Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > UGA researchers use nanoparticles to enhance chemotherapy

Shanta Dhar (center), Rakesh Pathak (right) and Sean Marrache have developed a new formulation of cisplatin, a common chemotherapy drug, that significantly increases the drug's ability to target and destroy cancerous cells.
Shanta Dhar (center), Rakesh Pathak (right) and Sean Marrache have developed a new formulation of cisplatin, a common chemotherapy drug, that significantly increases the drug's ability to target and destroy cancerous cells.

Abstract:
University of Georgia researchers have developed a new formulation of cisplatin, a common chemotherapy drug, that significantly increases the drug's ability to target and destroy cancerous cells.

UGA researchers use nanoparticles to enhance chemotherapy

Athens, GA | Posted on July 8th, 2014

Cisplatin may be used to treat a variety of cancers, but it is most commonly prescribed for cancer of the bladder, ovaries, cervix, testicles and lung. It is an effective drug, but many cancerous cells develop resistance to the treatment.

Shanta Dhar, assistant professor of chemistry in the UGA Franklin College of Arts and Sciences, and Rakesh Pathak, a postdoctoral researcher in Dhar's lab, constructed a modified version of cisplatin called Platin-M, which is designed to overcome this resistance by attacking mitochondria within cancerous cells. They published their findings recently in the Proceedings of the National Academy of Sciences.

"You can think of mitochondria as a kind of powerhouse for the cell, generating the energy it needs to grow and reproduce," said Dhar, a member of the UGA Cancer Center and principal investigator for the project. "This prodrug delivers cisplatin directly to the mitochondria in cancerous cells. Without that essential powerhouse, the cell cannot survive."

Sean Marrache, a graduate student in Dhar's lab, entrapped Platin-M in a specially designed nanoparticle 1,000 times finer than a human hair that seeks out the mitochondria and releases the drug. Once inside, Platin-M interferes with the mitochondria's DNA, triggering cell death.

Dhar's research team tested Platin-M on neuroblastoma-a cancer commonly diagnosed in children-that typically originates in the adrenal glands. In preliminary experiments using a cisplatin-resistant cell culture, Platin-M nanoparticles were 17 times more active than cisplatin alone.

"This technique could become a treatment for a number of cancers, but it may prove most useful for more aggressive forms of cancer that are resistant to current therapies," said Pathak.

Both Dhar and Pathak caution that their experimental results are preliminary and they must do more work before Platin-M enters any clinical trials. However, their early results in mouse models are promising, and they are currently developing safety trials in larger animals.

"Cisplatin is a well-studied chemotherapy, so we hope our unique formulation will enhance its efficacy," said Dhar, who is also a member of UGA's Nanoscale Science and Engineering Center, Center for Drug Discovery, and Regenerative Bioscience Center. "We are excited about these early results, which look very promising."

This work was supported by an award from the National Institutes of Health, grant number P30GM092378, through the UGA Center of Metalloenzyme Studies and the UGA Office of the Vice President for Research.

####

For more information, please click here

Contacts:
Shanta Dhar

706-542-1012

Copyright © University of Georgia

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

For a full version of the article, see:

Related News Press

News and information

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Nanometrics Reports Second Quarter 2016 Financial Results July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

Govt.-Legislation/Regulation/Funding/Policy

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

Integration of novel materials with silicon chips makes new 'smart' devices possible July 25th, 2016

Nanomedicine

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

The NanoWizardŽ AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

Discoveries

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

The NanoWizardŽ AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Announcements

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Nanometrics Reports Second Quarter 2016 Financial Results July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

The NanoWizardŽ AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic