Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Researchers create coating material to prevent blood clots associated with implanted devices

Abstract:
A team of researchers from UCLA and the University of Michigan has developed a material that could help prevent blood clots associated with catheters, heart valves, vascular grafts and other implanted biomedical devices.

Researchers create coating material to prevent blood clots associated with implanted devices

Los Angeles, CA | Posted on March 1st, 2014

Blood clots at or near implanted devices are thought to occur when the flow of nitric oxide, a naturally occurring clot-preventing agent generated in the blood vessels, is cut off. When this occurs, the devices can fail.

Some researchers have sought to solve this problem with implantable devices that gradually release nitric oxide, but their supply of the agent is necessarily limited. Instead, the UCLA-Michigan team focused on an ultra-thin coating for the devices that acts as a chemical catalyst, generating clot-preventing molecules that can mimic the function of blood vessels.

The researchers suggest this could offer a long-lasting and cost-effective solution to the problem of these blood clots. The study was published online this month in the journal Nature Communications.

For the device coating, the team used sheets of graphene, a one-atom-thick layer of graphitic carbon, into which they integrated two components haemin and glucose oxidase. Both work synergistically to catalyze the production of nitroxyl, which can be used inside the blood like nitric oxide, although it contains one less electron. Nitroxyl has been reported as being analogous to nitric oxide in its clot-preventing capability.

"This may have interesting applications in a wide range of biomedical device coatings," said Teng Xue, the study's lead author and a UCLA graduate student.

"This work demonstrates how the exploration of nanomaterials, combined with knowledge in chemical catalysis and biochemistry can lead to unique functional structures benefiting biomedical research and beyond," said principal author Yu Huang, an associate professor of materials science and engineering at the UCLA Henry Samueli School of Engineering and Applied Science. "We will continue to explore molecular assemblies and conjugated catalytic systems as analogs to the functional proteins that can facilitate chemical transformations under mild conditions, like nature does."

Additional authors of the research included Mark E. Meyerhoff, professor of chemistry at the University of Michigan; UCLA graduate students Bo Peng, Si Yang, Min Xue, Xing Zhong, Shan Jiang, Sergey Dubin, Chin-Yi Chiu and Lingyan Ruan; UCLA postdoctoral scholar Yongquan Qu; and professors Jeffrey Zink, Richard Kaner and Xiangfeng Duan of the UCLA Department of Chemistry and Biochemistry. Huang, Duan, Kaner and Zink are all members of the California NanoSystems Institute at UCLA. Duan holds UCLA's Howard Reiss Career Development Chair in Chemistry and Biochemistry.

The research was supported by grants from the National Institutes of Health.

####

About University of California - Los Angeles

The UCLA Henry Samueli School of Engineering and Applied Science, established in 1945, offers 28 academic and professional degree programs and has an enrollment of more than 5,000 students. The school's distinguished faculty are leading research to address many of the critical challenges of the 21st century, including renewable energy, clean water, health care, wireless sensing and networking, and cyber-security. Ranked among the top 10 engineering schools at public universities nationwide, the school is home to eight multimillion-dollar interdisciplinary research centers in wireless sensor systems, wireless health, nanoelectronics, nanomedicine, renewable energy, customized computing, the smart grid, and the Internet, all funded by federal and private agencies and individual donors.

For more news, visit the UCLA Newsroom and follow us on Twitter.

For more information, please click here

Contacts:
Bill Kisliuk
310-206-0540


Matthew Chin
310-206-0680

Copyright © University of California - Los Angeles

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article:

Related News Press

News and information

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

Solving molybdenum disulfide's 'thin' problem: Research team increases material's light emission by twelve times March 29th, 2015

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Graphene

Graphene reduces wear of alumina ceramic March 26th, 2015

Square ice filling for a graphene sandwich March 26th, 2015

Application of Graphene Oxide in Body Implants in Iran March 26th, 2015

Haydale Announce Dedicated Graphene Inks Manufacturing Capability March 25th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Nanomedicine

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Graphene reduces wear of alumina ceramic March 26th, 2015

Application of Graphene Oxide in Body Implants in Iran March 26th, 2015

Nanorobotic agents open the blood-brain barrier, offering hope for new brain treatments March 25th, 2015

Discoveries

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

Solving molybdenum disulfide's 'thin' problem: Research team increases material's light emission by twelve times March 29th, 2015

A first glimpse inside a macroscopic quantum state March 28th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Announcements

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

Solving molybdenum disulfide's 'thin' problem: Research team increases material's light emission by twelve times March 29th, 2015

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE