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The newly-fabricated nanofiber mesh for the removal of toxins from the blood, made by WPI-MANA researchers, may be incorporated into wearable blood purification systems for kidney failure patients.

Abstract:
A simple way to treat kidney failure. A new technique for purifying blood using a nanofiber mesh could prove useful as a cheap, wearable alternative to kidney dialysis.

MANA Research Highlight: Smart nanofibers to treat kidney failure

Tsukuba, Japan | Posted on March 6th, 2014

The newly-fabricated nanofiber mesh for the removal of toxins from the blood, made by WPI-MANA researchers, may be incorporated into wearable blood purification systems for kidney failure patients.

Kidney failure results in a build up of toxins and excess waste in the body. Dialysis is the most common treatment, performed daily either at home or in hospital. However, dialysis machines require electricity and careful maintenance, and are therefore more readily available in developed countries than poorer nations. Around one million people die each year worldwide from potentially preventable end-stage renal disease.

In addition to this, in the aftermath of disasters such as the Japanese earthquake and tsunami of 2011, dialysis patients are frequently left without treatment until normal hospital services are resumed. With this in mind, Mitsuhiro Ebara and co-workers at the International Center for Materials Nanoarchitectonics, National Institute for Materials Science in Ibaraki, Japan, have developed a way of removing toxins and waste from blood using a cheap, easy-to-produce nanofiber mesh1. The mesh could be incorporated into a blood purification product small enough to be worn on a patient's arm, reducing the need for expensive, time-consuming dialysis.

The team made their nanofiber mesh using two components: a blood-compatible primary matrix polymer made from polyethylene-co-vinyl alchohol, or EVOH, and several different forms of zeolites - naturally occurring aluminosilicates. Zeolites have microporous structures capable of adsorbing toxins such as creatinine from blood.

The researchers generated the mesh using a versatile and cost-effective process called electrospinning - using an electrical charge to draw fibers from a liquid. Ebara and his team found that the silicon-aluminum ratio within the zeolites is critical to creatinine adsorption. Beta type 940-HOA zeolite had the highest capacity for toxin adsorption, and shows potential for a final blood purification product.

Although the new design is still in its early stages and not yet ready for production, Ebara and his team are confident that a product based on their nanofiber mesh will soon be a feasible, compact and cheap alternative to dialysis for kidney failure patients across the world.

Reference

1. K. Namekawa, M.T. Schreiber, T. Aoyagi, & M. Ebara. Fabrication of zeolite-polymer composite nanofibers for removal of uremic toxins from kidney failure patients. Biomaterials Science (2014)

doi: 10.1039/c3bm60263j

Affiliations

The researchers on this project are associated with the following institution:

International Center for Materials Nanoarchitechtonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan

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About International Center of Materials Nanoarchitectonics (MANA)
The International Center for Materials Nanoarchitectonics (MANA) was one of the five research centers selected by Japan's Ministry of Education, Culture, Sports, Science and Technology (MEXT) for the World Premier International (WPI) Research Center Initiative in 2007. The aim of the WPI is to create new world-class research facilities sufficiently attractive to prompt outstanding researchers from around the world to want to work in them, and MANA was established under this premise to encourage proactive science and technology research with a team of excellent researchers. MANA has been called one of Japan's best research institutes not only for its research output, but also for its efforts to internationalize and establish effective programs for training young researchers.

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Contacts:
International Center of Materials Nanoarchitectonics (MANA)
National Institute for Materials Science
1-1 Namiki Tsukuba, Ibaraki 305-0044 JAPAN
Phone: +81-29-860-4710
mana-pr[AT]ml.nims.go.jp
http://www.nims.go.jp/mana/

Publisher
International Center for Materials Nanoarchitectonics (WPI-MANA)
Address: 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
URL: http://www.nims.go.jp/mana/

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