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Home > Press > Nanothermometry to improve anticancer strategies

Photothermal excitation of gold-based nanomaterials: the
nanoparticle absorbs NIR (near infrared) light resulting in a localized
heating. X-rays act as a probe of the local temperature.

Image credit: NanoLetteres
Photothermal excitation of gold-based nanomaterials: the nanoparticle absorbs NIR (near infrared) light resulting in a localized heating. X-rays act as a probe of the local temperature. Image credit: NanoLetteres

Abstract:
In hyperthermia treatments, the temperature is raised above
physiological levels to induce the death of cancerous cells. The *local
application of hyperthermia is key for a successful treatment* and to
reduce damage to the healthy surrounding tissues. Going down to the
nanoscale, nanoparticles can be used in hyperthermia treatments acting
as nanoheaters and triggering cellular damage and/or inducing drug
release in a selective manner.

Nanothermometry to improve anticancer strategies

Madrid, Spain | Posted on February 10th, 2021

The optimization of the heat capability of the nanoparticles is very
important to better adjust the therapeutic thermal onset, since, in some
cases, thermal healing effects may occurs though local heating without a
macroscopic temperature rise. Measuring the nanoscale details of the
heating in the surrounding of the nanoparticles is challenging; so far
indirect methods have been tested.

In their /Nano Letters /publication, a group of researchers led by Dr.
Ana Espinosa (IMDEA Nanociencia) and Álvaro Muñoz-Noval (UCM) have
proposed the measurement of the nanoscale heating of gold-based
nanoparticles under hyperthermia conditions using X-ray absorption
spectroscopy as an onsite and direct nanothermometric method. The
results reveal *significant nanothermal gradients*, it is, high
temperature variations within a small volume and evidence a nanoscopic
local temperature significantly higher than global temperature
measurements. This method is versatile and allows to measure the heating
at the nanoscale for all types of particles and systems under
hyperthermia exposure.

This work is an outcome of Dr. Ana Espinosa’s research group at IMDEA
Nanociencia and has been partially funded by the “Atracción de
Talento”//Grant from Comunidad de Madrid, the Spanish Association
Against Cancer (AECC), and the Severo Ochoa Excellence award to IMDEA
Nanociencia (2017-2021).

####

For more information, please click here

Contacts:
IMDEA Nanociencia
C/Faraday 9
28049 Madrid, Spain
Tel.: +34 91 299 87 00
www.nanociencia.imdea.org
Twitter: @IMDEA_Nano
Facebook: @IMDEANanociencia
Instagram: @IMDEANanociencia

Copyright © IMDEA Nanociencia

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