Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > UC research tests which nano system works best in killing cancer cells: New UC research to be presented this week tested four iron-oxide nanoparticle systems to see which, when heated, would likely work best as a tool for targeting cancer cells

View of iron-oxide nanoparticles embedded in a polystyrene matrix as seen via a transmission electron microscope. These nanoparticles, when heated, can be applied to cancer cells in order to kill those cells.
View of iron-oxide nanoparticles embedded in a polystyrene matrix as seen via a transmission electron microscope. These nanoparticles, when heated, can be applied to cancer cells in order to kill those cells.

Abstract:
In current research related to improving cancer treatments, one promising area of research is the effort to find ways to selectively pinpoint and target cancer cells while minimizing effects on healthy cells.

UC research tests which nano system works best in killing cancer cells: New UC research to be presented this week tested four iron-oxide nanoparticle systems to see which, when heated, would likely work best as a tool for targeting cancer cells

Cincinnati, OH | Posted on March 4th, 2014

In that effort, it's already been found in lab experiments that iron-oxide nanoparticles, when heated and then applied specifically to cancer cells, can kill those cells because cancer cells are particularly susceptible to changes in temperature. Increasing the temperature of cancer cells to over 43 degrees Celsius (about 109 degrees Fahrenheit) for a sufficient period of time can kill those cells.

So, a University of Cincinnati-led team - along with researchers at Iowa State University, the University of Michigan and Shanghai Jiao Tong University - recently conducted experiments to see which iron-oxide nanoparticle configurations or arrangements might work best as a tool to deliver this killing heat directly to cancer cells, specifically to breast cancer cells. The results will be presented at the March 3-7 American Physical Society Conference in Denver by UC physics doctoral student Md Ehsan Sadat.

In systematically studying four distinct magnetized nanoparticle systems with different structural and magnetic properties, the research team found that an unconfined nanoparticle system, which used an electromagnetic field to generate heat, was best able to transfer heat absorbed by cancer cells.

So, from the set of nano systems studied, the researchers found that uncoated iron-oxide nanoparticles and iron-oxide nanoparticles coated with polyacrylic acid (PAA) - both of which were unconfined or not embedded in a matrix - heated quickly and to temperatures more than sufficient to kill cancer cells.
Uncoated iron-oxide nanoparticles increased from a room temperature of 22 degrees Celsius to 66 degrees Celsius (about 150 degrees Fahrenheit).

Iron-oxide nanoparticles coated with polyacrylic acid (PAA) heated from a room temperature of 22 degrees Celsius to 73 degrees Celsius (about 163 degrees Fahrenheit.)

The goal was to determine the heating behaviors of different iron-oxide nanoparticles that varied in terms of the materials used in the nanoparticle apparatus as well as particle size, particle geometry, inter-particle spacing, physical confinement and surrounding environment since these are the key factors that strongly influence what's called the Specific Absorption Rate (SAR), or the measured rate at which the human body can absorb energy (in this case heat) when exposed to an electromagnetic field.

According to Sadat, "What we found was that the size of the particles and their anisotropic (directional) properties strongly affected the magnetic heating achieved. In other words, the smaller the particles and the greater their directional uniformity along an axis, the greater the heating that was achieved."

He added the systems' heating behaviors were also influenced by the concentrations of nanoparticles present. The higher the concentration of nanoparticles (the greater the number of nanoparticles and the more densely collected), the lower the SAR or the rate at which the tissue was able to absorb the heat generated.

THE FOUR SYSTEMS STUDIED
The researchers studied
uncoated iron-oxide nanoparticles
iron-oxide nanoparticles coated with polyacrylic acid (PAA)
a polystyrene nanosphere with iron-oxide nanoparticles uniformly embedded in its matrix
a polystyrene nanosphere with iron-oxide nanoparticles uniformly embedded in its matrix but with a thin film surface of silica

All four nanoparticle systems were exposed to the same magnetic field for 35 minutes, and temperature measurements were performed at two-minute intervals.

As stated, the PAA iron-oxide and the uncoated iron-oxide samples showed the highest temperature change. The lowest temperature changes, insufficient to kill cancer cells, were exhibited by
The polystyrene nanosphere, which heated to 36 degrees Celsius (about 96 degree Fahrenheit).
The polystyrene nanosphere with a silica coating heated to 40 degrees Celsius (104 degrees Fahrenheit).

In addition to Sadat, others on the research team include Ronak Patel, former master's student in materials sciences and engineering in UC's College of Engineering and Applied Science; Jason Sookoor, undergraduate neuroscience student from UC's McMicken College of Arts and Sciences; Sergey L. Bud'ko, adjunct associate professor, Ames Laboratory and Department of Physics and Astronomy, Iowa State University; Rodney C. Ewing, Edward H. Kraus distinguished university professor, University of Michigan; Jiaming Zhang, assistant research scientist, University of Michigan; Hong Xu of the Med-X Institute, Shanghai Jiao Tong University; Giovanni M. Pauletti, associate professor in UC's James L. Winkle College of Pharmacy; David B. Mast, associate professor of physics in UC's McMicken College of Arts and Sciences; and Donglu Shi, professor of materials science and engineering at UC's College of Engineering and Applied Science.

Support for this research was provided by a National Science Foundation grant under contract number NSF (1343568) titled "Development of Nanotechnology Minor Focused on Nano Biomedicine and Sustainable Energy." Work at the Ames Laboratory was supported by the United States Department of Energy, Basic Energy Sciences, Division of Materials Sciences and Engineering.

####

For more information, please click here

Contacts:
M.B. Reilly

513-556-1824

Copyright © University of Cincinnati

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

Leti to Demo 1st Wireless UNB Transceiver for ‘Massive Internet of Things’ at RFIC 2017 and IMS 2017: Leti Will also Present Three Papers & Two Workshops on 5G Communications IC Design, from RF to mm-Wave, During IMS 2017 and RFIC 2017 in Hawaii May 24th, 2017

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Laboratories

NREL’s Advanced Atomic Layer Deposition Enables Lithium-Ion Battery Technology: May 10th, 2017

Discovery of new transparent thin film material could improve electronics and solar cells: Conductivity is highest-ever for thin film oxide semiconductor material May 6th, 2017

Sandia develops math techniques to improve computational efficiency in quantum chemistry May 5th, 2017

Scientists Set Record Resolution for Drawing at the One-Nanometer Length Scale: An electron microscope-based lithography system for patterning materials at sizes as small as a single nanometer could be used to create and study materials with new properties May 1st, 2017

Govt.-Legislation/Regulation/Funding/Policy

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Graphene-nanotube hybrid boosts lithium metal batteries: Rice University prototypes store 3 times the energy of lithium-ion batteries May 19th, 2017

Stanford scientists use nanotechnology to boost the performance of key industrial catalyst May 18th, 2017

Oddball enzyme provides easy path to synthetic biomaterials May 17th, 2017

Nanomedicine

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Oddball enzyme provides easy path to synthetic biomaterials May 17th, 2017

The brighter side of twisted polymers: Conjugated polymers designed with a twist produce tiny, brightly fluorescent particles with broad applications May 16th, 2017

Discoveries

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Graphene-nanotube hybrid boosts lithium metal batteries: Rice University prototypes store 3 times the energy of lithium-ion batteries May 19th, 2017

Announcements

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

Leti to Demo 1st Wireless UNB Transceiver for ‘Massive Internet of Things’ at RFIC 2017 and IMS 2017: Leti Will also Present Three Papers & Two Workshops on 5G Communications IC Design, from RF to mm-Wave, During IMS 2017 and RFIC 2017 in Hawaii May 24th, 2017

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Events/Classes

Leti to Demo 1st Wireless UNB Transceiver for ‘Massive Internet of Things’ at RFIC 2017 and IMS 2017: Leti Will also Present Three Papers & Two Workshops on 5G Communications IC Design, from RF to mm-Wave, During IMS 2017 and RFIC 2017 in Hawaii May 24th, 2017

Leti Will Demo World’s-first WVGA 10-µm Pitch GaN Microdisplays for Augmented Reality Video at Display Week in Los Angles: Invited Paper also Will Present Leti’s Success with New Augmented Reality Technology That Reduces Pixel Pitch to Less than 5 Microns May 22nd, 2017

Oxford Instruments Asylum Research and Microscopy and Analysis Present the Webinar: “Video-Rate Atomic Force Microscopy Enables New Research Opportunities” May 9th, 2017

Graphene flagship steers towards higher technology readiness level May 4th, 2017

Research partnerships

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Stanford scientists use nanotechnology to boost the performance of key industrial catalyst May 18th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project