Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Block copolymer micellization as a protection strategy for DNA origami

DNA origami.
CREDIT
cfaed
DNA origami. CREDIT cfaed

Abstract:
The precise positioning of individual molecules with respect to one another is fundamentally challenging. DNA Nanotechnology enables the synthesis of nanometer-sized objects with programmable shapes out of many chemically produced DNA fragments. One of the most widely used methods in this field is called "DNA origami" which allows to fabricate nanoparticles with almost arbitrary shapes, which are around a thousand-fold smaller than the diameter of a human hair. They can be site-specifically functionalized with a large variety of materials such as individual protein molecules, antibodies, drugs molecules or inorganic nanoparticles. This allows to place them in defined geometries or distances with nanometer precision.

Block copolymer micellization as a protection strategy for DNA origami

Dresden, Germany | Posted on March 17th, 2017

Due to this unique control over matter on the nanometer-scale, DNA nanostructures have also been considered for applications in molecular biology and nanomedicine. For example, they can be used as programmable drug carriers, diagnostic devices or to study the response of cells to precisely arranged molecules. However, many of these artificial DNA nanostructures need a much higher salt concentration than that in bodily fluids or cell culture buffers to maintain their structure and thus their functionality. Moreover, they can be degraded quickly by special enzymes (nucleases) that are present in bodily fluids such as saliva or blood that digest foreign DNA. This instability limits any biological or medical applications.

To overcome this deficiency, a team led by cfaed Research Group Leader Dr. Thorsten L. Schmidt (Technische Universität Dresden / Germany) coated several different DNA origami structures with a synthetic polymer. This polymer consists of two segments, a short positively charged segment which electrostatically "glues" the polymer to the negatively charged DNA nanostructure and a long uncharged polymer chain that covers the entire nanostructure resembling a fur. In their study "Block Copolymer Micellization as a Protection Strategy for DNA Origami" published in Angewandte Chemie [DOI: 10.1002/anie.201608873] they showed that such DNA nanostructures covered with the polymers were protected against nuclease digestion and low salt conditions. Furthermore they showed that structures functionalized with nanoparticles can be protected by the same mechanism.

This straightforward, cost-effective and robust route to protect DNA-based structures could therefore enable applications in biology and nanomedicine, where un-protected DNA origami would be degraded.


About cfaed

cfaed is a microelectronics research cluster funded by the German Excellence Initiative. It comprises 11 cooperating institutes in Saxony. About 300 scientists from more than 20 countries investigate new technologies for electronic information processing. These technologies are inspired by innovative materials such as silicon nanowires, carbon nanotubes or polymers or based on completely new concepts such as the chemical chip or circuit fabrication methods by self-assembling structures such as DNA-Origami. The orchestration of these new devices into heterogeneous information processing systems with focus on their resilience and energy-efficiency is also part of cfaed's research program which comprises nine different research paths. http://www.cfaed.tu-dresden.de

####

For more information, please click here

Contacts:
Matthias Hahndorf

49-035-146-342-847

Thorsten-Lars Schmidt, PhD.
Group Leader DNA Chemistry

Copyright © Technische Universität Dresden

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Paper:

Related News Press

News and information

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Nanoparticles could spur better LEDs, invisibility cloaks July 19th, 2017

Possible Futures

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Here's a tip: Indented cement shows unique properties: Rice University models reveal nanoindentation can benefit crystals in concrete July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Nanomedicine

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

'Upconverted' light has a bright future: Rice University professor developing plasmon-powered devices for medicine, security, solar cells July 17th, 2017

Researchers revolutionize vital conservation tool with use of gold nanotechnology and lasers: Cryopreservation study results have sweeping implications for wildlife conservation and human health July 15th, 2017

Nanomedicine opens door to precision medicine for brain tumors July 12th, 2017

Discoveries

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Here's a tip: Indented cement shows unique properties: Rice University models reveal nanoindentation can benefit crystals in concrete July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Announcements

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Here's a tip: Indented cement shows unique properties: Rice University models reveal nanoindentation can benefit crystals in concrete July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Here's a tip: Indented cement shows unique properties: Rice University models reveal nanoindentation can benefit crystals in concrete July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Nanobiotechnology

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Researchers revolutionize vital conservation tool with use of gold nanotechnology and lasers: Cryopreservation study results have sweeping implications for wildlife conservation and human health July 15th, 2017

Nanomedicine opens door to precision medicine for brain tumors July 12th, 2017

Nature-inspired material uses liquid reinforcement: Rice U. nanoengineers create liquid-solid composites using clues from nature July 11th, 2017

Research partnerships

Studying Argon Gas Trapped in Two-Dimensional Array of Tiny "Cages": Understanding how individual atoms enter and exit the nanoporous frameworks could help scientists design new materials for gas separation and nuclear waste remediation July 17th, 2017

Coupling a nano-trumpet with a quantum dot enables precise position determination July 14th, 2017

GLOBALFOUNDRIES and VeriSilicon To Enable Single-Chip Solution for Next-Gen IoT Networks: Integrated solution leverages GF’s 22FDX® technology to decrease power, area, and cost for NB-IoT and LTE-M applications July 14th, 2017

Carbon displays quantum effects July 13th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project