Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Biomedical breakthrough: Carbon nanoparticles you can make at home

University of Illinois postdoctoral researcher Prabuddha Mukherjee, left, bioengineering professors Rohit Bhargava and Dipanjan Pan, and postdoctoral researcher Santosh Misra, right, report the development of a new class of carbon nanoparticles for biomedical use.
CREDIT: L. Brian Stauffer
University of Illinois postdoctoral researcher Prabuddha Mukherjee, left, bioengineering professors Rohit Bhargava and Dipanjan Pan, and postdoctoral researcher Santosh Misra, right, report the development of a new class of carbon nanoparticles for biomedical use.

CREDIT: L. Brian Stauffer

Abstract:
Researchers have found an easy way to produce carbon nanoparticles that are small enough to evade the body's immune system, reflect light in the near-infrared range for easy detection, and carry payloads of pharmaceutical drugs to targeted tissues.

Biomedical breakthrough: Carbon nanoparticles you can make at home

Champaign, IL | Posted on June 18th, 2015

Unlike other methods of making carbon nanoparticles - which require expensive equipment and purification processes that can take days - the new approach generates the particles in a few hours and uses only a handful of ingredients, including store-bought molasses.

The researchers, led by University of Illinois bioengineering professors Dipanjan Pan and Rohit Bhargava, report their findings in the journal Small.

"If you have a microwave and honey or molasses, you can pretty much make these particles at home," Pan said. "You just mix them together and cook it for a few minutes, and you get something that looks like char, but that is nanoparticles with high luminescence. This is one of the simplest systems that we can think of. It is safe and highly scalable for eventual clinical use."

These "next-generation" carbon spheres have several attractive properties, the researchers found. They naturally scatter light in a manner that makes them easy to differentiate from human tissues, eliminating the need for added dyes or fluorescing molecules to help detect them in the body.

The nanoparticles are coated with polymers that fine-tune their optical properties and their rate of degradation in the body. The polymers can be loaded with drugs that are gradually released.

The nanoparticles also can be made quite small, less than eight nanometers in diameter (a human hair is 80,000 to 100,000 nanometers thick).

"Our immune system fails to recognize anything under 10 nanometers," Pan said. "So, these tiny particles are kind of camouflaged, I would say; they are hiding from the human immune system."

The team tested the therapeutic potential of the nanoparticles by loading them with an anti-melanoma drug and mixing them in a topical solution that was applied to pig skin.

Bhargava's laboratory used vibrational spectroscopic techniques to identify the molecular structure of the nanoparticles and their cargo.

"Raman and infrared spectroscopy are the two tools that one uses to see molecular structure," Bhargava said. "We think we coated this particle with a specific polymer and with specific drug-loading - but did we really? We use spectroscopy to confirm the formulation as well as visualize the delivery of the particles and drug molecules."

The team found that the nanoparticles did not release the drug payload at room temperature, but at body temperature began to release the anti-cancer drug. The researchers also determined which topical applications penetrated the skin to a desired depth.

In further experiments, the researchers found they could alter the infusion of the particles into melanoma cells by adjusting the polymer coatings. Imaging confirmed that the infused cells began to swell, a sign of impending cell death.

"This is a versatile platform to carry a multitude of drugs - for melanoma, for other kinds of cancers and for other diseases," Bhargava said. "You can coat it with different polymers to give it a different optical response. You can load it with two drugs, or three, or four, so you can do multidrug therapy with the same particles."

"By using defined surface chemistry, we can change the properties of these particles," Pan said. "We can make them glow at a certain wavelength and also we can tune them to release the drugs in the presence of the cellular environment. That is, I think, the beauty of the work."

###

The research team included faculty members in bioengineering, chemical and biomolecular engineering, chemistry, electrical and computer engineering and mechanical science and engineering; and researchers in the Illinois Sustainable Technology Center and the Materials Research Laboratory at Illinois. Pan and Bhargava are faculty members in the Beckman Institute for Advanced Science and Technology at Illinois, and are affiliated with Carle Foundation Hospital in Urbana, Illinois.

####

For more information, please click here

Contacts:
Diana Yates

217-333-5802

Dipanjan Pan
217-244-2938


Rohit Bhargava
217-265-6596

Copyright © University of Illinois at Urbana-Champaign

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The paper, "Tunable luminescent carbon nanospheres with well-defined nanoscale chemistry for synchronized imaging and therapy," is available online:

Related News Press

News and information

Intelligent optical chip to improve telecommunications: An INRS team uses autonomous learning approaches for optical waveform generators to boost optical signal processing functionalities for current and future telecom applications October 15th, 2021

Using quantum Parrondo’s random walks for encryption: Asst Prof Kang Hao Cheong and his research team from SUTD have set out to apply concepts from quantum Parrondo’s paradox in search of a working protocol for semiclassical encryption October 15th, 2021

Cellular environments shape molecular architecture: Researchers glean a more complete picture of a structure called the nuclear pore complex by studying it directly inside cells October 15th, 2021

How to program DNA robots to poke and prod cell membranes: A discovery of how to build little blocks out of DNA and get them to stick to lipids has implications for biosensing and mRNA vaccines October 15th, 2021

Molecular Sciences Software Institute receives $15 million grant from National Science Foundation October 15th, 2021

Imaging

Cellular environments shape molecular architecture: Researchers glean a more complete picture of a structure called the nuclear pore complex by studying it directly inside cells October 15th, 2021

Atomic-scale tailoring of graphene approaches macroscopic world June 18th, 2021

Chemistry

Molecular Sciences Software Institute receives $15 million grant from National Science Foundation October 15th, 2021

Inspired by photosynthesis, scientists double reaction quantum efficiency October 1st, 2021

Unprecedented view of a single catalyst nanoparticle at work: X-rays reveal compositional changes on active surface under reaction conditions October 1st, 2021

Researchers reveal multi-path mechanism in electrochemical CO2 reduction September 17th, 2021

Cancer

NYUAD study maps nanobody structure, leading to new ways to potentially fight diseases July 4th, 2021

Researchers turned transparent calcite into artificial gold June 11th, 2021

Turning the heat on: A flexible device for localized heat treatment of living tissues June 11th, 2021

Nanomedicine

Cellular environments shape molecular architecture: Researchers glean a more complete picture of a structure called the nuclear pore complex by studying it directly inside cells October 15th, 2021

How to program DNA robots to poke and prod cell membranes: A discovery of how to build little blocks out of DNA and get them to stick to lipids has implications for biosensing and mRNA vaccines October 15th, 2021

Directly into the brain: A 3D multifunctional and flexible neural interface: Novel design of brain chip implant allows for measuring neuronal activity while simultaneously delivering drugs to the implant site October 1st, 2021

New nano particles suppress resistance to cancer immunotherapy September 17th, 2021

Discoveries

Intelligent optical chip to improve telecommunications: An INRS team uses autonomous learning approaches for optical waveform generators to boost optical signal processing functionalities for current and future telecom applications October 15th, 2021

Using quantum Parrondo’s random walks for encryption: Asst Prof Kang Hao Cheong and his research team from SUTD have set out to apply concepts from quantum Parrondo’s paradox in search of a working protocol for semiclassical encryption October 15th, 2021

Cellular environments shape molecular architecture: Researchers glean a more complete picture of a structure called the nuclear pore complex by studying it directly inside cells October 15th, 2021

How to program DNA robots to poke and prod cell membranes: A discovery of how to build little blocks out of DNA and get them to stick to lipids has implications for biosensing and mRNA vaccines October 15th, 2021

Announcements

Using quantum Parrondo’s random walks for encryption: Asst Prof Kang Hao Cheong and his research team from SUTD have set out to apply concepts from quantum Parrondo’s paradox in search of a working protocol for semiclassical encryption October 15th, 2021

Cellular environments shape molecular architecture: Researchers glean a more complete picture of a structure called the nuclear pore complex by studying it directly inside cells October 15th, 2021

How to program DNA robots to poke and prod cell membranes: A discovery of how to build little blocks out of DNA and get them to stick to lipids has implications for biosensing and mRNA vaccines October 15th, 2021

Molecular Sciences Software Institute receives $15 million grant from National Science Foundation October 15th, 2021

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Intelligent optical chip to improve telecommunications: An INRS team uses autonomous learning approaches for optical waveform generators to boost optical signal processing functionalities for current and future telecom applications October 15th, 2021

Using quantum Parrondo’s random walks for encryption: Asst Prof Kang Hao Cheong and his research team from SUTD have set out to apply concepts from quantum Parrondo’s paradox in search of a working protocol for semiclassical encryption October 15th, 2021

Cellular environments shape molecular architecture: Researchers glean a more complete picture of a structure called the nuclear pore complex by studying it directly inside cells October 15th, 2021

How to program DNA robots to poke and prod cell membranes: A discovery of how to build little blocks out of DNA and get them to stick to lipids has implications for biosensing and mRNA vaccines October 15th, 2021

Research partnerships

A simple way to get complex semiconductors to assemble themselves: Much like crystallizing rock candy from sugar syrup, the new method grows 2D perovskites precisely layered with other 2D materials to produce crystals with a wide range of electronic properties September 17th, 2021

Lehigh University to lead ‘integrative partnerships’ for multi-university research collaboration in advanced optoelectronic material development: 5-year, $25 million NSF investment in IMOD, a revolutionary center for optoelectronic, quantum technologies September 10th, 2021

Tapping into magnets to clamp down on noise in quantum information September 9th, 2021

New molecular device has unprecedented reconfigurability reminiscent of brain plasticity: Device can be reconfigured multiple times simply by changing applied voltage September 3rd, 2021

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project