Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran

Abstract:
Iranian researchers used nanoparticles as quantum dots and presented a new, effective and sensitive method to study interaction between drug and DNA.

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran

Tehran, Iran | Posted on August 17th, 2014

Data obtained from this method can be used in the designing of anticancer drugs.

Studying the interaction between drugs and DNA is important for designing more effective anticancer drugs and for better understanding of biological processes such as gene translation and DNA chain transcription. In this research, the mechanism of fluorescent resonance energy transfer (FRET) from drug to nanoparticle (quantum dot) has resulted in the creation of a highly sensitive method to study interaction between drug and DNA.

Dr. Somayyeh Gholami, a graduate in analytical chemistry from Institute for Advanced Studies in Basic Sciences in Zanjan, explained about the research, and said "Taking into account the shining and appropriate optical stability of quantum dots, FRET sensitive and powerful method was designed in this research to quantitatively study the interaction between actinomycin anticancer drug and genome double strand. The results showed that the predicted hybridation equivalent coefficient for the formation of drug-DNA compound was in acceptable agreement with laboratorial data, and it confirmed a strong bond between the drug and the double strand."

"It must be pointed out that almost all the sequences related to four-strands are located at genome double strand zones. Therefore, the stability of DNA double strand or its combination with the drug can be considered a major limit for the formation of four-strands. In this study and by using an appropriate method and meaningful three dimensional data and using a powerful statistical method to analyze results, we succeeded in obtaining desirable information in this regard, which will be helpful in future studies in designing anticancer drugs," she added.

Results of the research have been published in Analytical and Bioanalytical Chemistry, vol. 405, issue 19, July 2013, pp. 6271-6280.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The Hydrogen-Fuel cell will revolutionize the economy of the world: New non-platinum and nanosized catalyst for polymer electrolyte fuel cell June 29th, 2015

June 29th, 2015

Efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising Results June 29th, 2015

Making new materials with micro-explosions: ANU media release: Scientists have made exotic new materials by creating laser-induced micro-explosions in silicon, the common computer chip material June 29th, 2015

Nanomedicine

Efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising Results June 29th, 2015

Chivalrous Knight Does Pro Bono June 27th, 2015

Green Chemistry Methods Used in Iran to Produce Zinc Oxide Nanoparticles June 27th, 2015

Targeted nanoparticles can overcome drug resistance in trypanosomes: A high-tech approach to combat sleeping sickness and potentially other neglected diseases June 26th, 2015

Discoveries

The Hydrogen-Fuel cell will revolutionize the economy of the world: New non-platinum and nanosized catalyst for polymer electrolyte fuel cell June 29th, 2015

June 29th, 2015

Efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising Results June 29th, 2015

Making new materials with micro-explosions: ANU media release: Scientists have made exotic new materials by creating laser-induced micro-explosions in silicon, the common computer chip material June 29th, 2015

Announcements

The Hydrogen-Fuel cell will revolutionize the economy of the world: New non-platinum and nanosized catalyst for polymer electrolyte fuel cell June 29th, 2015

June 29th, 2015

Efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising Results June 29th, 2015

Making new materials with micro-explosions: ANU media release: Scientists have made exotic new materials by creating laser-induced micro-explosions in silicon, the common computer chip material June 29th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

June 29th, 2015

Efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising Results June 29th, 2015

Making new materials with micro-explosions: ANU media release: Scientists have made exotic new materials by creating laser-induced micro-explosions in silicon, the common computer chip material June 29th, 2015

Helium 'balloons' offer new path to control complex materials June 27th, 2015

Quantum Dots/Rods

Biomanufacturing of CdS quantum dots: A bacterial method for the low-cost, environmentally-friendly synthesis of aqueous soluble quantum dot nanocrystals June 24th, 2015

Iranian Researchers Model, Design Optical Switches June 13th, 2015

Lehigh University researchers unveil engineering innovations at TechConnect 2015: TechConnect is the world's largest accelerator for industry-vetted emerging-technologies ready for commercialization June 11th, 2015

Investigation of Optical Properties of Quantum Dots in Presence of Magnetic, Electrical Fields June 10th, 2015

Nanobiotechnology

Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015

Newly-Developed Biosensor in Iran Detects Cocaine Addiction June 23rd, 2015

Researchers first to show that Saharan silver ants can control electromagnetic waves over an extremely broad range of the electromagnetic spectrum—findings may lead to biologically inspired coatings for passive radiative cooling of objects June 19th, 2015

Cellulose from wood can be printed in 3-D June 17th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project