of Medicine, published an article review about non-viral messenger RNA (mRNA) and plasmid DNA (pDNA) delivery by addressing the various delivery technologies of mRNA and pDNA, from basic research to therapeutic and clinical application; Pharmaceutics 2022, 14(4), 810.

Delivery systems of plasmid DNA and messenger RNA for advanced therapies

Kawasaki, Japan | Posted on April 15th, 2022

The vast potential of non-viral delivery systems of mRNA and pDNA has been demonstrated in the vaccines against coronavirus disease 2019 (COVID-19). Indeed, two formulations of mRNA vaccines from Pfizer–BioNTech and Moderna were approved for emergency use within one year after the pandemic outbreak, and have been administered to billions of people worldwide. Furthermore, a pDNA vaccine developed by Zydus Cadila also obtained emergency approval in India, exhibiting high efficiency for preventing infection in a large clinical trial. These successful examples prompt further research and the development of vaccines and therapeutics based on mRNA and pDNA. The target areas are not limited to preventive vaccination for infectious diseases but expand to therapeutic cancer vaccines, genome editing, and protein replacement therapy.

However, current non-viral systems need improvement. For example, the relatively intense adverse effects of mRNA vaccines, including myocarditis, provoke vaccine hesitancy and debates about repeated boosting. Thus, safer formulations are in demand for mRNA vaccines to become platforms for various infectious diseases. Meanwhile, therapeutic cancer vaccines require more efficient formulations to overcome the immunosuppressive nature of cancers. For other applications, including genome editing and protein replacement therapy, delivery carriers should reach specific tissues and introduce pDNA and mRNA without damaging the tissues. The present Special Issue addresses vigorous efforts to develop mRNA and pDNA delivery systems and apply them to disease treatment to meet these demands.

The development of non-viral delivery systems has two directions. One focuses on the general improvement of delivery processes, which includes preventing extracellular mRNA and pDNA degradation by nucleases, intracellular targeting of mRNA and pDNA to the desired sites, and prolonging the duration of protein expression from mRNA and pDNA. In the other direction, delivery systems are fine-tuned for specific purposes, such as reaching particular tissues and cells to achieve therapeutic goals and stimulating innate immune systems when used in vaccinations.

This paper provides comprehensive reviews of non-viral mRNA and pDNA delivery by addressing the various delivery technologies of mRNA and pDNA, from basic research to therapeutic and clinical application.

####

For more information, please click here

Contacts:
Makoto Shimazaki
Innovation Center of NanoMedicine

Office: 日本
Misato Yamamoto
Innovation Center of NanoMedicine

Copyright © Innovation Center of NanoMedicine

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

ARTICLE TITLE

Related News Press

News and information

Drawing data in nanometer scale September 30th, 2022

Researchers unveil mystery inside Li- o2 batteries September 30th, 2022

Synthesis of air-stable room-temperature van der Waals magnetic thin flakes September 30th, 2022

ACM Research Launches New Furnace Tool for Thermal Atomic Layer Deposition to Support Advanced Semiconductor Manufacturing Requirements: Ultra Fn A Furnace Tool Shipped to China-Based Foundry Customer September 30th, 2022

Possible Futures

Researchers unveil mystery inside Li- o2 batteries September 30th, 2022

Synthesis of air-stable room-temperature van der Waals magnetic thin flakes September 30th, 2022

Layer Hall effect and hidden Berry curvature in antiferromagnetic insulators September 30th, 2022

ACM Research Launches New Furnace Tool for Thermal Atomic Layer Deposition to Support Advanced Semiconductor Manufacturing Requirements: Ultra Fn A Furnace Tool Shipped to China-Based Foundry Customer September 30th, 2022

Nanomedicine

Cleveland researchers reveal new strategy to prevent blood clots without increasing the risk of bleeding: University Hospitals and Case Western Reserve University findings may be especially impactful for cancer patients who experience blood clot complications September 30th, 2022

Georgia State researchers discover novel way to treat IBD with lipid nanoparticles August 26th, 2022

Engineers fabricate a chip-free, wireless electronic “skin”: The device senses and wirelessly transmits signals related to pulse, sweat, and ultraviolet exposure, without bulky chips or batteries August 19th, 2022

Immune system: First image of antigen-bound T-cell receptor at atomic resolution: Antigen binding does not trigger any structural changes in T-cell receptors – Signal transduction probably occurs after receptor enrichment August 19th, 2022

Discoveries

Surface microstructures of lunar soil returned by Chang’e-5 mission reveal an intermediate stage in space weathering process September 30th, 2022

Researchers unveil mystery inside Li- o2 batteries September 30th, 2022

Synthesis of air-stable room-temperature van der Waals magnetic thin flakes September 30th, 2022

Layer Hall effect and hidden Berry curvature in antiferromagnetic insulators September 30th, 2022

Announcements

Researchers unveil mystery inside Li- o2 batteries September 30th, 2022

Synthesis of air-stable room-temperature van der Waals magnetic thin flakes September 30th, 2022

Layer Hall effect and hidden Berry curvature in antiferromagnetic insulators September 30th, 2022

ACM Research Launches New Furnace Tool for Thermal Atomic Layer Deposition to Support Advanced Semiconductor Manufacturing Requirements: Ultra Fn A Furnace Tool Shipped to China-Based Foundry Customer September 30th, 2022

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Conformal optical black hole for cavity September 30th, 2022

Cleveland researchers reveal new strategy to prevent blood clots without increasing the risk of bleeding: University Hospitals and Case Western Reserve University findings may be especially impactful for cancer patients who experience blood clot complications September 30th, 2022

Ultrasmall VN/Co heterostructure with optimized N active sites anchored in N-doped graphitic nanocarbons for boosting hydrogen evolution September 30th, 2022

Layer Hall effect and hidden Berry curvature in antiferromagnetic insulators September 30th, 2022

Nanobiotechnology

Cleveland researchers reveal new strategy to prevent blood clots without increasing the risk of bleeding: University Hospitals and Case Western Reserve University findings may be especially impactful for cancer patients who experience blood clot complications September 30th, 2022

Georgia State researchers discover novel way to treat IBD with lipid nanoparticles August 26th, 2022

Rice team eyes cells for sophisticated data storage: National Science Foundation backs effort to turn living cells into equivalent of computer RAM August 19th, 2022

Engineers fabricate a chip-free, wireless electronic “skin”: The device senses and wirelessly transmits signals related to pulse, sweat, and ultraviolet exposure, without bulky chips or batteries August 19th, 2022

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project