Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Artificial cilia: Scientists from Kiel University develop nano-structured transportation system

Artistic depiction of paramecia with artificial cilia: Chiral, unidirectional molecular switches mounted on surfaces are the prerequisite for inducing cilia driven directed motion. Scientists from Kiel transformed simple azobenzenes to chiral switches equipped with a molecular platform to mount them on gold surfaces. This bionic emulation of a billions of years old biological transportation system might be used in nano fabrication in the future. Illustration/Copyright: Herges
Artistic depiction of paramecia with artificial cilia: Chiral, unidirectional molecular switches mounted on surfaces are the prerequisite for inducing cilia driven directed motion. Scientists from Kiel transformed simple azobenzenes to chiral switches equipped with a molecular platform to mount them on gold surfaces. This bionic emulation of a billions of years old biological transportation system might be used in nano fabrication in the future.

Illustration/Copyright: Herges

Abstract:
Cilia, or ciliated epithelia, cover our respiratory tract like a lawn. In our pharynx and nasal mucosa they are responsible for continuously transporting mucus and particles embedded therein towards our throat. (except for heavy smokers, whose cilia where destroyed by nicotine and tar.) Tobias Tellkamp and Professor Rainer Herges have now come one step closer to their aim of artificially reproducing this biological transport system with switchable molecules.

Artificial cilia: Scientists from Kiel University develop nano-structured transportation system

Kiel, Germany | Posted on July 4th, 2014

Molecules that wiggle when exposed to light are known for a long time. But directed movement had not been possible up until now because back and forth movement cancel each other. To achieve a net displacement, the cilia should beat only to one side. Applying a trick within the molecular construction, the chemists of Kiel University's Collaborative Research Centre 677 "Function by Switching" solved this problem: Moreover, to get those molecular cilia up and running, the scientists fixed them on a surface. "We attached a kind of molecular suction cup onto the switches", project leader Herges explains.

Studies have shown that this suction cup adheres very well to gold surfaces. The team of scientists observed that the molecules self-assemble autonomously on the surface, densely packed, side by side like oranges on a shelf. "The suction cups adhere to the surface but they are still mobile and attract one another", explains doctoral candidate Tellkamp. In this way, an artificial epithelium is formed.

The next logical step is to find out if the artificial epithelium works much in the same way as our nasal mucosa. In collaboration with Prof. Olaf Magnussen in the Physics Department of Kiel University atomic force microscopy (AFM) will be used to visualize the light driven, directed transport of nanoscopic particles.

The recent findings are particularly interesting, not only with respect to fundamental research. With artificially ciliated epithelia, a molecular nano-fabrication seems possible - machines of molecular size would build other machines by positioning chemical products specifically and precisely. Entire production plants could thus fit onto a tiny chip. Other conceivable fields of application include artificial organelles equipped with molecular cilia that are controlled by an external stimulus; or in the more distant future, they could operate autonomously within the bloodstream and carry drugs to the site of a disease.

Full bibliographic information
Original publication
Tobias Tellkamp, Jun Shen, Yoshio Okamoto and Rainer Herges. Diazocines on Molecular Platforms. Eur. J. Org. Chem. 2014. DOI: 10.1002/ejoc.201402541 (Online Publication)

####

About Christian-Albrechts-Universitaet zu Kiel
When Duke Christian Albrecht of Holstein-Gottorp decided to found a university in 1665, the Thirty Years' War was over. The State required well-educated young men for service to government, who were to graduate from the new university. 140 students enrolled in the initially established faculties of Theology, Law, Medicine and Philosophy.

The University currently teaches over 24,000 women and men and the range of subjects on offer is spread over eight faculties. In addition to the original faculties, the faculties of Agricultural and Nutritional Science, Mathematics and Natural Sciences, Business, Economics and Social Sciences and, the newest faculty, the Faculty of Engineering are integrated into the university. Where once Max Planck and Heinrich Hertz worked, around 700 academics now pass on their knowledge to students from Germany and across the Globe.

For more information, please click here

Contacts:
Boris Pawlowski


Professor Rainer Herges
Kiel University
Otto Diels-Institute for Organic Chemistry
Phone: +49 (0)431/880-2440


Kiel University
Press, Communication and Marketing, Dr. Boris Pawlowski, editor: Denis Schimmelpfennig, translation: Ann-Christin Wimber
Address: D-24098 Kiel, Phone: +49 (0)431 880-2104, Telefax: +49 (0)431 880-1355
Internet: www.uni-kiel.de

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Synthetic Biology

In-cell molecular sieve from protein crystal February 14th, 2017

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Measuring forces in the DNA molecule: First direct measurements of base-pair bonding strength September 13th, 2016

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

Nanomedicine

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread: Leading-Edge Research Is Part of National Cancer Moonshot Initiative February 13th, 2017

Meta-lenses bring benchtop performance to small, hand-held spectrometer: Game-changing nanostructure-based lenses allow smaller devices, increased functionality February 9th, 2017

Discoveries

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Announcements

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Nanobiotechnology

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread: Leading-Edge Research Is Part of National Cancer Moonshot Initiative February 13th, 2017

Nanobiotix appoints senior executive from pharmaceutical industry, as Chief Operating Officer: Oncology industry veteran to oversee operations and product commercialization February 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project