Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Researchers create coating material to prevent blood clots associated with implanted devices

Abstract:
A team of researchers from UCLA and the University of Michigan has developed a material that could help prevent blood clots associated with catheters, heart valves, vascular grafts and other implanted biomedical devices.

Researchers create coating material to prevent blood clots associated with implanted devices

Los Angeles, CA | Posted on March 1st, 2014

Blood clots at or near implanted devices are thought to occur when the flow of nitric oxide, a naturally occurring clot-preventing agent generated in the blood vessels, is cut off. When this occurs, the devices can fail.

Some researchers have sought to solve this problem with implantable devices that gradually release nitric oxide, but their supply of the agent is necessarily limited. Instead, the UCLA-Michigan team focused on an ultra-thin coating for the devices that acts as a chemical catalyst, generating clot-preventing molecules that can mimic the function of blood vessels.

The researchers suggest this could offer a long-lasting and cost-effective solution to the problem of these blood clots. The study was published online this month in the journal Nature Communications.

For the device coating, the team used sheets of graphene, a one-atom-thick layer of graphitic carbon, into which they integrated two components — haemin and glucose oxidase. Both work synergistically to catalyze the production of nitroxyl, which can be used inside the blood like nitric oxide, although it contains one less electron. Nitroxyl has been reported as being analogous to nitric oxide in its clot-preventing capability.

"This may have interesting applications in a wide range of biomedical device coatings," said Teng Xue, the study's lead author and a UCLA graduate student.

"This work demonstrates how the exploration of nanomaterials, combined with knowledge in chemical catalysis and biochemistry can lead to unique functional structures benefiting biomedical research and beyond," said principal author Yu Huang, an associate professor of materials science and engineering at the UCLA Henry Samueli School of Engineering and Applied Science. "We will continue to explore molecular assemblies and conjugated catalytic systems as analogs to the functional proteins that can facilitate chemical transformations under mild conditions, like nature does."

Additional authors of the research included Mark E. Meyerhoff, professor of chemistry at the University of Michigan; UCLA graduate students Bo Peng, Si Yang, Min Xue, Xing Zhong, Shan Jiang, Sergey Dubin, Chin-Yi Chiu and Lingyan Ruan; UCLA postdoctoral scholar Yongquan Qu; and professors Jeffrey Zink, Richard Kaner and Xiangfeng Duan of the UCLA Department of Chemistry and Biochemistry. Huang, Duan, Kaner and Zink are all members of the California NanoSystems Institute at UCLA. Duan holds UCLA's Howard Reiss Career Development Chair in Chemistry and Biochemistry.

The research was supported by grants from the National Institutes of Health.

####

About University of California - Los Angeles

The UCLA Henry Samueli School of Engineering and Applied Science, established in 1945, offers 28 academic and professional degree programs and has an enrollment of more than 5,000 students. The school's distinguished faculty are leading research to address many of the critical challenges of the 21st century, including renewable energy, clean water, health care, wireless sensing and networking, and cyber-security. Ranked among the top 10 engineering schools at public universities nationwide, the school is home to eight multimillion-dollar interdisciplinary research centers in wireless sensor systems, wireless health, nanoelectronics, nanomedicine, renewable energy, customized computing, the smart grid, and the Internet, all funded by federal and private agencies and individual donors.

For more news, visit the UCLA Newsroom and follow us on Twitter.

For more information, please click here

Contacts:
Bill Kisliuk
310-206-0540


Matthew Chin
310-206-0680

Copyright © University of California - Los Angeles

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article:

Related News Press

News and information

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy August 22nd, 2014

Ultra-short pulse lasers & Positioning August 21st, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Graphene

Graphene may be key to leap in supercapacitor performance August 20th, 2014

Ultrasonic Waves Applied in Production of Graphene Nanosheets August 20th, 2014

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

New test reveals purity of graphene: Rice, Osaka scientists use terahertz waves to spot contaminants August 13th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Shaping the Future of Nanocrystals: Berkeley Lab Researchers Obtain First Direct Observation of Facet Formation in Nanocubes August 21st, 2014

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Promising Ferroelectric Materials Suffer From Unexpected Electric Polarizations: Brookhaven Lab scientists find surprising locked charge polarizations that impede performance in next-gen materials that could otherwise revolutionize data-driven devices August 18th, 2014

Nanomedicine

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

Ultra-short pulse lasers & Positioning August 21st, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Discoveries

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy August 22nd, 2014

Shaping the Future of Nanocrystals: Berkeley Lab Researchers Obtain First Direct Observation of Facet Formation in Nanocubes August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

Announcements

Tissue regeneration using anti-inflammatory nanomolecules August 22nd, 2014

A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy August 22nd, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE