Home > Press > Iranian Chemists Build Smart Armored Nanocarriers
Abstract:
Iranian chemical researchers used nanotechnology to produce smart nanogels with active targeting capability.
Acid folic was used in the production of the nanogel as targeting agent in drug delivery. The nanogel can be used in the treatment of cancer as a stable nanocarrier.
Stability of nanocarriers is an important issue in target delivery mechanisms. Most of nanocarriers, due to their instability, release considerable amount of drug in healthy tissues before reaching the desired tissue, and they are free of drug when they reach the targeted tissue.
There are three different layers in the nanocarrier synthesized in this research: hydrophobic core made of polycaprolactone, which is filled with non-soluble or low-soluble anticancer drug in water, pH-sensitive layer made of amino ester, and finally the formation of nanogel and bond between targeting ligands such as folic acid and the hydrophilic shell made of polyethylene glycol as the stabilizing agent and the agent to prevent proteins existing in blood to accumulate on nanocarriers.
The middle layer formed in nanocarrier prevents its decomposition in thin aqueous media and plays the role of armor for the nanocarrier because of its networking ability and stabilization of copolymers. The amino ester structure of the layer possesses amine groups, and when they are protonized in acidic environment of the cancer cell, the structure causes repulsion among the chains of the layer, and it speeds up the release of the drug. Therefore, the nanocarriers are known as smart armored nanocarriers, and they will act highly effectively in the treatment of cancer after carrying out more research and passing in-vivo tests.
Results of the research have been published in details in European Journal of Medicinal Chemistry, vol. 73, issue 1, February 2014, pp. 18-29.
####
For more information, please click here
Copyright © Fars News Agency
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related News Press |
News and information
Simulating magnetization in a Heisenberg quantum spin chain April 5th, 2024
NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
Chemistry
What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024
Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024
Nanomedicine
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Good as gold - improving infectious disease testing with gold nanoparticles April 5th, 2024
Researchers develop artificial building blocks of life March 8th, 2024
Discoveries
Chemical reactions can scramble quantum information as well as black holes April 5th, 2024
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Utilizing palladium for addressing contact issues of buried oxide thin film transistors April 5th, 2024
Announcements
NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters
Simulating magnetization in a Heisenberg quantum spin chain April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
The latest news from around the world, FREE | ||
Premium Products | ||
Only the news you want to read!
Learn More |
||
Full-service, expert consulting
Learn More |
||