Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Dipanjan Pan demonstrates new method to produce gold nanoparticles in cancer cells: Possible applications in x-ray imaging, cancer treatment

Abstract:
Dipanjan Pan, professor of chemical, biochemical, and environmental engineering at UMBC, and collaborators published a seminal study in Nature Communications that demonstrates for the first time a method of biosynthesizing plasmonic gold nanoparticles within cancer cells, without the need for conventional bench-top lab methods. It has the potential to notably expand biomedical applications.

Dipanjan Pan demonstrates new method to produce gold nanoparticles in cancer cells: Possible applications in x-ray imaging, cancer treatment

Baltimore, MD | Posted on September 11th, 2020

Conventional laboratory-based synthesis of gold nanoparticles require ionic precursors and reducing agents subjected to varying reaction conditions such as temperature, pH, and time. This leads to variation in nanoparticle size, morphology and functionalities that are directly correlated to their internalization in cells, their residence time in vivo, and clearance. In order to avoid these uncertainties, this work demonstrates that biosynthesis of gold nanoparticles can be achieved efficiently and directly inside cancer cells without requiring conventional laboratory methods.

The researchers examined how various cancer cells responded to the introduction of chloroauric acid to their cellular microenvironment by forming gold nanoparticles. These nanoparticles generated within the cell can potentially be used for various biomedical applications, including in x-ray imaging and in therapy by destroying abnormal tissue or cells.

In the paper, Pan and his team describe their new method of producing these plasmonic gold nanoparticles within cells in minutes, within a cell's nucleus, using polyethylene glycol as a delivery vector for ionic gold. "We have developed a unique system where gold nanoparticles are reduced by cellular biomolecules and those are able to retain their functionality, including the capacity to guide the remaining cluster to the nucleus," says Pan.

They also worked to further demonstrate the biomedical potential of this approach by inducing in-situ biosynthesis of gold nanoparticles within a mouse tumor, followed by photothermal remediation of the tumor. Pan explains that the mouse study exemplified how "the intracellular formation and nuclear migration of these gold nanoparticles presents a highly promising approach for drug delivery application."

"Gold is the quintessential noble element that has been used in biomedical applications since its first colloidal synthesis more than three centuries ago," Pan notes. "To appreciate its potential for clinical application, however, the most challenging research ahead of us will be to find new methods of producing these particles with uncompromised reproducibility with functionalities that can promote efficient cellular binding, clearance, and biocompatibility and to assess their long-term term effects on human health. This new study is a small but important step toward that overarching goal."

###

In addition to his appointment at UMBC, Pan is a professor of diagnostic radiology and nuclear medicine and pediatrics at the University of Maryland School of Medicine (UMSOM) as part of his dual appointment with the University of Maryland, Baltimore. Coauthors on the paper are affiliated with the University of Illinois, Urbana-Champaign; UMSOM; and Cytoviva, Inc.

####

For more information, please click here

Contacts:
Megan Hanks Mastrola

410-455-5791

Copyright © University of Maryland

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

RELATED JOURNAL ARTICLE:

Related News Press

News and information

Nano-microscope gives first direct observation of the magnetic properties of 2D materials: Discovery means new class of materials and technologies September 18th, 2020

Physicists make electrical nanolasers even smaller September 18th, 2020

Shape matters for light-activated nanocatalysts - Study: Pointed tips on aluminum 'octopods' increase catalytic reactivity September 18th, 2020

Aberrant electronic and structural alterations in pressure tuned perovskite NaOsO3 September 18th, 2020

Cancer

Silver-plated gold nanostars detect early cancer biomarkers: New optical sensing platform can detect genomic cancer biomarkers directly in patient tissues July 24th, 2020

Wearable patch may provide new treatment option for skin cancer June 18th, 2020

Prodigiosin-based solution has selective activity against cancer cells: A new nanoformulation was described by Kazan University's Bionanotechnology Lab in Frontiers in Bioengineering and Biotechnology June 12th, 2020

First measurement of electron energy distributions, could enable sustainable energy technologies June 5th, 2020

Possible Futures

Nano-microscope gives first direct observation of the magnetic properties of 2D materials: Discovery means new class of materials and technologies September 18th, 2020

Physicists make electrical nanolasers even smaller September 18th, 2020

Shape matters for light-activated nanocatalysts - Study: Pointed tips on aluminum 'octopods' increase catalytic reactivity September 18th, 2020

Aberrant electronic and structural alterations in pressure tuned perovskite NaOsO3 September 18th, 2020

Nanomedicine

Arrowhead ARO-AAT Phase 2 Interim Results in Patients with Alpha-1 Liver Disease Demonstrate Improvements in Key Parameters after Six Months of Treatment September 16th, 2020

Gentle probes could enable massive brain data collection: National Institutes of Health backing Rice’s Chong Xie to refine flexible nanoelectronics thread September 14th, 2020

Understanding electron transport in graphene nanoribbons: New understanding of the electrical properties of graphene nanoribbons (GRBs), when bounded with aromatic molecules, could have significant benefits in the development of chemosensors and personalized medicine September 11th, 2020

Arrowhead Pharmaceuticals to Participate in Upcoming September 2020 Conferences September 10th, 2020

Announcements

Nano-microscope gives first direct observation of the magnetic properties of 2D materials: Discovery means new class of materials and technologies September 18th, 2020

Physicists make electrical nanolasers even smaller September 18th, 2020

Shape matters for light-activated nanocatalysts - Study: Pointed tips on aluminum 'octopods' increase catalytic reactivity September 18th, 2020

Aberrant electronic and structural alterations in pressure tuned perovskite NaOsO3 September 18th, 2020

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Who stole the light? Self-induced ultrafast demagnetization limits the amount of light diffracted from magnetic samples at soft x-ray energies September 18th, 2020

Nano-microscope gives first direct observation of the magnetic properties of 2D materials: Discovery means new class of materials and technologies September 18th, 2020

Physicists make electrical nanolasers even smaller September 18th, 2020

Shape matters for light-activated nanocatalysts - Study: Pointed tips on aluminum 'octopods' increase catalytic reactivity September 18th, 2020

Nanobiotechnology

Arrowhead ARO-AAT Phase 2 Interim Results in Patients with Alpha-1 Liver Disease Demonstrate Improvements in Key Parameters after Six Months of Treatment September 16th, 2020

Gentle probes could enable massive brain data collection: National Institutes of Health backing Rice’s Chong Xie to refine flexible nanoelectronics thread September 14th, 2020

Understanding electron transport in graphene nanoribbons: New understanding of the electrical properties of graphene nanoribbons (GRBs), when bounded with aromatic molecules, could have significant benefits in the development of chemosensors and personalized medicine September 11th, 2020

Arrowhead Pharmaceuticals to Participate in Upcoming September 2020 Conferences September 10th, 2020

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project