Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Block copolymer micellization as a protection strategy for DNA origami

DNA origami.
CREDIT
cfaed
DNA origami. CREDIT cfaed

Abstract:
The precise positioning of individual molecules with respect to one another is fundamentally challenging. DNA Nanotechnology enables the synthesis of nanometer-sized objects with programmable shapes out of many chemically produced DNA fragments. One of the most widely used methods in this field is called "DNA origami" which allows to fabricate nanoparticles with almost arbitrary shapes, which are around a thousand-fold smaller than the diameter of a human hair. They can be site-specifically functionalized with a large variety of materials such as individual protein molecules, antibodies, drugs molecules or inorganic nanoparticles. This allows to place them in defined geometries or distances with nanometer precision.

Block copolymer micellization as a protection strategy for DNA origami

Dresden, Germany | Posted on March 17th, 2017

Due to this unique control over matter on the nanometer-scale, DNA nanostructures have also been considered for applications in molecular biology and nanomedicine. For example, they can be used as programmable drug carriers, diagnostic devices or to study the response of cells to precisely arranged molecules. However, many of these artificial DNA nanostructures need a much higher salt concentration than that in bodily fluids or cell culture buffers to maintain their structure and thus their functionality. Moreover, they can be degraded quickly by special enzymes (nucleases) that are present in bodily fluids such as saliva or blood that digest foreign DNA. This instability limits any biological or medical applications.

To overcome this deficiency, a team led by cfaed Research Group Leader Dr. Thorsten L. Schmidt (Technische Universitšt Dresden / Germany) coated several different DNA origami structures with a synthetic polymer. This polymer consists of two segments, a short positively charged segment which electrostatically "glues" the polymer to the negatively charged DNA nanostructure and a long uncharged polymer chain that covers the entire nanostructure resembling a fur. In their study "Block Copolymer Micellization as a Protection Strategy for DNA Origami" published in Angewandte Chemie [DOI: 10.1002/anie.201608873] they showed that such DNA nanostructures covered with the polymers were protected against nuclease digestion and low salt conditions. Furthermore they showed that structures functionalized with nanoparticles can be protected by the same mechanism.

This straightforward, cost-effective and robust route to protect DNA-based structures could therefore enable applications in biology and nanomedicine, where un-protected DNA origami would be degraded.


About cfaed

cfaed is a microelectronics research cluster funded by the German Excellence Initiative. It comprises 11 cooperating institutes in Saxony. About 300 scientists from more than 20 countries investigate new technologies for electronic information processing. These technologies are inspired by innovative materials such as silicon nanowires, carbon nanotubes or polymers or based on completely new concepts such as the chemical chip or circuit fabrication methods by self-assembling structures such as DNA-Origami. The orchestration of these new devices into heterogeneous information processing systems with focus on their resilience and energy-efficiency is also part of cfaed's research program which comprises nine different research paths. http://www.cfaed.tu-dresden.de

####

For more information, please click here

Contacts:
Matthias Hahndorf

49-035-146-342-847

Thorsten-Lars Schmidt, PhD.
Group Leader DNA Chemistry

Copyright © Technische Universitšt Dresden

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Paper:

Related News Press

News and information

The lightest shielding material in the world: Protection against electromagnetic interference July 3rd, 2020

Spintronics: Faster data processing through ultrashort electric pulses July 3rd, 2020

A path to new nanofluidic devices applying spintronics technology: Substantial increase in the energy conversion efficiency of hydrodynamic power generation via spin currents July 3rd, 2020

Towards lasers powerful enough to investigate a new kind of physics: An international team of researchers has demonstrated an innovative technique for increasing the intensity of lasers July 3rd, 2020

Possible Futures

Spintronics: Faster data processing through ultrashort electric pulses July 3rd, 2020

A path to new nanofluidic devices applying spintronics technology: Substantial increase in the energy conversion efficiency of hydrodynamic power generation via spin currents July 3rd, 2020

Towards lasers powerful enough to investigate a new kind of physics: An international team of researchers has demonstrated an innovative technique for increasing the intensity of lasers July 3rd, 2020

Crystal structure discovered almost 200 years ago could hold key to solar cell revolution July 3rd, 2020

Nanomedicine

Charcoal a weapon to fight superoxide-induced disease, injury: Nanomaterials soak up radicals, could aid treatment of COVID-19 July 2nd, 2020

Cellulose for manufacturing advanced materials: A review of the scientific literature made at the University of the Basque Country (UPV/EHU) highlights the potential of hybrid materials based on cellulose nanocrystals June 26th, 2020

Wearable patch may provide new treatment option for skin cancer June 18th, 2020

Tiny pump builds polyrotaxanes with precision: Artificial molecular pump gives precise control for materials design June 12th, 2020

Discoveries

The lightest shielding material in the world: Protection against electromagnetic interference July 3rd, 2020

Spintronics: Faster data processing through ultrashort electric pulses July 3rd, 2020

A path to new nanofluidic devices applying spintronics technology: Substantial increase in the energy conversion efficiency of hydrodynamic power generation via spin currents July 3rd, 2020

Towards lasers powerful enough to investigate a new kind of physics: An international team of researchers has demonstrated an innovative technique for increasing the intensity of lasers July 3rd, 2020

Announcements

Towards lasers powerful enough to investigate a new kind of physics: An international team of researchers has demonstrated an innovative technique for increasing the intensity of lasers July 3rd, 2020

Crystal structure discovered almost 200 years ago could hold key to solar cell revolution July 3rd, 2020

Flexible material shows potential for use in fabrics to heat, cool July 3rd, 2020

Carbon-loving materials designed to reduce industrial emissions July 3rd, 2020

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

A path to new nanofluidic devices applying spintronics technology: Substantial increase in the energy conversion efficiency of hydrodynamic power generation via spin currents July 3rd, 2020

Towards lasers powerful enough to investigate a new kind of physics: An international team of researchers has demonstrated an innovative technique for increasing the intensity of lasers July 3rd, 2020

Crystal structure discovered almost 200 years ago could hold key to solar cell revolution July 3rd, 2020

Flexible material shows potential for use in fabrics to heat, cool July 3rd, 2020

Nanobiotechnology

Charcoal a weapon to fight superoxide-induced disease, injury: Nanomaterials soak up radicals, could aid treatment of COVID-19 July 2nd, 2020

Cellulose for manufacturing advanced materials: A review of the scientific literature made at the University of the Basque Country (UPV/EHU) highlights the potential of hybrid materials based on cellulose nanocrystals June 26th, 2020

Wearable patch may provide new treatment option for skin cancer June 18th, 2020

Prodigiosin-based solution has selective activity against cancer cells: A new nanoformulation was described by Kazan University's Bionanotechnology Lab in Frontiers in Bioengineering and Biotechnology June 12th, 2020

Research partnerships

Cellulose for manufacturing advanced materials: A review of the scientific literature made at the University of the Basque Country (UPV/EHU) highlights the potential of hybrid materials based on cellulose nanocrystals June 26th, 2020

Argonne researchers create active material out of microscopic spinning particles May 29th, 2020

Surrey reveals its implantable biosensor that operates without batteries May 22nd, 2020

Scientists use light to accelerate supercurrents, access forbidden light, quantum world May 21st, 2020

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project