Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > New Ebola test could help curb disease spread: Using magnetic nanoparticles means simpler, cheaper diagnosis

Abstract:
A new Ebola test that uses magnetic nanoparticles could help curb the spread of the disease in western Africa. Research published in Biosensors and Bioelectronics shows that the new test is 100 times more sensitive than the current test, and easier to use. Because of this, the new test makes it easier and cheaper to diagnose cases, enabling healthcare workers to isolate patients and prevent the spread of Ebola.

New Ebola test could help curb disease spread: Using magnetic nanoparticles means simpler, cheaper diagnosis

Eindhoven, the Netherlands | Posted on September 9th, 2015

The authors of the study, from the Chinese Academy of Sciences, say their new technology could be applied to the detection of any biological molecules, making it useful to diagnose other infectious diseases, like flu, and potentially detect tumors and even contamination in wastewater.

The Ebola virus causes an acute illness that is deadly in half of all cases, on average. The current outbreak of Ebola, which started in March 2014, affects countries in west Africa. In the most severely affected countries, like Guinea, Liberia and Sierra Leone, resources are limited, making control of the outbreak challenging. There is no vaccine for Ebola, so detecting the virus is key to controlling the outbreak: with an accurate diagnosis, patients can be isolated and treated properly, reducing the risk of spread.

"In west Africa, resources are under pressure, so complicated, expensive tests are not very helpful," said Professor Xiyun Yan, one of the authors of the study from the Chinese Academy of Sciences. "Our new strip test is a simple, one-step test that is cheap and easy to use, and provides a visible signal, which means people don't need training to use it. We think it will be especially helpful in rural areas, where technical equipment and skills are not available."

Currently there are two ways to test for the Ebola virus: using a method called polymerase chain reaction (PCR), which makes copies of the molecules for detection, and with antibody-capture enzyme-linked immunosorbent assay (ELISA), which gives a visual indication when a given molecule is in a sample. PCR is very sensitive, but is expensive and complicated, requiring special skills and technical equipment. The ELISA - or gold strip test - is cheaper but sensitivity is very low, which means it often gives the wrong results.

The new test, called the nanozyme test, uses magnetic nanoparticles, which work like enzymes to make the signal stronger, giving a clearer result you can see with the naked eye. The test can detect much smaller amounts of the virus, and is 100 times more sensitive than the gold strip test.

"People have loved the strip test for many years, but it has a major weakness: it's not sensitive enough. We're very excited about our new nanozyme test, as it is much more sensitive and you don't need any specialist equipment to get a quick, accurate result," said Dr. Yan.

Strip tests work by attaching molecules called antibodies to gold particles to look for a particular molecule in a sample. When they attach to the molecule you're looking for, in this case a virus, they produce a signal, such as a color change. In order to find the virus, the particles need to be labelled with enzymes, which speed up detection and signalling.

With the new nanozyme test, the researchers applied magnetic nanoparticles as a nanozyme probe in place of gold nanoparticles. After labeling with an antibody that attaches to the Ebola virus, this novel probe is able to recognize and separate the virus in a sample. The nanoparticles are magnetic, so to concentrate the virus particles in a sample, all you need to do is hold the sample against a magnet; no expensive equipment is needed.

The nanozyme test is 100 times more sensitive than the gold strip test, detecting molecules called glycoproteins on the surface of the Ebola virus at concentrations as low as 1 nanogram per milliliter.

The researchers have applied for a patent for the new test, which is currently being taken to west Africa by the CDC to use in the field. The researchers are also collaborating with clinical teams to apply the technology to other diseases, and with a company that treats wastewater to see if it can help remove environmental contamination.

###

Article details

"Nanozyme-strip for rapid local diagnosis of Ebola" by Demin Duan, Kelong Fan, Dexi Zhang, Shuguang Tan, Mifang Liang, Yang Liu, Jianlin Zhang, Panhe Zhang, Wei Liu, Xiangguo Qiu, Gary P. Kobinger, George Fu Gao, Xiyun Yan (doi: 10.1016/j.bios.2015.05.025). The article appears in Biosensors and Bioelectronics, published by Elsevier.

A copy of the paper is available to credentialed journalists upon request, contact Elsevier's Newsroom at or +31 20 4853564.

####

About Elsevier
Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions -- among them ScienceDirect, Scopus, Elsevier Research Intelligence and ClinicalKey -- and publishes over 2,500 journals, including The Lancet and Cell, and more than 33,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group plc, a world-leading provider of information solutions for professional customers across industries.

About Biosensors and Bioelectronics

Biosensors & Bioelectronics is the principal international journal devoted to research, design, development and application of biosensors and bioelectronics. It is an interdisciplinary journal serving professionals with an interest in the exploitation of biological materials and designs in novel diagnostic and electronic devices including sensors, DNA chips, electronic noses, lab-on-a-chip and μ-TAS. www.journals.elsevier.com/biosensors-and-bioelectronics

For more information, please click here

Contacts:
Darren Sugrue

31-204-853-506

Copyright © Elsevier

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

An EPiQS Pursuit: Physicist Andrea Young is chosen to receive an Experimental Investigator award from the Moore Foundation May 28th, 2020

Study finds electrical fields can throw a curveball: Particle-scale phenomenon akin to the swerving of a curveball could allow selective separation of suspended nanomaterials May 26th, 2020

Surrey reveals its implantable biosensor that operates without batteries May 22nd, 2020

Researchers demonstrate transport of mechanical energy, even through damaged pathways: Topological pump can provide stability for communication technologies May 22nd, 2020

Cancer

Multi-functionalization of graphene for molecular targeted cancer therapy April 24th, 2020

UTEP researchers develop nanohybrid vehicle to optimally deliver drugs into the human body April 23rd, 2020

Nanoparticles: Acidic alert April 17th, 2020

Scientists propose nanoparticles that can treat cancer with magnetic fluid hyperthermia: A group of Russian scientists have synthesized manganese-zinc ferrite nanoparticles that can potentially be used in cancer treatment March 11th, 2020

Nanomedicine

2D sandwich sees molecules with clarity: Rice University engineers adapt 2D ‘sandwich’ for surface-enhanced Raman spectroscopy May 15th, 2020

Twisting 2D materials uncovers their superpowers: Researchers have developed a completely new method for twisting atomically thin materials, paving the way for applications of 'twistronics' based on tunable 2D materials May 12th, 2020

Chemistry breakthrough could speed up drug development: Scientists have successfully developed a new technique to reliably grow crystals of organic soluble molecules from nanoscale droplets, unlocking the potential of accelerated new drug development May 8th, 2020

Engineers and scientists develop mobile technology for eye examinations: Novel photonic integrated technology will bring optical coherence tomography from stationary clinical use to mobile use May 7th, 2020

Sensors

Surrey reveals its implantable biosensor that operates without batteries May 22nd, 2020

Making quantum 'waves' in ultrathin materials: Study co-led by Berkeley Lab reveals how wavelike plasmons could power up a new class of sensing and photochemical technologies at the nanoscale May 15th, 2020

Twisting 2D materials uncovers their superpowers: Researchers have developed a completely new method for twisting atomically thin materials, paving the way for applications of 'twistronics' based on tunable 2D materials May 12th, 2020

MOF material offers optical sensing of NO2 pollutant for air quality measurements April 30th, 2020

Discoveries

Study finds electrical fields can throw a curveball: Particle-scale phenomenon akin to the swerving of a curveball could allow selective separation of suspended nanomaterials May 26th, 2020

MSU scientists solve half-century-old magnesium dimer mystery May 22nd, 2020

Researchers review advances in 3D printing of high-entropy alloys: SUTD collaborates with universities in Singapore and China to shine light on HEA manufacturing processes and inspire further research in this emerging field May 22nd, 2020

A stitch in time: How a quantum physicist invented new code from old tricks: Error suppression opens pathway to universal quantum computing May 22nd, 2020

Announcements

An EPiQS Pursuit: Physicist Andrea Young is chosen to receive an Experimental Investigator award from the Moore Foundation May 28th, 2020

Study finds electrical fields can throw a curveball: Particle-scale phenomenon akin to the swerving of a curveball could allow selective separation of suspended nanomaterials May 26th, 2020

Visualization of functional components to characterize optimal composite electrodes May 22nd, 2020

Researchers demonstrate transport of mechanical energy, even through damaged pathways: Topological pump can provide stability for communication technologies May 22nd, 2020

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Study finds electrical fields can throw a curveball: Particle-scale phenomenon akin to the swerving of a curveball could allow selective separation of suspended nanomaterials May 26th, 2020

Surrey reveals its implantable biosensor that operates without batteries May 22nd, 2020

Visualization of functional components to characterize optimal composite electrodes May 22nd, 2020

Researchers demonstrate transport of mechanical energy, even through damaged pathways: Topological pump can provide stability for communication technologies May 22nd, 2020

Environment

How particulate matter arises from pollutant gases: International research project observes ultrafast particle growth through ammonia and nitric acid May 15th, 2020

2D sandwich sees molecules with clarity: Rice University engineers adapt 2D ‘sandwich’ for surface-enhanced Raman spectroscopy May 15th, 2020

MOF material offers optical sensing of NO2 pollutant for air quality measurements April 30th, 2020

Getting through the bottleneck—A new class of layered perovskite with high oxygen-ion conductivity April 29th, 2020

Water

Two is better than one: Scientists fit two co-catalysts on one nanosheet for better water purification April 16th, 2020

Electric jolt to carbon makes better water purifier March 24th, 2020

Water-free way to make MXenes could mean new uses for the promising nanomaterials: Discovery by Drexel researchers could open new application for MXene materials March 13th, 2020

Extraction of lithium from its largest source, i.e. seawater, by nanostructured membranes January 27th, 2020

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project