Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Team Led by Professor Jingyue Ju Wins $5.25 Million NIH Grant to Develop a New Single Molecule Electronic DNA Sequencing Platform

Abstract:
A team of researchers led by Jingyue Ju, Samuel Ruben-Peter G. Viele Professor of Engineering at Columbia University's Fu Foundation School of Engineering and Applied Science, has won a three-year $5.25 million grant from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), to develop a novel integrated miniaturized system for real-time single molecule electronic DNA sequencing. The award is the largest of NHGRI's most recent $17 million initiative to support development of innovative technologies with the potential to dramatically reduce the cost of DNA sequencing, so that sequencing an individual's genome can become a routine part of medical research and health care.

Team Led by Professor Jingyue Ju Wins $5.25 Million NIH Grant to Develop a New Single Molecule Electronic DNA Sequencing Platform

New York, NY | Posted on September 13th, 2013

The team includes researchers from Columbia University and its collaborative institutions: Harvard University, Genia Technologies, Inc., and the National Institute of Standards and Technology (NIST). Under the direction of Ju, who is also Professor of Chemical Engineering and Pharmacology and Director of Columbia Engineering's Center for Genome Technology and Biomolecular Engineering, the team aims to use nucleic acid chemistry, electronics, and protein engineering to develop a NanoTag single molecule electronic DNA sequencing approach, which includes the design and synthesis of four nucleotide analogs (modified building blocks of DNA) labeled at the 5'-terminal phosphate with distinct polymer tags. These tagged-nucleotides will elicit well-differentiated electrical current blockade signals as they enter nanopores under an applied voltage during polymerase reaction for DNA sequence determination. The investigators will assemble large arrays of the nanopores, each with an attached polymerase, to create DNA sequencing chips. The addition of the primed DNA template and the four tagged-nucleotides to the nanopore-chip will allow high accuracy single molecule electronic sequencing by synthesis in real time.

"Our research and development efforts in DNA sequencing technologies have been generously supported by the NIH for over a decade. This has led to the development of a four-color DNA sequencing by synthesis platform using cleavable fluorescent nucleotide reversible terminators, which is the dominant approach used in the next generation DNA sequencing systems," says Ju. "This new NHGRI grant provides timely support for our consortium to develop the NanoTag single molecule electronic DNA sequencing approach into a robust miniaturized platform that will eventually allow the entire human genome to be deciphered for about $100. The enhanced accuracy, scalability, and flexibility of this technology will make it an ideal platform for personalized medicine and basic biomedical research."

The other key researchers for the Columbia Engineering-led research consortium include George Church, Professor of Genetics, Harvard University Medical School; James Russo, Associate Director of the Center for Genome Technology and Biomolecular Engineering, and Ken Shepard, Professor of Electrical and Biomedical Engineering, both at Columbia; John Kasianowicz, fellow of the American Physical Society, at NIST; and Stefan Roever, CEO of Genia.

####

About Columbia Engineering
Columbia University's Fu Foundation School of Engineering and Applied Science, founded in 1864, offers programs in nine departments to both undergraduate and graduate students. With facilities specifically designed and equipped to meet the laboratory and research needs of faculty and students, Columbia Engineering is home to NSF-NIH funded centers in genomic science, molecular nanostructures, materials science, and energy, as well as one of the worldís leading programs in financial engineering. These interdisciplinary centers are leading the way in their respective fields while individual groups of engineers and scientists collaborate to solve some of modern societyís more difficult challenges.

For more information, please click here

Contacts:
Holly Evarts
Director
Strategic Communications and Media Relations
212-854-3206 (o)
347-453-7408 (c)

Copyright © Columbia Engineering

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A step closer to understanding quantum mechanics: Swansea Universityís physicists develop a new quantum simulation protocol October 22nd, 2017

Creation of coherent states in molecules by incoherent electrons October 21st, 2017

Strange but true: turning a material upside down can sometimes make it softer October 20th, 2017

Leti Coordinating Project to Develop Innovative Drivetrains for 3rd-generation Electric Vehicles: CEA Techís Contribution Includes Litenís Knowhow in Magnetic Materials and Simulation And Letiís Expertise in Wide-bandgap Semiconductors October 20th, 2017

Govt.-Legislation/Regulation/Funding/Policy

Leti Coordinating Project to Develop Innovative Drivetrains for 3rd-generation Electric Vehicles: CEA Techís Contribution Includes Litenís Knowhow in Magnetic Materials and Simulation And Letiís Expertise in Wide-bandgap Semiconductors October 20th, 2017

Bringing the atomic world into full color: Researchers turn atomic force microscope measurements into color images October 19th, 2017

Long nanotubes make strong fibers: Rice University researchers advance characterization, purification of nanotube wires and films October 17th, 2017

Spinning strands hint at folding dynamics: Rice University lab uses magnetic beads to model microscopic proteins, polymers October 17th, 2017

Nanomedicine

Spinning strands hint at folding dynamics: Rice University lab uses magnetic beads to model microscopic proteins, polymers October 17th, 2017

Arrowhead Pharmaceuticals to Present Preclinical Data on ARO-AAT at The Liver Meeting(R) October 10th, 2017

Arrowhead to Present at Chardan Gene Therapy Conference October 3rd, 2017

'CRISPR-Gold' fixes Duchenne muscular dystrophy mutation in mice October 3rd, 2017

Discoveries

A step closer to understanding quantum mechanics: Swansea Universityís physicists develop a new quantum simulation protocol October 22nd, 2017

Creation of coherent states in molecules by incoherent electrons October 21st, 2017

Novel 'converter' heralds breakthrough in ultra-fast data processing at nanoscale: Invention bagged four patents and could potentially make microprocessor chips work 1,000 times faster October 20th, 2017

Strange but true: turning a material upside down can sometimes make it softer October 20th, 2017

Announcements

A step closer to understanding quantum mechanics: Swansea Universityís physicists develop a new quantum simulation protocol October 22nd, 2017

Creation of coherent states in molecules by incoherent electrons October 21st, 2017

Strange but true: turning a material upside down can sometimes make it softer October 20th, 2017

Leti Coordinating Project to Develop Innovative Drivetrains for 3rd-generation Electric Vehicles: CEA Techís Contribution Includes Litenís Knowhow in Magnetic Materials and Simulation And Letiís Expertise in Wide-bandgap Semiconductors October 20th, 2017

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Novel 'converter' heralds breakthrough in ultra-fast data processing at nanoscale: Invention bagged four patents and could potentially make microprocessor chips work 1,000 times faster October 20th, 2017

Bringing the atomic world into full color: Researchers turn atomic force microscope measurements into color images October 19th, 2017

Long nanotubes make strong fibers: Rice University researchers advance characterization, purification of nanotube wires and films October 17th, 2017

Rice U. study: Vibrating nanoparticles interact: Placing nanodisks in groups can change their vibrational frequencies October 16th, 2017

Nanobiotechnology

Spinning strands hint at folding dynamics: Rice University lab uses magnetic beads to model microscopic proteins, polymers October 17th, 2017

Arrowhead Pharmaceuticals to Present Preclinical Data on ARO-AAT at The Liver Meeting(R) October 10th, 2017

Arrowhead to Present at Chardan Gene Therapy Conference October 3rd, 2017

'CRISPR-Gold' fixes Duchenne muscular dystrophy mutation in mice October 3rd, 2017

Research partnerships

Novel 'converter' heralds breakthrough in ultra-fast data processing at nanoscale: Invention bagged four patents and could potentially make microprocessor chips work 1,000 times faster October 20th, 2017

Strange but true: turning a material upside down can sometimes make it softer October 20th, 2017

Leti Coordinating Project to Develop Innovative Drivetrains for 3rd-generation Electric Vehicles: CEA Techís Contribution Includes Litenís Knowhow in Magnetic Materials and Simulation And Letiís Expertise in Wide-bandgap Semiconductors October 20th, 2017

Bringing the atomic world into full color: Researchers turn atomic force microscope measurements into color images October 19th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project