Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Injured nerves regrow when fidgetin enzyme is suppressed: Fidgetin inhibition: Potential new therapeutic approach to promote tissue regeneration & repair of broken cell connections

Abstract:
Suppressing the enzyme fidgetin promotes the re-growth of experimentally injured nerve cells and their connections, according to research with laboratory rats that will be presented Tuesday, Dec. 17, at the American Society for Cell Biology (ASCB) annual meeting in New Orleans.

Injured nerves regrow when fidgetin enzyme is suppressed: Fidgetin inhibition: Potential new therapeutic approach to promote tissue regeneration & repair of broken cell connections

Bethesda, MD | Posted on December 17th, 2013

If additional studies confirm these results, fidgetin inhibition could be a potential new therapeutic approach to promote tissue regeneration and repair of the broken cell connections that occur in a wide range of conditions including myocardial infarction, or heart attack, chronic cutaneous wounds and spinal cord injury.

To explore the enzyme's role in neurons, Peter Baas, Ph.D., Lanfranco Leo and colleagues at Drexel University in Philadelphia collaborated with David Sharp, Ph.D., of Albert Einstein College of Medicine in Bronx, NY.

Dr. Sharp was the first scientist to determine that during growth and development, fidgetin prunes unstable microtubule scaffolding in cells. Microtubules hold up a cell's cytoskeleton.

Fidgetin also prunes unneeded connections in the neuronal network as it grows in complexity and size during childhood and adolescence.

The ability of nerves to grow and prune diminishes as individuals mature. As a result, neurons of adults have lost most of the power to reshape themselves. This characteristic is good for the hard wiring of the nervous system but a bitter pill because adult nerves that are badly injured or severed will not regenerate.

To determine whether fidgetin prevents nerve regrowth in the adult brain, the researchers used a novel nanoparticle technology to block the enzyme in the injured nerves of adult rats. By blocking fidgetin, they were able to restart growth in the animal model, a finding with potential implications for many types of human nerve injury, including the most difficult challenge, spinal cord injury.

The nanoparticle technology was developed by Joel Friedman, M.D., Ph.D., and Adam Friedman, M.D., of Albert Einstein College of Medicine. The tiny nanoparticles were infused with siRNA, small interfering RNA, that bound the messenger RNA (mRNA) transcribed from the fidgetin gene. The siRNA binding caused the mRNA to be tagged for destruction. As a result, the mRNA for fidgetin was not translated, and the fidgetin enzyme was not produced by the cell.

This study builds on Dr. Sharp's other research that showed that inhibiting fidgetin might help the healing of wounds, such as skin burns as well as heart tissue damaged by a heart attack.

"Depleting novel microtubule-related proteins represents a new and proprietary approach," according to the researchers, who have formed a biotech company, MicroCures Inc., to commercialize their approach. Among its potential uses, they said, would be "tissue regeneration and repair in a wide range of therapeutic contexts including: spinal cord injury, myocardial infarction, and acute and chronic cutaneous wounds."

The enzyme fidgetin is the protein product of the fidgetin gene, which was first identified in a mutant strain of "fidget" mice, first bred in 1943 by Hans Grüneberg and named for their fidgety behavior.

The research was funded in part by grants to the laboratories of Drs. Baas and Sharp from the Craig H. Neilsen Foundation and the U.S. Department of Defense.

Author will present, "Fidgetin restrains axonal growth during neuronal maturation by a microtubule-based mechanism and provides a means for therapeutically enhancing regeneration of injured adult axons," on Tuesday, Dec. 17, during the 12 noon to 1:30 p.m. poster session, "Neuronal Cytoskeleton II."

Drs. Sharp and Baas are co-senior authors. Other authors are Lanfranco Leo, Timothy O. Austin, Andrew Matamoros, Wenqian Yu and Daniel R. Marenda of Drexel University.

####

For more information, please click here

Contacts:
Cathy Yarbrough

858-243-1814

John Fleischman


Peter W. Baas, Ph.D.
Drexel University College of Medicine
Philadelphia, PA
(215) 880 4226


David J. Sharp, Ph.D.
Albert Einstein College of Medicine


and

Chief Science Officer
MicroCures Inc.
Santa Cruz, CA

Copyright © American Society for Cell Biology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Tiny nanoclusters could solve big problems for lithium-ion batteries February 21st, 2017

Strem Chemicals and Dotz Nano Ltd. Sign Distribution Agreement for Graphene Quantum Dots Collaboration February 21st, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

Breakthrough with a chain of gold atoms: In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport February 20th, 2017

Govt.-Legislation/Regulation/Funding/Policy

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

Nanomedicine

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread: Leading-Edge Research Is Part of National Cancer Moonshot Initiative February 13th, 2017

Discoveries

Tiny nanoclusters could solve big problems for lithium-ion batteries February 21st, 2017

Oxford Instruments announces Dr Brad Ramshaw of Cornell University, as winner of the 2017 Lee Osheroff Richardson Science Prize February 20th, 2017

Breakthrough with a chain of gold atoms: In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport February 20th, 2017

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Announcements

Tiny nanoclusters could solve big problems for lithium-ion batteries February 21st, 2017

Strem Chemicals and Dotz Nano Ltd. Sign Distribution Agreement for Graphene Quantum Dots Collaboration February 21st, 2017

Oxford Instruments announces Dr Brad Ramshaw of Cornell University, as winner of the 2017 Lee Osheroff Richardson Science Prize February 20th, 2017

Breakthrough with a chain of gold atoms: In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport February 20th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Tiny nanoclusters could solve big problems for lithium-ion batteries February 21st, 2017

Breakthrough with a chain of gold atoms: In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport February 20th, 2017

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Military

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Graphene foam gets big and tough: Rice University's nanotube-reinforced material can be shaped, is highly conductive February 13th, 2017

Meta-lenses bring benchtop performance to small, hand-held spectrometer: Game-changing nanostructure-based lenses allow smaller devices, increased functionality February 9th, 2017

Events/Classes

Oxford Instruments announces Dr Brad Ramshaw of Cornell University, as winner of the 2017 Lee Osheroff Richardson Science Prize February 20th, 2017

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

National Space Society's Space Settlement Summit Draws Industry Leaders February 4th, 2017

Leti Presents First Results in LED Pixelization & Record Resolution for Micro-Displays at Photonics West February 3rd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project