Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Damaged hearts rewired with nanotube fibers: Texas Heart doctors confirm Rice-made, conductive carbon threads are electrical bridges

(Credit: James Philpot/Texas Heart Institute)

The Texas Heart Institute (THI), founded by world-renowned cardiovascular surgeon Dr. Denton A. Cooley in 1962, is a nonprofit organization dedicated to reducing the devastating toll of cardiovascular disease through innovative and progressive programs in research, education and improved patient care. More information about THI (@Texas_Heart) is available at www.texasheart.org.
(Credit: James Philpot/Texas Heart Institute) The Texas Heart Institute (THI), founded by world-renowned cardiovascular surgeon Dr. Denton A. Cooley in 1962, is a nonprofit organization dedicated to reducing the devastating toll of cardiovascular disease through innovative and progressive programs in research, education and improved patient care. More information about THI (@Texas_Heart) is available at www.texasheart.org.

Abstract:
Thin, flexible fibers made of carbon nanotubes have now proven able to bridge damaged heart tissues and deliver the electrical signals needed to keep those hearts beating.

Damaged hearts rewired with nanotube fibers: Texas Heart doctors confirm Rice-made, conductive carbon threads are electrical bridges

Houston, TX | Posted on August 14th, 2019

Scientists at Texas Heart Institute (THI) report they have used biocompatible fibers invented at Rice University in studies that showed sewing them directly into damaged tissue can restore electrical function to hearts.

"Instead of shocking and defibrillating, we are actually correcting diseased conduction of the largest major pumping chamber of the heart by creating a bridge to bypass and conduct over a scarred area of a damaged heart," said Dr. Mehdi Razavi, a cardiologist and director of Electrophysiology Clinical Research and Innovations at THI, who co-led the study with Rice chemical and biomolecular engineer Matteo Pasquali.

"Today there is no technology that treats the underlying cause of the No. 1 cause of sudden death, ventricular arrhythmias," Razavi said. "These arrhythmias are caused by the disorganized firing of impulses from the heart's lower chambers and are challenging to treat in patients after a heart attack or with scarred heart tissue due to such other conditions as congestive heart failure or dilated cardiomyopathy."

Results of the studies on preclinical models appear as an open-access Editor's Pick in the American Heart Association's Circulation: Arrhythmia and Electrophysiology. The association helped fund the research with a 2015 grant.

The research springs from the pioneering 2013 invention by Pasquali's lab of a method to make conductive fibers out of carbon nanotubes. The lab's first threadlike fibers were a quarter of the width of a human hair, but contained tens of millions of microscopic nanotubes. The fibers are also being studied for electrical interfaces with the brain, for use in cochlear implants, as flexible antennas and for automotive and aerospace applications.

The experiments showed the nontoxic, polymer-coated fibers, with their ends stripped to serve as electrodes, were effective in restoring function during monthlong tests in large preclinical models as well as rodents, whether the initial conduction was slowed, severed or blocked, according to the researchers. The fibers served their purpose with or without the presence of a pacemaker, they found.

In the rodents, they wrote, conduction disappeared when the fibers were removed.

"The reestablishment of cardiac conduction with carbon nanotube fibers has the potential to revolutionize therapy for cardiac electrical disturbances, one of the most common causes of death in the United States," said co-lead author Mark McCauley, who carried out many of the experiments as a postdoctoral fellow at THI. He is now an assistant professor of clinical medicine at the University of Illinois College of Medicine.

"Our experiments provided the first scientific support for using a synthetic material-based treatment rather than a drug to treat the leading cause of sudden death in the U.S. and many developing countries around the world," Razavi added.

Many questions remain before the procedure can move toward human testing, Pasquali said. The researchers must establish a way to sew the fibers in place using a minimally invasive catheter, and make sure the fibers are strong and flexible enough to serve a constantly beating heart over the long term. He said they must also determine how long and wide fibers should be, precisely how much electricity they need to carry and how they would perform in the growing hearts of young patients.

"Flexibility is important because the heart is continuously pulsating and moving, so anything that's attached to the heart's surface is going to be deformed and flexed," said Pasquali, who has appointments at Rice's Brown School of Engineering and Wiess School of Natural Sciences.

"Good interfacial contact is also critical to pick up and deliver the electrical signal," he said. "In the past, multiple materials had to be combined to attain both electrical conductivity and effective contacts. These fibers have both properties built in by design, which greatly simplifies device construction and lowers risks of long-term failure due to delamination of multiple layers or coatings."

Razavi noted that while there are many effective antiarrhythmic drugs available, they are often contraindicated in patients after a heart attack. "What is really needed therapeutically is to increase conduction," he said. “Carbon nanotube fibers have the conductive properties of metal but are flexible enough to allow us to navigate and deliver energy to a very specific area of a delicate, damaged heart."

Rice alumna Flavia Vitale, now an assistant professor of neurology and of physical medicine and rehabilitation at the University of Pennsylvania, and Stephen Yan, a graduate student at Rice, are co-lead authors of the paper.

Co-authors are Colin Young and Julia Coco of Rice; Brian Greet of THI and Baylor St. Luke's Medical Center; Marco Orecchioni and Lucia Delogu of the Città della Speranza Pediatric Research Institute, Padua, Italy; Abdelmotagaly Elgalad, Mathews John, Doris Taylor and Luiz Sampaio, all of THI; and Srikanth Perike of the University of Illinois at Chicago. Pasquali is the A.J. Hartsook Professor of Chemical and Biomolecular Engineering, a professor of materials science and nanoengineering and of chemistry.

The American Heart Association, the Welch Foundation, the Air Force Office of Scientific Research, the National Institutes of Health and Louis Magne supported the research.

####

About Rice University
Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,962 undergraduates and 3,027 graduate students, Rice’s undergraduate student-to-faculty ratio is just under 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for lots of race/class interaction and No. 2 for quality of life by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance.

Follow Rice News and Media Relations via Twitter @RiceUNews.

For more information, please click here

Contacts:
David Ruth
713-348-6327


Mike Williams
713-348-6728


AT TEXAS HEART INSTITUTE:
Keri Sprung
832-355-9240

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Read the paper at:

Nanotube fibers being tested as a way to restore electrical health to hearts:

Pasquali Research Group:

Electrophysiology Clinical Research and Innovations:

Flavia Vitale Lab:

Mark McCauley, MD/Ph.D.:

Related News Press

News and information

Cyborg heart could help scientists better understand the human organ August 21st, 2019

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

A first for cancer research’: New approach to study tumors August 20th, 2019

Stanford builds a heat shield just 10 atoms thick to protect electronic devices: Atomically thin heat shields could be up to 50,000 times thinner than current insulating materials in cell phones and laptops August 19th, 2019

Govt.-Legislation/Regulation/Funding/Policy

Cyborg heart could help scientists better understand the human organ August 21st, 2019

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

Stanford builds a heat shield just 10 atoms thick to protect electronic devices: Atomically thin heat shields could be up to 50,000 times thinner than current insulating materials in cell phones and laptops August 19th, 2019

uSEE breakthrough unlocks the nanoscale world on standard biology lab equipment August 16th, 2019

Possible Futures

Cyborg heart could help scientists better understand the human organ August 21st, 2019

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

A first for cancer research’: New approach to study tumors August 20th, 2019

Stanford builds a heat shield just 10 atoms thick to protect electronic devices: Atomically thin heat shields could be up to 50,000 times thinner than current insulating materials in cell phones and laptops August 19th, 2019

Nanotubes/Buckyballs/Fullerenes/Nanorods

Rice lab produces simple fluorescent surfactants: Compounds show promise for use in medicine, manufacturing August 5th, 2019

Oddball edge wins nanotube faceoff: Rice U. theory shows peculiar 'Janus' interface a common mechanism in carbon nanotube growth July 29th, 2019

Skoltech scientists developed a novel method to fine-tune the properties of carbon nanotubes July 24th, 2019

Making graphene-based desalination membranes less prone to defects, better at separating June 13th, 2019

Nanomedicine

Cyborg heart could help scientists better understand the human organ August 21st, 2019

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

A first for cancer research’: New approach to study tumors August 20th, 2019

Optofluidic chip with nanopore 'smart gate' developed for single molecule analysis: Programmable device enables on-demand delivery of individual biomolecules with feedback-controlled gating for high-throughput analysis August 16th, 2019

Discoveries

Cyborg heart could help scientists better understand the human organ August 21st, 2019

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

A first for cancer research’: New approach to study tumors August 20th, 2019

Stanford builds a heat shield just 10 atoms thick to protect electronic devices: Atomically thin heat shields could be up to 50,000 times thinner than current insulating materials in cell phones and laptops August 19th, 2019

Announcements

Cyborg heart could help scientists better understand the human organ August 21st, 2019

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

A first for cancer research’: New approach to study tumors August 20th, 2019

Stanford builds a heat shield just 10 atoms thick to protect electronic devices: Atomically thin heat shields could be up to 50,000 times thinner than current insulating materials in cell phones and laptops August 19th, 2019

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Cyborg heart could help scientists better understand the human organ August 21st, 2019

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

A first for cancer research’: New approach to study tumors August 20th, 2019

Stanford builds a heat shield just 10 atoms thick to protect electronic devices: Atomically thin heat shields could be up to 50,000 times thinner than current insulating materials in cell phones and laptops August 19th, 2019

Military

Stanford builds a heat shield just 10 atoms thick to protect electronic devices: Atomically thin heat shields could be up to 50,000 times thinner than current insulating materials in cell phones and laptops August 19th, 2019

You're not so tough, h-BN: Rice University chemists find new path to make strong 2D material better for applications August 14th, 2019

Sharp meets flat in tunable 2D material: Rice's new atom-flat compounds show promise for optoelectronics, advanced computing August 12th, 2019

Oddball edge wins nanotube faceoff: Rice U. theory shows peculiar 'Janus' interface a common mechanism in carbon nanotube growth July 29th, 2019

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

Stanford builds a heat shield just 10 atoms thick to protect electronic devices: Atomically thin heat shields could be up to 50,000 times thinner than current insulating materials in cell phones and laptops August 19th, 2019

You're not so tough, h-BN: Rice University chemists find new path to make strong 2D material better for applications August 14th, 2019

Researchers embrace imperfection to improve biomolecule transport August 8th, 2019

Nanobiotechnology

Cyborg heart could help scientists better understand the human organ August 21st, 2019

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

uSEE breakthrough unlocks the nanoscale world on standard biology lab equipment August 16th, 2019

Probing the Origin of Alzheimer’s . . . with Transistors: Novel high-sensitivity detector could aid in early diagnosis August 15th, 2019

Research partnerships

Research brief: A novel cellular process to engulf nano-sized materials August 20th, 2019

A first for cancer research’: New approach to study tumors August 20th, 2019

Optofluidic chip with nanopore 'smart gate' developed for single molecule analysis: Programmable device enables on-demand delivery of individual biomolecules with feedback-controlled gating for high-throughput analysis August 16th, 2019

Nanoparticles’ movement reveals whether they can successfully target cancer: Targeting nanoparticles rotate faster and move across larger areas August 9th, 2019

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project