Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Researchers use DNA to build tool that may literally shine light on cancer: Patented nanosensor detects and reacts to second pH changes in cells caused by cancer

Andrea Idili, Alexis Vallée-Bélisle and Francesco Ricci have developed a DNA-based nanosensor that allows to measure pH variation at the nanoscale. This nanosensor may significantly aid efforts to build nanodevices for cancer in-vivo imaging and targeted drug-delivery. This nanosensor measures less than 10 nm and unfolds at a specifically programmed pH.

Credit: Marco Tripodi
Andrea Idili, Alexis Vallée-Bélisle and Francesco Ricci have developed a DNA-based nanosensor that allows to measure pH variation at the nanoscale. This nanosensor may significantly aid efforts to build nanodevices for cancer in-vivo imaging and targeted drug-delivery. This nanosensor measures less than 10 nm and unfolds at a specifically programmed pH.

Credit: Marco Tripodi

Abstract:
Bioengineers at the University of Rome Tor Vergata and the University of Montreal have used DNA to develop a tool that detects and reacts to chemical changes caused by cancer cells and that may one day be used to deliver drugs to tumor cells.

Researchers use DNA to build tool that may literally shine light on cancer: Patented nanosensor detects and reacts to second pH changes in cells caused by cancer

Montreal, Canada | Posted on May 7th, 2014

The researchers' nanosensor measures pH variations at the nanoscale - how acidic (a higher pH level) or alkaline (a lower pH level) it is. Many biomolecules, such as enzymes and proteins, are strongly regulated by small pH changes. These changes affect in turn biological activities such as enzyme catalysis, protein assembly, membrane function and cell death. There is also a strong relation between cancer and pH.

Cancer cells often display a lower pH compared to normal cells: the pH level inside cancer cells is higher than it is outside. "In living organisms, these small pH changes typically occur in tiny areas measuring only few hundred nanometers," says senior author Prof. Francesco Ricci. "Developing sensors or nanomachines that can measure pH changes at this scale should prove of utility for several applications in the fields of in-vivo imaging, clinical diagnostics and drug-delivery."

"DNA represents an ideal material to build sensors or nanomachines at the nanometer scale" says senior author Prof. Vallée-Bélisle. "By taking advantage of a specific DNA sequences that form pH-sensitive triple helix, we have designed a versatile nanosensor that can be programmed to fluoresce only at specific pH values." Fluorescence is the emission of radiation, including visible light, caused by an exchange of energy. "This programming ability represents a key feature for clinical applications - we can design a specific sensor to send a fluorescent signal only when the pH reaches a specific value which is, for example, characteristic of a specific disease," adds first author Andrea Idili.

In the future, this recently patented nanotechnology may also find applications in the development of novel drug-delivery platforms that release chemio-therapeutic drugs only in the viscinity of tumor cells.

###

This research was supported by the European Research Council and the Natural Sciences and Engineering Research Council of Canada. Andrea Idili and Francesco Ricci at the Chemistry Department of the University of Rome, TorVergata, and Alexis Vallée-Bélisle of the University of Montreal's Department of Chemistry and Department of Biochemistry published "Programmable pH triggered DNA nanoswitches," in the Journal of American Chemical Society by. The University of Montreal is known officially as Université de Montréal.

####

For more information, please click here

Contacts:
William Raillant-Clark

514-566-3813

Copyright © University of Montreal

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Pixel-array quantum cascade detector paves the way for portable thermal imaging devices: Research team from TU-Wien Center for Micro- and Nanostructures have developed a new 'cooler' sensing instrument thereby increasing energy-efficiency and enhancing mobility for diagnostic tes July 28th, 2016

Dirty to drinkable: Engineers develop novel hybrid nanomaterials to transform water July 28th, 2016

Thomas Swan and NGI announce unique partnership July 28th, 2016

Penn team uses nanoparticles to break up plaque and prevent cavities July 28th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Thomas Swan and NGI announce unique partnership July 28th, 2016

Penn team uses nanoparticles to break up plaque and prevent cavities July 28th, 2016

Beating the heat a challenge at the nanoscale: Rice University scientists detect thermal boundary that hinders ultracold experiments July 28th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

Nanomedicine

Pixel-array quantum cascade detector paves the way for portable thermal imaging devices: Research team from TU-Wien Center for Micro- and Nanostructures have developed a new 'cooler' sensing instrument thereby increasing energy-efficiency and enhancing mobility for diagnostic tes July 28th, 2016

Starpharma initiates new DEP™ drug delivery program with AstraZeneca July 27th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Discoveries

Pixel-array quantum cascade detector paves the way for portable thermal imaging devices: Research team from TU-Wien Center for Micro- and Nanostructures have developed a new 'cooler' sensing instrument thereby increasing energy-efficiency and enhancing mobility for diagnostic tes July 28th, 2016

Dirty to drinkable: Engineers develop novel hybrid nanomaterials to transform water July 28th, 2016

Penn team uses nanoparticles to break up plaque and prevent cavities July 28th, 2016

Beating the heat a challenge at the nanoscale: Rice University scientists detect thermal boundary that hinders ultracold experiments July 28th, 2016

Announcements

Pixel-array quantum cascade detector paves the way for portable thermal imaging devices: Research team from TU-Wien Center for Micro- and Nanostructures have developed a new 'cooler' sensing instrument thereby increasing energy-efficiency and enhancing mobility for diagnostic tes July 28th, 2016

Dirty to drinkable: Engineers develop novel hybrid nanomaterials to transform water July 28th, 2016

Thomas Swan and NGI announce unique partnership July 28th, 2016

Penn team uses nanoparticles to break up plaque and prevent cavities July 28th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Dirty to drinkable: Engineers develop novel hybrid nanomaterials to transform water July 28th, 2016

Penn team uses nanoparticles to break up plaque and prevent cavities July 28th, 2016

Beating the heat a challenge at the nanoscale: Rice University scientists detect thermal boundary that hinders ultracold experiments July 28th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Nanobiotechnology

Starpharma initiates new DEP™ drug delivery program with AstraZeneca July 27th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New remote-controlled microrobots for medical operations July 23rd, 2016

Research partnerships

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

Rice's 'antenna-reactor' catalysts offer best of both worlds: Technology marries light-harvesting nanoantennas to high-reaction-rate catalysts July 18th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic