Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Team Led by Professor Jingyue Ju Wins $5.25 Million NIH Grant to Develop a New Single Molecule Electronic DNA Sequencing Platform

Abstract:
A team of researchers led by Jingyue Ju, Samuel Ruben-Peter G. Viele Professor of Engineering at Columbia University's Fu Foundation School of Engineering and Applied Science, has won a three-year $5.25 million grant from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), to develop a novel integrated miniaturized system for real-time single molecule electronic DNA sequencing. The award is the largest of NHGRI's most recent $17 million initiative to support development of innovative technologies with the potential to dramatically reduce the cost of DNA sequencing, so that sequencing an individual's genome can become a routine part of medical research and health care.

Team Led by Professor Jingyue Ju Wins $5.25 Million NIH Grant to Develop a New Single Molecule Electronic DNA Sequencing Platform

New York, NY | Posted on September 13th, 2013

The team includes researchers from Columbia University and its collaborative institutions: Harvard University, Genia Technologies, Inc., and the National Institute of Standards and Technology (NIST). Under the direction of Ju, who is also Professor of Chemical Engineering and Pharmacology and Director of Columbia Engineering's Center for Genome Technology and Biomolecular Engineering, the team aims to use nucleic acid chemistry, electronics, and protein engineering to develop a NanoTag single molecule electronic DNA sequencing approach, which includes the design and synthesis of four nucleotide analogs (modified building blocks of DNA) labeled at the 5'-terminal phosphate with distinct polymer tags. These tagged-nucleotides will elicit well-differentiated electrical current blockade signals as they enter nanopores under an applied voltage during polymerase reaction for DNA sequence determination. The investigators will assemble large arrays of the nanopores, each with an attached polymerase, to create DNA sequencing chips. The addition of the primed DNA template and the four tagged-nucleotides to the nanopore-chip will allow high accuracy single molecule electronic sequencing by synthesis in real time.

"Our research and development efforts in DNA sequencing technologies have been generously supported by the NIH for over a decade. This has led to the development of a four-color DNA sequencing by synthesis platform using cleavable fluorescent nucleotide reversible terminators, which is the dominant approach used in the next generation DNA sequencing systems," says Ju. "This new NHGRI grant provides timely support for our consortium to develop the NanoTag single molecule electronic DNA sequencing approach into a robust miniaturized platform that will eventually allow the entire human genome to be deciphered for about $100. The enhanced accuracy, scalability, and flexibility of this technology will make it an ideal platform for personalized medicine and basic biomedical research."

The other key researchers for the Columbia Engineering-led research consortium include George Church, Professor of Genetics, Harvard University Medical School; James Russo, Associate Director of the Center for Genome Technology and Biomolecular Engineering, and Ken Shepard, Professor of Electrical and Biomedical Engineering, both at Columbia; John Kasianowicz, fellow of the American Physical Society, at NIST; and Stefan Roever, CEO of Genia.

####

About Columbia Engineering
Columbia University's Fu Foundation School of Engineering and Applied Science, founded in 1864, offers programs in nine departments to both undergraduate and graduate students. With facilities specifically designed and equipped to meet the laboratory and research needs of faculty and students, Columbia Engineering is home to NSF-NIH funded centers in genomic science, molecular nanostructures, materials science, and energy, as well as one of the world’s leading programs in financial engineering. These interdisciplinary centers are leading the way in their respective fields while individual groups of engineers and scientists collaborate to solve some of modern society’s more difficult challenges.

For more information, please click here

Contacts:
Holly Evarts
Director
Strategic Communications and Media Relations
212-854-3206 (o)
347-453-7408 (c)

Copyright © Columbia Engineering

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Dolomite to launch Meros TCU-100 temperature controller at Lab-on-a-Chip & Microarray World Congress September 15th, 2014

Fonon at Cutting-Edge of 3D Military Printing: Live-Combat Scenarios Could See a Decisive Advantage with 3D Printing September 15th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Simple, Cost-Effective Method Proposed for Synthesizing Zinc Oxide Nanopigments September 15th, 2014

Govt.-Legislation/Regulation/Funding/Policy

'Squid skin' metamaterials project yields vivid color display: Rice lab creates RGB color display technology with aluminum nanorods September 15th, 2014

Fonon at Cutting-Edge of 3D Military Printing: Live-Combat Scenarios Could See a Decisive Advantage with 3D Printing September 15th, 2014

Seeking Nanoscale Defenses for Biological and Chemical Threats: WPI co-organizes a NATO workshop to improve the detection and decontamination of biological and chemical agents September 13th, 2014

Berkeley Lab Licenses Boron Nitride Nanotube Technology: New material has unique mechanical and electronic properties September 13th, 2014

Nanomedicine

Treatment of Cell Infection by Nanotechnology September 15th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

Iranian Scientists Discover Nanotechnology Method to Remove Limitations in Tumor Surgery September 11th, 2014

Iranian Nanotechnology Scientists Produce Polymeric Scaffolds for Tissue Engineering September 11th, 2014

Discoveries

Elusive Quantum Transformations Found Near Absolute Zero: Brookhaven Lab and Stony Brook University researchers measured the quantum fluctuations behind a novel magnetic material's ultra-cold ferromagnetic phase transition September 15th, 2014

'Squid skin' metamaterials project yields vivid color display: Rice lab creates RGB color display technology with aluminum nanorods September 15th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Simple, Cost-Effective Method Proposed for Synthesizing Zinc Oxide Nanopigments September 15th, 2014

Announcements

Dolomite to launch Meros TCU-100 temperature controller at Lab-on-a-Chip & Microarray World Congress September 15th, 2014

Fonon at Cutting-Edge of 3D Military Printing: Live-Combat Scenarios Could See a Decisive Advantage with 3D Printing September 15th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Simple, Cost-Effective Method Proposed for Synthesizing Zinc Oxide Nanopigments September 15th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Elusive Quantum Transformations Found Near Absolute Zero: Brookhaven Lab and Stony Brook University researchers measured the quantum fluctuations behind a novel magnetic material's ultra-cold ferromagnetic phase transition September 15th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

First Colloid and Polymer Science Lecture awarded to Orlin D. Velev: Chemical engineer honored for outstanding research in colloid science September 12th, 2014

Advanced Light Source Sets Microscopy Record| Berkeley Lab Researchers Achieve Highest Resolution Ever with X-ray Microscopy September 11th, 2014

Nanobiotechnology

NanoStruck has a High Recovery Rate on Mine Tailings: retrieval of up to 96% of Gold, 88% of Silver and 86% of Palladium September 12th, 2014

Boosting armor for nuclear-waste eating microbes September 12th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

Research partnerships

Elusive Quantum Transformations Found Near Absolute Zero: Brookhaven Lab and Stony Brook University researchers measured the quantum fluctuations behind a novel magnetic material's ultra-cold ferromagnetic phase transition September 15th, 2014

NEI Corporation and PneumatiCoat Technologies Sign Agreement to Jointly Develop and Market New Materials for Lithium-ion Batteries September 12th, 2014

Advanced Light Source Sets Microscopy Record| Berkeley Lab Researchers Achieve Highest Resolution Ever with X-ray Microscopy September 11th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE