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Home > Press > Tiny DNA pyramids enter bacteria easily -- and deliver a deadly payload

Abstract:
Bacterial infections usually announce themselves with pain and fever but often can be defeated with antibiotics — and then there are those that are sneaky and hard to beat. Now, scientists have built a new weapon against such pathogens in the form of tiny DNA pyramids. Published in the journal ACS Applied Materials & Interfaces, their study found the nanopyramids can flag bacteria and kill more of them than medicine alone.

Tiny DNA pyramids enter bacteria easily -- and deliver a deadly payload

Washington, DC | Posted on July 9th, 2014

David Leong, Jianping Xie and colleagues note that some infectious pathogens can lie in wait, undetectable in the human body or in places that antibiotics have a hard time accessing. Engineered nanomedicine offers a new way to deliver drugs directly into bacterial cells, but the carriers developed so far pose problems such as toxicity. So Leong's team decided to use DNA to build a better, safer drug-delivery tool.

They made little pyramids out of DNA that were so small that thousands could fit in the period at the end of this sentence. Then, they attached gold nanomaterials as fluorescent tags and also packaged the drug actinomycin D (AMD) into the struts of the DNA pyramids. In tests on the common bacteria Escherichia coli and Staphylococcus aureus, the scientists tracked the nanopyramids as they entered the cells and released the drug payload. This killed 65 percent of the S. aureus and 48 percent of the E. coli, compared to 42 percent and 14 percent with AMD alone.

The authors acknowledge funding from the Ministry of Education, Singapore.

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About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 161,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

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Contacts:
Michael Bernstein

202-872-6042

Jianping Xie, Ph.D.
Department of Chemical and Biomolecular Engineering
National University of Singapore
Singapore 117585
Phone: +65-65161067

or
David T. Leong, Ph.D.
Department of Chemical and Biomolecular Engineering
and NUS Graduate School for Integrative Science and Engineering
National University of Singapore
Singapore 117456
Phone: +65-65167262

Copyright © American Chemical Society

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