Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Iranian Chemists Build Smart Armored Nanocarriers

Abstract:
Iranian chemical researchers used nanotechnology to produce smart nanogels with active targeting capability.

Iranian Chemists Build Smart Armored Nanocarriers

Tehran, Iran | Posted on March 16th, 2014

Acid folic was used in the production of the nanogel as targeting agent in drug delivery. The nanogel can be used in the treatment of cancer as a stable nanocarrier.

Stability of nanocarriers is an important issue in target delivery mechanisms. Most of nanocarriers, due to their instability, release considerable amount of drug in healthy tissues before reaching the desired tissue, and they are free of drug when they reach the targeted tissue.

There are three different layers in the nanocarrier synthesized in this research: hydrophobic core made of polycaprolactone, which is filled with non-soluble or low-soluble anticancer drug in water, pH-sensitive layer made of amino ester, and finally the formation of nanogel and bond between targeting ligands such as folic acid and the hydrophilic shell made of polyethylene glycol as the stabilizing agent and the agent to prevent proteins existing in blood to accumulate on nanocarriers.

The middle layer formed in nanocarrier prevents its decomposition in thin aqueous media and plays the role of armor for the nanocarrier because of its networking ability and stabilization of copolymers. The amino ester structure of the layer possesses amine groups, and when they are protonized in acidic environment of the cancer cell, the structure causes repulsion among the chains of the layer, and it speeds up the release of the drug. Therefore, the nanocarriers are known as smart armored nanocarriers, and they will act highly effectively in the treatment of cancer after carrying out more research and passing in-vivo tests.

Results of the research have been published in details in European Journal of Medicinal Chemistry, vol. 73, issue 1, February 2014, pp. 18-29.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Switching with molecules: Molecular switch will facilitate the development of pioneering electro-optical devices May 25th, 2018

Tunable diamond string may hold key to quantum memory: A process similar to guitar tuning improves storage time of quantum memory May 24th, 2018

Remote control of transport through nanopores: New study outlines key factors affecting the transfer of molecules through biological channels May 24th, 2018

2018 Kavli Prizes in Astrophysics, Nanoscience, and Neuroscience to be Announced Live on May 31: Live announcement at the Norwegian Academy of Science and Letters to be streamed live at World Science Festival Event May 24th, 2018

Chemistry

Magnesium magnificent for plasmonic applications: Rice University, University of Cambridge synthesize and test nanoparticles of abundant material May 22nd, 2018

A micro-thermometer to record tiny temperature changes May 15th, 2018

Team achieves two-electron chemical reactions using light energy, gold May 15th, 2018

Watching nanomaterials form in 4D: Novel technology allows researchers to see dynamic reactions as they happen at the nanoscale April 26th, 2018

Nanomedicine

Remote control of transport through nanopores: New study outlines key factors affecting the transfer of molecules through biological channels May 24th, 2018

New blood test rapidly detects signs of pancreatic cancer May 17th, 2018

Elastic microspheres expand understanding of embryonic development and cancer cells May 15th, 2018

Nanomedicine -- Targeting cancer cells with sugars May 14th, 2018

Discoveries

Switching with molecules: Molecular switch will facilitate the development of pioneering electro-optical devices May 25th, 2018

Tunable diamond string may hold key to quantum memory: A process similar to guitar tuning improves storage time of quantum memory May 24th, 2018

Remote control of transport through nanopores: New study outlines key factors affecting the transfer of molecules through biological channels May 24th, 2018

'Spooky action at a distance': Researchers develop module for quantum repeater May 23rd, 2018

Announcements

Switching with molecules: Molecular switch will facilitate the development of pioneering electro-optical devices May 25th, 2018

Tunable diamond string may hold key to quantum memory: A process similar to guitar tuning improves storage time of quantum memory May 24th, 2018

Remote control of transport through nanopores: New study outlines key factors affecting the transfer of molecules through biological channels May 24th, 2018

2018 Kavli Prizes in Astrophysics, Nanoscience, and Neuroscience to be Announced Live on May 31: Live announcement at the Norwegian Academy of Science and Letters to be streamed live at World Science Festival Event May 24th, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Switching with molecules: Molecular switch will facilitate the development of pioneering electro-optical devices May 25th, 2018

Tunable diamond string may hold key to quantum memory: A process similar to guitar tuning improves storage time of quantum memory May 24th, 2018

Remote control of transport through nanopores: New study outlines key factors affecting the transfer of molecules through biological channels May 24th, 2018

'Spooky action at a distance': Researchers develop module for quantum repeater May 23rd, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project