Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Production of Non-Virus Nanocarriers with Highest Amount of Gene Delivery

Abstract:
Iranian researchers from Tarbiat Modarres University changed the liposome production process and increased the amount of genes entrapped in the structure of these nanocarriers.

Production of Non-Virus Nanocarriers with Highest Amount of Gene Delivery

Tehran, Iran | Posted on July 17th, 2014

The non-virus nanocarriers have neutral structure and very high stability and they protect entrapped genes against degrading enzymes.

In this research, some changes were made in the synthesis of liposomes and nanocarriers were produced that can entrap DNA molecules with very high efficiency (98%) in their absolutely neutral structure. The results have so far been reported only for cationic liposomes that are highly toxic and can only be used in-vivo.

The nanostructure is very stable, to the extent that no release of DNA has been observed from it after six months. DNA is trapped in aqueous environment inside the liposome. Therefore, degrading enzymes are not able to degrade DNA molecule, and as a result, DNA has very high stability inside the structure.

Among other advantages of the designed nanocarrier, mention can be made of its very high ability in gene delivery to bacterium cell. Therefore, it can be used in the treatment of infections caused by bacteria, which are resistant to medications. The nanostructure can also be used as an appropriate carrier to delivery medications in the treatment of human diseases. The research team is currently carrying out studies on gene delivery to bacterium cells through this system.

Taking into account the obtained results, the researchers are hopeful that liposomes derived from cellular membrane will have important role in drug and gene delivery in the near future; therefore, they will take the place of toxic cationic carriers that are currently used.

Results of the research have been published in Molecular Biotechnology, vol. 55, issue 2, October 2013, pp. 120-130.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Nanoparticles could spur better LEDs, invisibility cloaks July 19th, 2017

Nanomedicine

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

'Upconverted' light has a bright future: Rice University professor developing plasmon-powered devices for medicine, security, solar cells July 17th, 2017

Researchers revolutionize vital conservation tool with use of gold nanotechnology and lasers: Cryopreservation study results have sweeping implications for wildlife conservation and human health July 15th, 2017

Nanomedicine opens door to precision medicine for brain tumors July 12th, 2017

Discoveries

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Here's a tip: Indented cement shows unique properties: Rice University models reveal nanoindentation can benefit crystals in concrete July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Announcements

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Here's a tip: Indented cement shows unique properties: Rice University models reveal nanoindentation can benefit crystals in concrete July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Here's a tip: Indented cement shows unique properties: Rice University models reveal nanoindentation can benefit crystals in concrete July 20th, 2017

Tokyo Institute of Technology research: Antiaromatic molecule displays record electrical conductance July 19th, 2017

Harnessing light to drive chemical reactions July 19th, 2017

Nanobiotechnology

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Researchers revolutionize vital conservation tool with use of gold nanotechnology and lasers: Cryopreservation study results have sweeping implications for wildlife conservation and human health July 15th, 2017

Nanomedicine opens door to precision medicine for brain tumors July 12th, 2017

Nature-inspired material uses liquid reinforcement: Rice U. nanoengineers create liquid-solid composites using clues from nature July 11th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project