Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection

Professor Ramesh Wigneshweraraj and his PhD student, Amy Switzer with their ONI Nanoimager (foreground black box) - single molecule super-resolution microscopy on the bench!
Professor Ramesh Wigneshweraraj and his PhD student, Amy Switzer with their ONI Nanoimager (foreground black box) - single molecule super-resolution microscopy on the bench!

Abstract:
Oxford Nanoimaging Limited manufacture and sell microscopes offering super-resolution and single-molecule performance to research users. Today, the company reports on the work of early-adopters for their Nanoimager technology at the MRC Centre for Molecular Bacteriology and Infection located at Imperial College, London.

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection

Oxford, UK | Posted on November 22nd, 2016

The MRC Centre for Molecular Bacteriology and Infection is uniquely focused on disease-causing bacteria. Ramesh Wigneshweraraj is a Professor of Microbiology leading a group that is working at the leading edge of understanding the behaviour of small proteins produced by viruses that infect bacteria (phages) at the single cell level to ultimately inspire and inform the development of truly novel drugs against antibiotic-resistant bacterial pathogens.

Networking in science is so often the provider for new discoveries and collaborations. A meeting at Cambridge proved the point here with Professor Wigneshweraraj (Ramesh) meeting Oxford physicist, Professor Achillefs Kapanidis of the Clarendon Laboratory. Discussing their research over a drink on a warm summer evening, Professor Kapanidis pulled out his laptop and showed results of an experiment very relevant to that being defined by his colleague, Ramesh. One thing led to another and an early demonstration for the Nanoimager, a high resolution single molecule imaging technique developed over a number of years by the Kapanidis group. When, in May 2016, newly-formed company Oxford Nanoimaging (ONI) launched the commercial version of the Nanoimager, Ramesh set out to get funding for the system. With support from the Wellcome Trust, one of ONI's first installations was made at Imperial College in September.

Since its arrival, the Nanoimager has been put through its paces by PhD student, Amy Switzer. Without a background in microscopy, Amy has been able to define what she needs from the instrument to satisfy her research needs. Now working alongside ONI's development team, she is evaluating new data processing software to enable her to produce data at the super-resolution levels. Having a multifunctional system is enabling her to use a variety of imaging methods to achieve live cell imaging at the single molecule level. Techniques at the single molecule level including immunofluorescence, tracking PALM and dSTORM, will now help Amy and Ramesh to work quickly on their goal – the rapid evaluation of how phage-derived small proteins inhibit bacteria and how bacterial enzymes behave in response to the diverse stresses they are subjected to. The Nanoimager, seen below, is a very small unit measuring just 21 cm x 21 cm. It requires no special environmental conditions like an isolation table as it has been designed to compensate for acoustic and vibrational issues. As Amy says, “I am very fortunate to be one of the first users of the Nanoimager. I can work directly with the inventors including Bo Jing from the Kapanidis team. I am able to request new iterations of software and these are delivered with enthusiasm by the ONI folks.”

Timing is very important and here Ramesh takes up the story. “My meeting with Achillefs and the acquisition of the Nanoimager has come at the right time for my research needs. It enables me to understand the behaviour of individual proteins within single bacterial cells. Given the appropriate experimental protocols, I am able to easily detect specific proteins in mixed populations of bacteria. Looking ahead, I can envisage an application of the NanoImager in early diagnostics of bacterial infections, thus enabling rapid species identification and ensuring the correct medication is prescribed, and thereby improving patient welfare while reducing costs. We are really excited to work with ONI in the on-going development of diverse applications for the Nanoimager and, more importantly, to advance fundamental bacteriology in this new and exciting direction.”

Oxford Nanoimaging has launched a new website providing insight into the applications and technology of the Nanoimager. Visit www.oxfordni.com for more information.

####

About Oxford Nanoimaging Limited
Oxford Nanoimaging Limited is a company originating in the Clarendon Laboratory, Department of Physics at the University of Oxford. Professor Achillefs Kapanidis and PhD student, Bo Jing, lead a collaborative, inter-disciplinary team that has pioneered innovative technologies to produce an elegant benchtop super-resolution microscope. The Nanoimager has a footprint of just 21 cm x 21 cm yet packs the capability of a much larger, conventional microscopy platform delivering super-resolution and single-molecule performance. With a significantly lower cost of entry, researchers will now be able to obtain benchtop nanoscale imaging at a fraction of the price of earlier systems without the need for a large laboratory and skilled operators. As Professor Kapanidis says, “I wish I had this when I was a graduate student.”

For more information, please click here

Contacts:
Oxford Nanoimaging Limited
King Charles House
Park End Street
Oxford OX1 1JD
T +44 (0)203 319 2170
www.oxfordni.com


Talking Science Limited
39 de Bohun Court
Saffron Walden CB10 2BA
United Kingdom
T +44 (0)1799 521881
M +44 (0)7843 012997
http://www.talking-science.com/

Copyright © Oxford Nanoimaging Limited

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Switching with molecules: Molecular switch will facilitate the development of pioneering electro-optical devices May 25th, 2018

Tunable diamond string may hold key to quantum memory: A process similar to guitar tuning improves storage time of quantum memory May 24th, 2018

Remote control of transport through nanopores: New study outlines key factors affecting the transfer of molecules through biological channels May 24th, 2018

2018 Kavli Prizes in Astrophysics, Nanoscience, and Neuroscience to be Announced Live on May 31: Live announcement at the Norwegian Academy of Science and Letters to be streamed live at World Science Festival Event May 24th, 2018

Columbia Researchers Squeeze Light into Nanoscale Devices and Circuits: Team is first to directly image propagation and dynamics of graphene plasmons at very low temperatures; findings could impact optical communications and signal processing May 23rd, 2018

Imaging

Columbia Researchers Squeeze Light into Nanoscale Devices and Circuits: Team is first to directly image propagation and dynamics of graphene plasmons at very low temperatures; findings could impact optical communications and signal processing May 23rd, 2018

NIST Puts the Optical Microscope Under the Microscope to Achieve Atomic Accuracy May 22nd, 2018

Elastic microspheres expand understanding of embryonic development and cancer cells May 15th, 2018

Academic/Education

Grand Opening of UC Irvine Materials Research Institute (IMRI) to Spotlight JEOL Center for Nanoscale Solutions: Renowned Materials Scientists to Present at the 1st International Symposium on Advanced Microscopy and Spectroscopy (ISAMS) April 18th, 2018

Lifeboat Foundation funds flying 3D-printed classroom cubesats with Perlan II April 16th, 2018

SUNY Poly’s Center for Semiconductor Research in Albany Earns World-Class TÜV SÜD AMERICA INC. ISO 9001:2015 Certification: Albany NanoTech Complex Certification Assures Top-Tier Quality in Semiconductor Test Structures; Certification a First for a SUNY Campus March 6th, 2018

Luleå University of Technology is using the Deben CT5000TEC stage to perform x-ray microtomography experiments with the ZEISS Xradia 510 Versa to understand deformation and strain inside inhomogeneous materials November 7th, 2017

Announcements

Switching with molecules: Molecular switch will facilitate the development of pioneering electro-optical devices May 25th, 2018

Tunable diamond string may hold key to quantum memory: A process similar to guitar tuning improves storage time of quantum memory May 24th, 2018

Remote control of transport through nanopores: New study outlines key factors affecting the transfer of molecules through biological channels May 24th, 2018

2018 Kavli Prizes in Astrophysics, Nanoscience, and Neuroscience to be Announced Live on May 31: Live announcement at the Norwegian Academy of Science and Letters to be streamed live at World Science Festival Event May 24th, 2018

Tools

Columbia Researchers Squeeze Light into Nanoscale Devices and Circuits: Team is first to directly image propagation and dynamics of graphene plasmons at very low temperatures; findings could impact optical communications and signal processing May 23rd, 2018

NIST Puts the Optical Microscope Under the Microscope to Achieve Atomic Accuracy May 22nd, 2018

Self-assembling 3D battery would charge in seconds May 22nd, 2018

A micro-thermometer to record tiny temperature changes May 15th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project