Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Extracellular vesicles could be personalized drug delivery vehicles

This image shows ligands-grafted extracellular vesicles as drug delivery vehicles.
CREDIT
Xin Zou
This image shows ligands-grafted extracellular vesicles as drug delivery vehicles. CREDIT Xin Zou

Abstract:
Creating enough nanovesicles to inexpensively serve as a drug delivery system may be as simple as putting the cells through a sieve, according to an international team of researchers who used mouse autologous -- their own -- immune cells to create large amounts of fillable nanovesicles to deliver drugs to tumors in mice.

Extracellular vesicles could be personalized drug delivery vehicles

University Park, PA | Posted on March 15th, 2018

Nanovesicles are tiny sacs released by cells that carry chemical messages between cells. These nanovesicles are natural delivery vehicle and useful in drug delivery for cancer treatment.

"Currently, natural nanovesicles can be harvested from cell culture supernatant (the fluid surrounding cultured cells) and they are fillable," said Yuan Wan, postdoctoral fellow in biomedical engineering, Penn State. "However, there are two problems using them for cancer treatment. There aren't enough nanovesicles produced in short timescales and they do not have targeting effect."

The researchers developed an approach and platform to create large amounts of fillable and targeted nanovesicles. They report their results in a recent issue of Cancer Research.

To create targeted nanovesicles, ligands -- perhaps short pieces of protein -- need to be attached to the nanovesicle wall so they can recognize tumor cells. The process for making targeted nanovesicles now requires using viruses to insert relevant DNA fragments into the genome of the donor cells and then collecting ligand-bearing nanovesicles released from the gene-modified cells.

Yuan, working with Si-Yang Zheng, associated professor of biomedical engineering, developed a simpler and faster method for attaching ligands. The researchers chemically graft the lipid-tagged ligands onto the cell membrane. They do this before they pass the cells through a sieve, which converts the cell membranes into millions of vesicles bearing ligands that can be filled with an appropriate drug to target the cancer.

"Pushing the cells through a filter is the engineered way to produce lots of nanovesicles," said Zheng.

The researchers used mouse autologous immune cells and created the ligand-targeted, fillable nanovesicles in the laboratory. They then infused these drug-loaded nanovesicles into the original mouse to treat tumors.

"This approach enables us to create nanovesicles with different ligands targeting different types of tumors in about 30 minutes to meet actual needs," said Zheng. "With this approach, we also can put different types of ligands on a nanovesicle. We could have one ligand that targets while another ligand says, 'don't eat me.'"

Zheng is referring to the body's propensity to clear materials that do not belong from the blood stream. If a nanovesicle has a ligand attached that suggests the vesicle is autologous, then the vesicle, and its drug payload, might remain in circulation longer, making it more successful in finding and killing the target cancer cells.

The researchers believe that a variety of other cells, including stem cells, T cells -- cells of the immune system -- and other cell types could be modified and used as donor cells for extrusion of nanovesicles.

###

Also working on the project at Penn State were Yiqiu Xia, graduate student in biomedical engineering, and Gong Cheng, former postdoctoral fellow in biomedical engineering.

Others working on this project include Chuandong Zhu, Qin Zheng, Jinlong Tong and Yuan Fang, Second Affiliated Hospital of Southeast University; Lixue Wang, Second Affiliated Hospital of Southeast University and Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research; and Xia He, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research; all in Nanjing, China.

The Nanjing Science and Technology Development Foundation, Jiangsu Provincial Medical Youth Talent Award, Natural Science Foundation of Jiangsu Province and the U.S. National Institutes of Health supported this work.

####

For more information, please click here

Contacts:
A'ndrea Elyse Messer

814-865-9481

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

Cancer

Rice U. lab probes molecular limit of plasmonics: Optical effect detailed in organic molecules with fewer than 50 atoms September 5th, 2018

Polymer antibodies efficiently target and eliminate cancer cells August 27th, 2018

New technology can detect hundreds of proteins in a single sample: Improvement of barcoding technique offers cost-effective alternative to current technology August 13th, 2018

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Govt.-Legislation/Regulation/Funding/Policy

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Could a demon help to create a quantum computer? Physicists implement a version of Maxwell's famous thought experiment for reducing entropy September 5th, 2018

Ultracold atoms used to verify 1963 prediction about 1D electrons: Rice University, University of Geneva study focuses on theory that's increasingly relevant to chipmakers September 5th, 2018

Possible Futures

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

Nanomedicine

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

A Comprehensive Guide: The Future of Nanotechnology September 13th, 2018

Carbon nanodots do an ultrafine job with in vitro lung tissue: New experiments highlight the role of charge and size when it comes to carbon nanodots that mimic the effect of nanoscale pollution particles on the human lung. September 12th, 2018

Rice U. lab probes molecular limit of plasmonics: Optical effect detailed in organic molecules with fewer than 50 atoms September 5th, 2018

Discoveries

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Announcements

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

How a tetrahedral substance can be more symmetrical than a spherical atom: A new type of symmetry September 14th, 2018

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

A Comprehensive Guide: The Future of Nanotechnology September 13th, 2018

Rice U. lab probes molecular limit of plasmonics: Optical effect detailed in organic molecules with fewer than 50 atoms September 5th, 2018

Nanobiotechnology

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Neutrophil nanosponges soak up proteins that promote rheumatoid arthritis September 3rd, 2018

Arrowhead Pharmaceuticals to Present at Upcoming September 2018 Conferences August 31st, 2018

A human enzyme can biodegrade graphene August 28th, 2018

Research partnerships

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project