Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Iranian Chemists Build Smart Armored Nanocarriers

Abstract:
Iranian chemical researchers used nanotechnology to produce smart nanogels with active targeting capability.

Iranian Chemists Build Smart Armored Nanocarriers

Tehran, Iran | Posted on March 16th, 2014

Acid folic was used in the production of the nanogel as targeting agent in drug delivery. The nanogel can be used in the treatment of cancer as a stable nanocarrier.

Stability of nanocarriers is an important issue in target delivery mechanisms. Most of nanocarriers, due to their instability, release considerable amount of drug in healthy tissues before reaching the desired tissue, and they are free of drug when they reach the targeted tissue.

There are three different layers in the nanocarrier synthesized in this research: hydrophobic core made of polycaprolactone, which is filled with non-soluble or low-soluble anticancer drug in water, pH-sensitive layer made of amino ester, and finally the formation of nanogel and bond between targeting ligands such as folic acid and the hydrophilic shell made of polyethylene glycol as the stabilizing agent and the agent to prevent proteins existing in blood to accumulate on nanocarriers.

The middle layer formed in nanocarrier prevents its decomposition in thin aqueous media and plays the role of armor for the nanocarrier because of its networking ability and stabilization of copolymers. The amino ester structure of the layer possesses amine groups, and when they are protonized in acidic environment of the cancer cell, the structure causes repulsion among the chains of the layer, and it speeds up the release of the drug. Therefore, the nanocarriers are known as smart armored nanocarriers, and they will act highly effectively in the treatment of cancer after carrying out more research and passing in-vivo tests.

Results of the research have been published in details in European Journal of Medicinal Chemistry, vol. 73, issue 1, February 2014, pp. 18-29.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Light pulses control graphene's electrical behavior: Finding could allow ultrafast switching of conduction, and possibly lead to new broadband light sensors August 1st, 2014

President Obama Meets U.S. Laureates of 2014 Kavli Prizes August 1st, 2014

Stanford researchers seek 'Holy Grail' in battery design: Pure lithium anode closer to reality with development of protective layer of interconnected carbon domes August 1st, 2014

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

Chemistry

Nanostructured metal-oxide catalyst efficiently converts CO2 to methanol: Highly reactive sites at interface of 2 nanoscale components could help overcome hurdle of using CO2 as a starting point in producing useful products July 31st, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Iranian Scientists Use Waste Cotton Fibers to Produce Cellulose Nanoparticles July 29th, 2014

Nanomedicine

Taking the guesswork out of cancer therapy: New molecular test kit predicts patient’s survival and drug response August 1st, 2014

Arrowhead to Report Fiscal 2014 Third Quarter Financial Results- Conference Call Scheduled for Tuesday, August 12, 2014 - July 31st, 2014

New imaging agent provides better picture of the gut July 30th, 2014

Zenosense, Inc. July 29th, 2014

Discoveries

Iranian Scientists Produce Cobalt–Alumina Ceramic Nano Inks August 1st, 2014

Light pulses control graphene's electrical behavior: Finding could allow ultrafast switching of conduction, and possibly lead to new broadband light sensors August 1st, 2014

Taking the guesswork out of cancer therapy: New molecular test kit predicts patient’s survival and drug response August 1st, 2014

Carnegie Mellon Chemists Create Nanofibers Using Unprecedented New Method July 31st, 2014

Announcements

Light pulses control graphene's electrical behavior: Finding could allow ultrafast switching of conduction, and possibly lead to new broadband light sensors August 1st, 2014

President Obama Meets U.S. Laureates of 2014 Kavli Prizes August 1st, 2014

Stanford researchers seek 'Holy Grail' in battery design: Pure lithium anode closer to reality with development of protective layer of interconnected carbon domes August 1st, 2014

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

Iranian Scientists Produce Cobalt–Alumina Ceramic Nano Inks August 1st, 2014

Light pulses control graphene's electrical behavior: Finding could allow ultrafast switching of conduction, and possibly lead to new broadband light sensors August 1st, 2014

Stanford researchers seek 'Holy Grail' in battery design: Pure lithium anode closer to reality with development of protective layer of interconnected carbon domes August 1st, 2014

Taking the guesswork out of cancer therapy: New molecular test kit predicts patient’s survival and drug response August 1st, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE