Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Team Led by Professor Jingyue Ju Wins $5.25 Million NIH Grant to Develop a New Single Molecule Electronic DNA Sequencing Platform

Abstract:
A team of researchers led by Jingyue Ju, Samuel Ruben-Peter G. Viele Professor of Engineering at Columbia University's Fu Foundation School of Engineering and Applied Science, has won a three-year $5.25 million grant from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), to develop a novel integrated miniaturized system for real-time single molecule electronic DNA sequencing. The award is the largest of NHGRI's most recent $17 million initiative to support development of innovative technologies with the potential to dramatically reduce the cost of DNA sequencing, so that sequencing an individual's genome can become a routine part of medical research and health care.

Team Led by Professor Jingyue Ju Wins $5.25 Million NIH Grant to Develop a New Single Molecule Electronic DNA Sequencing Platform

New York, NY | Posted on September 13th, 2013

The team includes researchers from Columbia University and its collaborative institutions: Harvard University, Genia Technologies, Inc., and the National Institute of Standards and Technology (NIST). Under the direction of Ju, who is also Professor of Chemical Engineering and Pharmacology and Director of Columbia Engineering's Center for Genome Technology and Biomolecular Engineering, the team aims to use nucleic acid chemistry, electronics, and protein engineering to develop a NanoTag single molecule electronic DNA sequencing approach, which includes the design and synthesis of four nucleotide analogs (modified building blocks of DNA) labeled at the 5'-terminal phosphate with distinct polymer tags. These tagged-nucleotides will elicit well-differentiated electrical current blockade signals as they enter nanopores under an applied voltage during polymerase reaction for DNA sequence determination. The investigators will assemble large arrays of the nanopores, each with an attached polymerase, to create DNA sequencing chips. The addition of the primed DNA template and the four tagged-nucleotides to the nanopore-chip will allow high accuracy single molecule electronic sequencing by synthesis in real time.

"Our research and development efforts in DNA sequencing technologies have been generously supported by the NIH for over a decade. This has led to the development of a four-color DNA sequencing by synthesis platform using cleavable fluorescent nucleotide reversible terminators, which is the dominant approach used in the next generation DNA sequencing systems," says Ju. "This new NHGRI grant provides timely support for our consortium to develop the NanoTag single molecule electronic DNA sequencing approach into a robust miniaturized platform that will eventually allow the entire human genome to be deciphered for about $100. The enhanced accuracy, scalability, and flexibility of this technology will make it an ideal platform for personalized medicine and basic biomedical research."

The other key researchers for the Columbia Engineering-led research consortium include George Church, Professor of Genetics, Harvard University Medical School; James Russo, Associate Director of the Center for Genome Technology and Biomolecular Engineering, and Ken Shepard, Professor of Electrical and Biomedical Engineering, both at Columbia; John Kasianowicz, fellow of the American Physical Society, at NIST; and Stefan Roever, CEO of Genia.

####

About Columbia Engineering
Columbia University's Fu Foundation School of Engineering and Applied Science, founded in 1864, offers programs in nine departments to both undergraduate and graduate students. With facilities specifically designed and equipped to meet the laboratory and research needs of faculty and students, Columbia Engineering is home to NSF-NIH funded centers in genomic science, molecular nanostructures, materials science, and energy, as well as one of the world’s leading programs in financial engineering. These interdisciplinary centers are leading the way in their respective fields while individual groups of engineers and scientists collaborate to solve some of modern society’s more difficult challenges.

For more information, please click here

Contacts:
Holly Evarts
Director
Strategic Communications and Media Relations
212-854-3206 (o)
347-453-7408 (c)

Copyright © Columbia Engineering

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Nanomedicine

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Discoveries

Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Announcements

Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Physicists decipher electronic properties of materials in work that may change transistors December 6th, 2016

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Nanobiotechnology

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

Research partnerships

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project