Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Researchers create coating material to prevent blood clots associated with implanted devices

Abstract:
A team of researchers from UCLA and the University of Michigan has developed a material that could help prevent blood clots associated with catheters, heart valves, vascular grafts and other implanted biomedical devices.

Researchers create coating material to prevent blood clots associated with implanted devices

Los Angeles, CA | Posted on March 1st, 2014

Blood clots at or near implanted devices are thought to occur when the flow of nitric oxide, a naturally occurring clot-preventing agent generated in the blood vessels, is cut off. When this occurs, the devices can fail.

Some researchers have sought to solve this problem with implantable devices that gradually release nitric oxide, but their supply of the agent is necessarily limited. Instead, the UCLA-Michigan team focused on an ultra-thin coating for the devices that acts as a chemical catalyst, generating clot-preventing molecules that can mimic the function of blood vessels.

The researchers suggest this could offer a long-lasting and cost-effective solution to the problem of these blood clots. The study was published online this month in the journal Nature Communications.

For the device coating, the team used sheets of graphene, a one-atom-thick layer of graphitic carbon, into which they integrated two components — haemin and glucose oxidase. Both work synergistically to catalyze the production of nitroxyl, which can be used inside the blood like nitric oxide, although it contains one less electron. Nitroxyl has been reported as being analogous to nitric oxide in its clot-preventing capability.

"This may have interesting applications in a wide range of biomedical device coatings," said Teng Xue, the study's lead author and a UCLA graduate student.

"This work demonstrates how the exploration of nanomaterials, combined with knowledge in chemical catalysis and biochemistry can lead to unique functional structures benefiting biomedical research and beyond," said principal author Yu Huang, an associate professor of materials science and engineering at the UCLA Henry Samueli School of Engineering and Applied Science. "We will continue to explore molecular assemblies and conjugated catalytic systems as analogs to the functional proteins that can facilitate chemical transformations under mild conditions, like nature does."

Additional authors of the research included Mark E. Meyerhoff, professor of chemistry at the University of Michigan; UCLA graduate students Bo Peng, Si Yang, Min Xue, Xing Zhong, Shan Jiang, Sergey Dubin, Chin-Yi Chiu and Lingyan Ruan; UCLA postdoctoral scholar Yongquan Qu; and professors Jeffrey Zink, Richard Kaner and Xiangfeng Duan of the UCLA Department of Chemistry and Biochemistry. Huang, Duan, Kaner and Zink are all members of the California NanoSystems Institute at UCLA. Duan holds UCLA's Howard Reiss Career Development Chair in Chemistry and Biochemistry.

The research was supported by grants from the National Institutes of Health.

####

About University of California - Los Angeles

The UCLA Henry Samueli School of Engineering and Applied Science, established in 1945, offers 28 academic and professional degree programs and has an enrollment of more than 5,000 students. The school's distinguished faculty are leading research to address many of the critical challenges of the 21st century, including renewable energy, clean water, health care, wireless sensing and networking, and cyber-security. Ranked among the top 10 engineering schools at public universities nationwide, the school is home to eight multimillion-dollar interdisciplinary research centers in wireless sensor systems, wireless health, nanoelectronics, nanomedicine, renewable energy, customized computing, the smart grid, and the Internet, all funded by federal and private agencies and individual donors.

For more news, visit the UCLA Newsroom and follow us on Twitter.

For more information, please click here

Contacts:
Bill Kisliuk
310-206-0540


Matthew Chin
310-206-0680

Copyright © University of California - Los Angeles

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article:

Related News Press

News and information

SEMATECH to Showcase Innovation and Advances in Manufacturing at SEMICON Japan 2014: SEMATECH experts will share the latest techniques, emerging trends and best practices in advanced manufacturing strategies and methodologies November 26th, 2014

Australian startup creates world’s first 100% cotton hydrophobic T-Shirts November 26th, 2014

The mysterious 'action at a distance' between liquid containers November 26th, 2014

'Giant' charge density disturbances discovered in nanomaterials: Juelich researchers amplify Friedel oscillations in thin metallic films November 26th, 2014

Graphene

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Researchers engineer improvements of technology used in digital memory November 24th, 2014

Graphene/nanotube hybrid benefits flexible solar cells: Rice University labs create novel electrode for dye-sensitized cells November 17th, 2014

Graphene Frontiers Partners with Madico to Accelerate Material Production: Deal to ignite and fulfill demand for industrial scale graphene film that supports energy, consumer electronics, membranes/filtration, solar and other applications November 12th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Lawrence Livermore researchers develop efficient method to produce nanoporous metals November 25th, 2014

Renishaw receives Queen's Award for spectroscopy developments November 25th, 2014

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Nanomedicine

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

ASU, IBM move ultrafast, low-cost DNA sequencing technology a step closer to reality November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Discoveries

The mysterious 'action at a distance' between liquid containers November 26th, 2014

'Giant' charge density disturbances discovered in nanomaterials: Juelich researchers amplify Friedel oscillations in thin metallic films November 26th, 2014

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Announcements

SEMATECH to Showcase Innovation and Advances in Manufacturing at SEMICON Japan 2014: SEMATECH experts will share the latest techniques, emerging trends and best practices in advanced manufacturing strategies and methodologies November 26th, 2014

Australian startup creates world’s first 100% cotton hydrophobic T-Shirts November 26th, 2014

The mysterious 'action at a distance' between liquid containers November 26th, 2014

'Giant' charge density disturbances discovered in nanomaterials: Juelich researchers amplify Friedel oscillations in thin metallic films November 26th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE