Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran

Abstract:
Iranian researchers used nanoparticles as quantum dots and presented a new, effective and sensitive method to study interaction between drug and DNA.

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran

Tehran, Iran | Posted on August 17th, 2014

Data obtained from this method can be used in the designing of anticancer drugs.

Studying the interaction between drugs and DNA is important for designing more effective anticancer drugs and for better understanding of biological processes such as gene translation and DNA chain transcription. In this research, the mechanism of fluorescent resonance energy transfer (FRET) from drug to nanoparticle (quantum dot) has resulted in the creation of a highly sensitive method to study interaction between drug and DNA.

Dr. Somayyeh Gholami, a graduate in analytical chemistry from Institute for Advanced Studies in Basic Sciences in Zanjan, explained about the research, and said "Taking into account the shining and appropriate optical stability of quantum dots, FRET sensitive and powerful method was designed in this research to quantitatively study the interaction between actinomycin anticancer drug and genome double strand. The results showed that the predicted hybridation equivalent coefficient for the formation of drug-DNA compound was in acceptable agreement with laboratorial data, and it confirmed a strong bond between the drug and the double strand."

"It must be pointed out that almost all the sequences related to four-strands are located at genome double strand zones. Therefore, the stability of DNA double strand or its combination with the drug can be considered a major limit for the formation of four-strands. In this study and by using an appropriate method and meaningful three dimensional data and using a powerful statistical method to analyze results, we succeeded in obtaining desirable information in this regard, which will be helpful in future studies in designing anticancer drugs," she added.

Results of the research have been published in Analytical and Bioanalytical Chemistry, vol. 405, issue 19, July 2013, pp. 6271-6280.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Carbon Sciences Developing Breakthrough Technology to Mass-Produce Graphene -- the New Miracle Material: Company Enters Into an Agreement With the University of California, Santa Barbara (UCSB) to Fund the Further Development of a New Graphene Process September 16th, 2014

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

Effective Nanotechnology Innovations to Receive Mustafa Prize September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Nanomedicine

Treatment of Cell Infection by Nanotechnology September 15th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

Iranian Scientists Discover Nanotechnology Method to Remove Limitations in Tumor Surgery September 11th, 2014

Iranian Nanotechnology Scientists Produce Polymeric Scaffolds for Tissue Engineering September 11th, 2014

Discoveries

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Simple, Cost-Effective Method Proposed for Synthesizing Zinc Oxide Nanopigments September 15th, 2014

Announcements

Carbon Sciences Developing Breakthrough Technology to Mass-Produce Graphene -- the New Miracle Material: Company Enters Into an Agreement With the University of California, Santa Barbara (UCSB) to Fund the Further Development of a New Graphene Process September 16th, 2014

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

Effective Nanotechnology Innovations to Receive Mustafa Prize September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Simple, Cost-Effective Method Proposed for Synthesizing Zinc Oxide Nanopigments September 15th, 2014

Quantum Dots/Rods

Nano-pea pod model widens electronics applications: A new theoretical model explains how a nanostructure, such as the nano-pea pod, can exhibit localised electrons September 4th, 2014

NANOPARTICLES INDIA August 8th, 2014

Researchers create quantum dots with single-atom precision June 30th, 2014

New Los Alamos Approach May Be Key to Quantum Dot Solar Cells With Real Gains in Efficiency: Nanoengineering Boosts Carrier Multiplication in Quantum Dots June 19th, 2014

Nanobiotechnology

NanoStruck has a High Recovery Rate on Mine Tailings: retrieval of up to 96% of Gold, 88% of Silver and 86% of Palladium September 12th, 2014

Boosting armor for nuclear-waste eating microbes September 12th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE