Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > New imaging agent provides better picture of the gut

Abstract:
A multi-institutional team of researchers has developed a new nanoscale agent for imaging the gastrointestinal (GI) tract. This safe, noninvasive method for assessing the function and properties of the GI tract in real time could lead to better diagnosis and treatment of gut diseases.

New imaging agent provides better picture of the gut

Madison, WI | Posted on July 25th, 2014

Illnesses such as small bowel bacterial overgrowth, irritable bowel syndrome and inflammatory bowel disease all occur in the intestine and can lead to serious side effects in patients with diseases such as diabetes and Parkinson's.

Until now, there hasn't been a good way to functionally image the intestine. However, in a paper published on July 6 in the journal Nature Nanotechnology, the researchers demonstrated that through a complementary approach using photoacoustic imaging and positron emission tomography (PET), they have created a multimodal functional imaging agent that could be used to perform noninvasive functional imaging of the intestine in real time.

Weibo Cai — an associate professor of radiology, medical physics and biomedical engineering at the University of Wisconsin-Madison — worked collaboratively with Jonathan Lovell, an assistant professor of biomedical engineering at the State University of New York at Buffalo, and Chulhong Kim, an assistant professor of creative information technology engineering at Pohang University of Science and Technology in South Korea. The team developed a family of nanoparticles that can provide good optical contrast for imaging — yet avoid absorption into the body and withstand the harsh conditions of the stomach and intestine.

Currently, patients drink a chalky liquid called barium and technicians view the intestine through X-rays and ultrasound. These methods, however, have many limitations, including accessibility and the possibility of radiation exposure.

The researchers' nanoparticles contain bright dyes. Patients still will drink a liquid, but it will contain the nanoparticles and allow an imaging technician to noninvasively view the illuminated intestine with photoacoustic imaging. "We can actually see the movement of the intestine in real time," Lovell says.

Cai and Lovell worked collaboratively to use two imaging techniques. Cai specializes in PET imaging — which uses radioisotope-based tracers and is used in health care settings for noninvasive, whole-body imaging. Lovell and Kim's expertise is in photoacoustic imaging, a technique that draws on ultrasound to generate high-definition images through light-based imaging.

While photoacoustic techniques yield high-definition images, PET imaging can penetrate deeper and image the entire body. Combining the two delivers the most information possible: high-definition images, images deep inside the body and a view of the intestine in relation to the entire body.

So far, the researchers have conducted successful test trials in mice and are hoping to move to human trials soon. "This is one of the first studies using both imaging techniques," Cai says. "The two imaging techniques work well together and get us all of the information that we need."

Both Lovell and Cai are excited about what the new imaging agent might mean for patients. "We could potentially induce a paradigm shift that allows for much more routine examination of the intestine function," Lovell says. "That would really benefit overall health."

Cai hopes the imaging agent can be targeted to look for certain disease-related markers and be used in therapeutic applications in the near future. "It is everything I would hope for in an imaging agent, and it is safe since we use FDA-approved agents to make these nanoparticles. That is why I am so excited about this," he says. "These are the promising first steps."

###

Grants from the National Institutes of Health, the Department of Defense and the Korean Ministry of Science funded the research. Additional authors on the paper include Yumiao Zhang, Mansik Jeon, Laurie J. Rich, Hao Hong, Jumin Geng, Yin Zhang, Sixiang Shi, Todd E. Barnhart, Paschalis Alexandridis, Jan D. Huizinga and Mukund Seshadri.

####

For more information, please click here

Contacts:
Weibo Cai

608-262-1749

Jasmine Sola

Copyright © University of Wisconsin-Madison

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Imaging

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Bruker Introduces Second-Generation Inspire Nanochemical Imaging Solution: Featuring Unique PeakForce IR and IR EasyAlign Technology July 1st, 2015

News and information

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Bruker Introduces Second-Generation Inspire Nanochemical Imaging Solution: Featuring Unique PeakForce IR and IR EasyAlign Technology July 1st, 2015

GLOBALFOUNDRIES Completes Acquisition of IBM Microelectronics Business: Transaction adds differentiating technologies, world-class technologists, and intellectual property July 1st, 2015

Govt.-Legislation/Regulation/Funding/Policy

Influential Interfaces Lead to Advances in Organic Spintronics July 1st, 2015

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Proposed TSCA Nanomaterial Rule ‘Premature’, Says Former EPA Toxicologist July 1st, 2015

Nanomedicine

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015

Researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th, 2015

Discoveries

Influential Interfaces Lead to Advances in Organic Spintronics July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Emergence of a 'devil's staircase' in a spin-valve system July 1st, 2015

Measurement of Tiny Amounts of Heavy Metals in Baby Food Samples July 1st, 2015

Announcements

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Bruker Introduces Second-Generation Inspire Nanochemical Imaging Solution: Featuring Unique PeakForce IR and IR EasyAlign Technology July 1st, 2015

GLOBALFOUNDRIES Completes Acquisition of IBM Microelectronics Business: Transaction adds differentiating technologies, world-class technologists, and intellectual property July 1st, 2015

Samsung's New Graphene Technology Will Double Life Of Your Lithium-Ion Battery July 1st, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Influential Interfaces Lead to Advances in Organic Spintronics July 1st, 2015

Emergence of a 'devil's staircase' in a spin-valve system July 1st, 2015

Samsung's New Graphene Technology Will Double Life Of Your Lithium-Ion Battery July 1st, 2015

Measurement of Tiny Amounts of Heavy Metals in Baby Food Samples July 1st, 2015

Military

Graphene flexes its electronic muscles: Rice-led researchers calculate electrical properties of carbon cones, other shapes June 30th, 2015

The peaks and valleys of silicon: Team of USC Viterbi School of Engineering Researchers introduce new layered semiconducting materials as silicon alternative June 27th, 2015

Opening a new route to photonics Berkeley lab researchers find way to control light in densely packed nanowaveguides June 27th, 2015

World’s 1st Full-Color, Flexible, Skin-Like Display Developed at UCF June 24th, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

World’s 1st Full-Color, Flexible, Skin-Like Display Developed at UCF June 24th, 2015

Physicists fine-tune control of agile exotic materials: Tunable hybrid polaritons realized with graphene layer on hexagonal boron nitride June 24th, 2015

Robust new process forms 3-D shapes from flat sheets of graphene June 23rd, 2015

Lancaster University revolutionary quantum technology research receives funding boost June 22nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project