Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > New imaging agent provides better picture of the gut

Abstract:
A multi-institutional team of researchers has developed a new nanoscale agent for imaging the gastrointestinal (GI) tract. This safe, noninvasive method for assessing the function and properties of the GI tract in real time could lead to better diagnosis and treatment of gut diseases.

New imaging agent provides better picture of the gut

Madison, WI | Posted on July 25th, 2014

Illnesses such as small bowel bacterial overgrowth, irritable bowel syndrome and inflammatory bowel disease all occur in the intestine and can lead to serious side effects in patients with diseases such as diabetes and Parkinson's.

Until now, there hasn't been a good way to functionally image the intestine. However, in a paper published on July 6 in the journal Nature Nanotechnology, the researchers demonstrated that through a complementary approach using photoacoustic imaging and positron emission tomography (PET), they have created a multimodal functional imaging agent that could be used to perform noninvasive functional imaging of the intestine in real time.

Weibo Cai — an associate professor of radiology, medical physics and biomedical engineering at the University of Wisconsin-Madison — worked collaboratively with Jonathan Lovell, an assistant professor of biomedical engineering at the State University of New York at Buffalo, and Chulhong Kim, an assistant professor of creative information technology engineering at Pohang University of Science and Technology in South Korea. The team developed a family of nanoparticles that can provide good optical contrast for imaging — yet avoid absorption into the body and withstand the harsh conditions of the stomach and intestine.

Currently, patients drink a chalky liquid called barium and technicians view the intestine through X-rays and ultrasound. These methods, however, have many limitations, including accessibility and the possibility of radiation exposure.

The researchers' nanoparticles contain bright dyes. Patients still will drink a liquid, but it will contain the nanoparticles and allow an imaging technician to noninvasively view the illuminated intestine with photoacoustic imaging. "We can actually see the movement of the intestine in real time," Lovell says.

Cai and Lovell worked collaboratively to use two imaging techniques. Cai specializes in PET imaging — which uses radioisotope-based tracers and is used in health care settings for noninvasive, whole-body imaging. Lovell and Kim's expertise is in photoacoustic imaging, a technique that draws on ultrasound to generate high-definition images through light-based imaging.

While photoacoustic techniques yield high-definition images, PET imaging can penetrate deeper and image the entire body. Combining the two delivers the most information possible: high-definition images, images deep inside the body and a view of the intestine in relation to the entire body.

So far, the researchers have conducted successful test trials in mice and are hoping to move to human trials soon. "This is one of the first studies using both imaging techniques," Cai says. "The two imaging techniques work well together and get us all of the information that we need."

Both Lovell and Cai are excited about what the new imaging agent might mean for patients. "We could potentially induce a paradigm shift that allows for much more routine examination of the intestine function," Lovell says. "That would really benefit overall health."

Cai hopes the imaging agent can be targeted to look for certain disease-related markers and be used in therapeutic applications in the near future. "It is everything I would hope for in an imaging agent, and it is safe since we use FDA-approved agents to make these nanoparticles. That is why I am so excited about this," he says. "These are the promising first steps."

###

Grants from the National Institutes of Health, the Department of Defense and the Korean Ministry of Science funded the research. Additional authors on the paper include Yumiao Zhang, Mansik Jeon, Laurie J. Rich, Hao Hong, Jumin Geng, Yin Zhang, Sixiang Shi, Todd E. Barnhart, Paschalis Alexandridis, Jan D. Huizinga and Mukund Seshadri.

####

For more information, please click here

Contacts:
Weibo Cai

608-262-1749

Jasmine Sola

Copyright © University of Wisconsin-Madison

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanoparticles present sustainable way to grow food crops May 1st, 2016

Searching for a nanotech self-organizing principle May 1st, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Imaging

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

Bruker Introduces First of Its Kind Dimensional Analysis System: The Novel Contour CMM™ System Fully Integrates 3D Coordinate Measurements with Nanoscale Surface Height, Texture, Waviness and Form Characterization April 26th, 2016

Bruker Introduces Dimension FastScan Pro Industrial AFM: Providing Nanometer-Resolution at High Scan Rates for up to 300-mm Samples April 26th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

Nanomedicine

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Nanoparticles hold promise as double-edged sword against genital herpes April 28th, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Discoveries

Nanoparticles present sustainable way to grow food crops May 1st, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Announcements

Nanoparticles present sustainable way to grow food crops May 1st, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Nanoparticles present sustainable way to grow food crops May 1st, 2016

Searching for a nanotech self-organizing principle May 1st, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Personal cooling units on the horizon April 29th, 2016

Military

Nanograft seeded with 3 cell types promotes blood vessel formation to speed wound healing April 27th, 2016

The light stuff: A brand-new way to produce electron spin currents - Colorado State University physicists are the first to demonstrate using non-polarized light to produce a spin voltage in a metal April 26th, 2016

NRL reveals novel uniform coating process of p-ALD April 21st, 2016

Team builds first quantum cascade laser on silicon: Eliminates the need for an external light source for mid-infrared silicon photonic devices or photonic circuits April 21st, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Brookhaven's Oleg Gang Named a Battelle 'Inventor of the Year': Recognized for work using DNA to guide and regulate the self-assembly of nanoparticles into clusters and arrays with controllable properties April 25th, 2016

Zip software can detect the quantum-classical boundary: Compression of experimental data reveals the presence of quantum correlations April 21st, 2016

Making electronics out of coal: Instead of burning up this complex hydrocarbon, let's make devices from it April 20th, 2016

Nano-magnets produce 3-dimensional images: Wide-view 3-dimensional holographic display composed of nano-magnetic pixels April 20th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic