Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran

Abstract:
Iranian researchers used nanoparticles as quantum dots and presented a new, effective and sensitive method to study interaction between drug and DNA.

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran

Tehran, Iran | Posted on August 17th, 2014

Data obtained from this method can be used in the designing of anticancer drugs.

Studying the interaction between drugs and DNA is important for designing more effective anticancer drugs and for better understanding of biological processes such as gene translation and DNA chain transcription. In this research, the mechanism of fluorescent resonance energy transfer (FRET) from drug to nanoparticle (quantum dot) has resulted in the creation of a highly sensitive method to study interaction between drug and DNA.

Dr. Somayyeh Gholami, a graduate in analytical chemistry from Institute for Advanced Studies in Basic Sciences in Zanjan, explained about the research, and said "Taking into account the shining and appropriate optical stability of quantum dots, FRET sensitive and powerful method was designed in this research to quantitatively study the interaction between actinomycin anticancer drug and genome double strand. The results showed that the predicted hybridation equivalent coefficient for the formation of drug-DNA compound was in acceptable agreement with laboratorial data, and it confirmed a strong bond between the drug and the double strand."

"It must be pointed out that almost all the sequences related to four-strands are located at genome double strand zones. Therefore, the stability of DNA double strand or its combination with the drug can be considered a major limit for the formation of four-strands. In this study and by using an appropriate method and meaningful three dimensional data and using a powerful statistical method to analyze results, we succeeded in obtaining desirable information in this regard, which will be helpful in future studies in designing anticancer drugs," she added.

Results of the research have been published in Analytical and Bioanalytical Chemistry, vol. 405, issue 19, July 2013, pp. 6271-6280.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Making magnets flip like cats at room temperature: Heusler alloy NiMnSb could prove valuable as a new material for digital information processing and storage July 25th, 2016

An accelerated pipeline to open materials research: ORNL workflow system unites imaging, algorithms, and HPC to advance materials discovery and design July 24th, 2016

Russian physicists discover a new approach for building quantum computers: Physicists find a way of 'bundling together' multiple elements of a quantum computer July 24th, 2016

A 'smart dress' for oil-degrading bacteria July 24th, 2016

Nanomedicine

New remote-controlled microrobots for medical operations July 23rd, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

New probe developed for improved high resolution measurement of brain temperature: Improved accuracy could allow researchers to measure brain temperature in times of trauma when small deviations in temperature can lead to additional brain injury July 23rd, 2016

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Discoveries

Making magnets flip like cats at room temperature: Heusler alloy NiMnSb could prove valuable as a new material for digital information processing and storage July 25th, 2016

An accelerated pipeline to open materials research: ORNL workflow system unites imaging, algorithms, and HPC to advance materials discovery and design July 24th, 2016

Russian physicists discover a new approach for building quantum computers: Physicists find a way of 'bundling together' multiple elements of a quantum computer July 24th, 2016

A 'smart dress' for oil-degrading bacteria July 24th, 2016

Announcements

Making magnets flip like cats at room temperature: Heusler alloy NiMnSb could prove valuable as a new material for digital information processing and storage July 25th, 2016

An accelerated pipeline to open materials research: ORNL workflow system unites imaging, algorithms, and HPC to advance materials discovery and design July 24th, 2016

Russian physicists discover a new approach for building quantum computers: Physicists find a way of 'bundling together' multiple elements of a quantum computer July 24th, 2016

A 'smart dress' for oil-degrading bacteria July 24th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Making magnets flip like cats at room temperature: Heusler alloy NiMnSb could prove valuable as a new material for digital information processing and storage July 25th, 2016

An accelerated pipeline to open materials research: ORNL workflow system unites imaging, algorithms, and HPC to advance materials discovery and design July 24th, 2016

Russian physicists discover a new approach for building quantum computers: Physicists find a way of 'bundling together' multiple elements of a quantum computer July 24th, 2016

A 'smart dress' for oil-degrading bacteria July 24th, 2016

Quantum Dots/Rods

Researchers develop faster, precise silica coating process for quantum dot nanorods July 12th, 2016

Building a better bowtie: Bowtie-shaped nanostructures may advance the development of quantum devices WEIZMANN July 5th, 2016

A new form of hybrid photodetectors with quantum dots and graphene June 19th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanobiotechnology

New remote-controlled microrobots for medical operations July 23rd, 2016

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

New reaction for the synthesis of nanostructures July 21st, 2016

Research examines how to optimize nanoparticles for efficient drug delivery July 21st, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic