Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > UC research tests which nano system works best in killing cancer cells: New UC research to be presented this week tested four iron-oxide nanoparticle systems to see which, when heated, would likely work best as a tool for targeting cancer cells

View of iron-oxide nanoparticles embedded in a polystyrene matrix as seen via a transmission electron microscope. These nanoparticles, when heated, can be applied to cancer cells in order to kill those cells.
View of iron-oxide nanoparticles embedded in a polystyrene matrix as seen via a transmission electron microscope. These nanoparticles, when heated, can be applied to cancer cells in order to kill those cells.

Abstract:
In current research related to improving cancer treatments, one promising area of research is the effort to find ways to selectively pinpoint and target cancer cells while minimizing effects on healthy cells.

UC research tests which nano system works best in killing cancer cells: New UC research to be presented this week tested four iron-oxide nanoparticle systems to see which, when heated, would likely work best as a tool for targeting cancer cells

Cincinnati, OH | Posted on March 4th, 2014

In that effort, it's already been found in lab experiments that iron-oxide nanoparticles, when heated and then applied specifically to cancer cells, can kill those cells because cancer cells are particularly susceptible to changes in temperature. Increasing the temperature of cancer cells to over 43 degrees Celsius (about 109 degrees Fahrenheit) for a sufficient period of time can kill those cells.

So, a University of Cincinnati-led team - along with researchers at Iowa State University, the University of Michigan and Shanghai Jiao Tong University - recently conducted experiments to see which iron-oxide nanoparticle configurations or arrangements might work best as a tool to deliver this killing heat directly to cancer cells, specifically to breast cancer cells. The results will be presented at the March 3-7 American Physical Society Conference in Denver by UC physics doctoral student Md Ehsan Sadat.

In systematically studying four distinct magnetized nanoparticle systems with different structural and magnetic properties, the research team found that an unconfined nanoparticle system, which used an electromagnetic field to generate heat, was best able to transfer heat absorbed by cancer cells.

So, from the set of nano systems studied, the researchers found that uncoated iron-oxide nanoparticles and iron-oxide nanoparticles coated with polyacrylic acid (PAA) - both of which were unconfined or not embedded in a matrix - heated quickly and to temperatures more than sufficient to kill cancer cells.
Uncoated iron-oxide nanoparticles increased from a room temperature of 22 degrees Celsius to 66 degrees Celsius (about 150 degrees Fahrenheit).

Iron-oxide nanoparticles coated with polyacrylic acid (PAA) heated from a room temperature of 22 degrees Celsius to 73 degrees Celsius (about 163 degrees Fahrenheit.)

The goal was to determine the heating behaviors of different iron-oxide nanoparticles that varied in terms of the materials used in the nanoparticle apparatus as well as particle size, particle geometry, inter-particle spacing, physical confinement and surrounding environment since these are the key factors that strongly influence what's called the Specific Absorption Rate (SAR), or the measured rate at which the human body can absorb energy (in this case heat) when exposed to an electromagnetic field.

According to Sadat, "What we found was that the size of the particles and their anisotropic (directional) properties strongly affected the magnetic heating achieved. In other words, the smaller the particles and the greater their directional uniformity along an axis, the greater the heating that was achieved."

He added the systems' heating behaviors were also influenced by the concentrations of nanoparticles present. The higher the concentration of nanoparticles (the greater the number of nanoparticles and the more densely collected), the lower the SAR or the rate at which the tissue was able to absorb the heat generated.

THE FOUR SYSTEMS STUDIED
The researchers studied
uncoated iron-oxide nanoparticles
iron-oxide nanoparticles coated with polyacrylic acid (PAA)
a polystyrene nanosphere with iron-oxide nanoparticles uniformly embedded in its matrix
a polystyrene nanosphere with iron-oxide nanoparticles uniformly embedded in its matrix but with a thin film surface of silica

All four nanoparticle systems were exposed to the same magnetic field for 35 minutes, and temperature measurements were performed at two-minute intervals.

As stated, the PAA iron-oxide and the uncoated iron-oxide samples showed the highest temperature change. The lowest temperature changes, insufficient to kill cancer cells, were exhibited by
The polystyrene nanosphere, which heated to 36 degrees Celsius (about 96 degree Fahrenheit).
The polystyrene nanosphere with a silica coating heated to 40 degrees Celsius (104 degrees Fahrenheit).

In addition to Sadat, others on the research team include Ronak Patel, former master's student in materials sciences and engineering in UC's College of Engineering and Applied Science; Jason Sookoor, undergraduate neuroscience student from UC's McMicken College of Arts and Sciences; Sergey L. Bud'ko, adjunct associate professor, Ames Laboratory and Department of Physics and Astronomy, Iowa State University; Rodney C. Ewing, Edward H. Kraus distinguished university professor, University of Michigan; Jiaming Zhang, assistant research scientist, University of Michigan; Hong Xu of the Med-X Institute, Shanghai Jiao Tong University; Giovanni M. Pauletti, associate professor in UC's James L. Winkle College of Pharmacy; David B. Mast, associate professor of physics in UC's McMicken College of Arts and Sciences; and Donglu Shi, professor of materials science and engineering at UC's College of Engineering and Applied Science.

Support for this research was provided by a National Science Foundation grant under contract number NSF (1343568) titled "Development of Nanotechnology Minor Focused on Nano Biomedicine and Sustainable Energy." Work at the Ames Laboratory was supported by the United States Department of Energy, Basic Energy Sciences, Division of Materials Sciences and Engineering.

####

For more information, please click here

Contacts:
M.B. Reilly

513-556-1824

Copyright © University of Cincinnati

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Oxford Instruments announces Dr Kate Ross as winner of the 2018 Lee Osheroff Richardson Science Prize for North and South America February 20th, 2018

Computers aid discovery of new, inexpensive material to make LEDs with high color quality February 20th, 2018

Unconventional superconductor may be used to create quantum computers of the future: They have probably succeeded in creating a topological superconductor February 19th, 2018

Photonic chip guides single photons, even when there are bends in the road February 16th, 2018

Laboratories

Atomic Flaws Create Surprising, High-Efficiency UV LED Materials: Subtle surface defects increase UV light emission in greener, more cost-effective LED and catalyst materials February 8th, 2018

Thanks for the memory: NIST takes a deep look at memristors January 20th, 2018

Laboratory Management Web Application Goes Nationwide January 9th, 2018

NRL improves optical efficiency in nanophotonic devices January 4th, 2018

Govt.-Legislation/Regulation/Funding/Policy

Computers aid discovery of new, inexpensive material to make LEDs with high color quality February 20th, 2018

Arrowhead Receives Regulatory Clearance to Begin Phase 1/2 Study of ARO-HBV for Treatment of Hepatitis B February 15th, 2018

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-AAT February 15th, 2018

Rutgers-Led Innovation Could Spur Faster, Cheaper, Nano-Based Manufacturing: Scalable and cost-effective manufacturing of thin film devices February 14th, 2018

Nanomedicine

Arrowhead Receives Regulatory Clearance to Begin Phase 1/2 Study of ARO-HBV for Treatment of Hepatitis B February 15th, 2018

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-AAT February 15th, 2018

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers February 15th, 2018

Understanding brain functions using upconversion nanoparticles: Researchers can now send light deep into the brain to study neural activities February 14th, 2018

Discoveries

Computers aid discovery of new, inexpensive material to make LEDs with high color quality February 20th, 2018

Unconventional superconductor may be used to create quantum computers of the future: They have probably succeeded in creating a topological superconductor February 19th, 2018

Photonic chip guides single photons, even when there are bends in the road February 16th, 2018

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers February 15th, 2018

Announcements

Oxford Instruments announces Dr Kate Ross as winner of the 2018 Lee Osheroff Richardson Science Prize for North and South America February 20th, 2018

Computers aid discovery of new, inexpensive material to make LEDs with high color quality February 20th, 2018

Unconventional superconductor may be used to create quantum computers of the future: They have probably succeeded in creating a topological superconductor February 19th, 2018

Photonic chip guides single photons, even when there are bends in the road February 16th, 2018

Events/Classes

European & Korean Project To Demo World’s First 5G Platform During Winter Games February 15th, 2018

Leti’s Chief Scientist Presents Optimistic Vision for Neuromorphic Hardware and Ultra-Low-Power Microdevices for Edge Computing at ISSCC: Leti’s Chief Scientist Presents Optimistic Vision for Neuromorphic Hardware and Ultra-Low-Power Microdevices That Are Based on Novel Emerging February 13th, 2018

Leti Chief Scientist Barbara De Salvo Will Help Kick Off ISSCC 2018 with Opening-Day Keynote: In Addition, Leti Scientists Will Present and Demo New Technology for Piezoelectric Energy Harvesting February 8th, 2018

Leti Presents Optical-Equipment Curving Technology that Improves Performance, Cuts Costs: ‘Disruptive Approach’ for Imaging Applications Presented in Paper At Photonics West and Demonstrated in Leti’s Booth February 2nd, 2018

Research partnerships

Computers aid discovery of new, inexpensive material to make LEDs with high color quality February 20th, 2018

Rutgers-Led Innovation Could Spur Faster, Cheaper, Nano-Based Manufacturing: Scalable and cost-effective manufacturing of thin film devices February 14th, 2018

Understanding brain functions using upconversion nanoparticles: Researchers can now send light deep into the brain to study neural activities February 14th, 2018

Vanadium dioxyde: A revolutionary material for tomorrow's electronics: Phase-chance switch can now be performed at higher temperatures February 5th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project