Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Injured nerves regrow when fidgetin enzyme is suppressed: Fidgetin inhibition: Potential new therapeutic approach to promote tissue regeneration & repair of broken cell connections

Abstract:
Suppressing the enzyme fidgetin promotes the re-growth of experimentally injured nerve cells and their connections, according to research with laboratory rats that will be presented Tuesday, Dec. 17, at the American Society for Cell Biology (ASCB) annual meeting in New Orleans.

Injured nerves regrow when fidgetin enzyme is suppressed: Fidgetin inhibition: Potential new therapeutic approach to promote tissue regeneration & repair of broken cell connections

Bethesda, MD | Posted on December 17th, 2013

If additional studies confirm these results, fidgetin inhibition could be a potential new therapeutic approach to promote tissue regeneration and repair of the broken cell connections that occur in a wide range of conditions including myocardial infarction, or heart attack, chronic cutaneous wounds and spinal cord injury.

To explore the enzyme's role in neurons, Peter Baas, Ph.D., Lanfranco Leo and colleagues at Drexel University in Philadelphia collaborated with David Sharp, Ph.D., of Albert Einstein College of Medicine in Bronx, NY.

Dr. Sharp was the first scientist to determine that during growth and development, fidgetin prunes unstable microtubule scaffolding in cells. Microtubules hold up a cell's cytoskeleton.

Fidgetin also prunes unneeded connections in the neuronal network as it grows in complexity and size during childhood and adolescence.

The ability of nerves to grow and prune diminishes as individuals mature. As a result, neurons of adults have lost most of the power to reshape themselves. This characteristic is good for the hard wiring of the nervous system but a bitter pill because adult nerves that are badly injured or severed will not regenerate.

To determine whether fidgetin prevents nerve regrowth in the adult brain, the researchers used a novel nanoparticle technology to block the enzyme in the injured nerves of adult rats. By blocking fidgetin, they were able to restart growth in the animal model, a finding with potential implications for many types of human nerve injury, including the most difficult challenge, spinal cord injury.

The nanoparticle technology was developed by Joel Friedman, M.D., Ph.D., and Adam Friedman, M.D., of Albert Einstein College of Medicine. The tiny nanoparticles were infused with siRNA, small interfering RNA, that bound the messenger RNA (mRNA) transcribed from the fidgetin gene. The siRNA binding caused the mRNA to be tagged for destruction. As a result, the mRNA for fidgetin was not translated, and the fidgetin enzyme was not produced by the cell.

This study builds on Dr. Sharp's other research that showed that inhibiting fidgetin might help the healing of wounds, such as skin burns as well as heart tissue damaged by a heart attack.

"Depleting novel microtubule-related proteins represents a new and proprietary approach," according to the researchers, who have formed a biotech company, MicroCures Inc., to commercialize their approach. Among its potential uses, they said, would be "tissue regeneration and repair in a wide range of therapeutic contexts including: spinal cord injury, myocardial infarction, and acute and chronic cutaneous wounds."

The enzyme fidgetin is the protein product of the fidgetin gene, which was first identified in a mutant strain of "fidget" mice, first bred in 1943 by Hans Grüneberg and named for their fidgety behavior.

The research was funded in part by grants to the laboratories of Drs. Baas and Sharp from the Craig H. Neilsen Foundation and the U.S. Department of Defense.

Author will present, "Fidgetin restrains axonal growth during neuronal maturation by a microtubule-based mechanism and provides a means for therapeutically enhancing regeneration of injured adult axons," on Tuesday, Dec. 17, during the 12 noon to 1:30 p.m. poster session, "Neuronal Cytoskeleton II."

Drs. Sharp and Baas are co-senior authors. Other authors are Lanfranco Leo, Timothy O. Austin, Andrew Matamoros, Wenqian Yu and Daniel R. Marenda of Drexel University.

####

For more information, please click here

Contacts:
Cathy Yarbrough

858-243-1814

John Fleischman


Peter W. Baas, Ph.D.
Drexel University College of Medicine
Philadelphia, PA
(215) 880 4226


David J. Sharp, Ph.D.
Albert Einstein College of Medicine


and

Chief Science Officer
MicroCures Inc.
Santa Cruz, CA

Copyright © American Society for Cell Biology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

MEMS & Sensors Technology Showcase: Finalists Announced for MEMS Executive Congress US 2014 October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Novel Rocket Design Flight Tested: New Rocket Propellant and Motor Design Offers High Performance and Safety October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Discoveries

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Military

NanoTechnology for Defense (NT4D) October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

1980s aircraft helps quantum technology take flight October 20th, 2014

Events/Classes

Iran-Made Respiratory Nano Masks Provided to Hajj Pilgrims October 23rd, 2014

MEMS & Sensors Technology Showcase: Finalists Announced for MEMS Executive Congress US 2014 October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

NanoTechnology for Defense (NT4D) October 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE