Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Team Led by Professor Jingyue Ju Wins $5.25 Million NIH Grant to Develop a New Single Molecule Electronic DNA Sequencing Platform

Abstract:
A team of researchers led by Jingyue Ju, Samuel Ruben-Peter G. Viele Professor of Engineering at Columbia University's Fu Foundation School of Engineering and Applied Science, has won a three-year $5.25 million grant from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), to develop a novel integrated miniaturized system for real-time single molecule electronic DNA sequencing. The award is the largest of NHGRI's most recent $17 million initiative to support development of innovative technologies with the potential to dramatically reduce the cost of DNA sequencing, so that sequencing an individual's genome can become a routine part of medical research and health care.

Team Led by Professor Jingyue Ju Wins $5.25 Million NIH Grant to Develop a New Single Molecule Electronic DNA Sequencing Platform

New York, NY | Posted on September 13th, 2013

The team includes researchers from Columbia University and its collaborative institutions: Harvard University, Genia Technologies, Inc., and the National Institute of Standards and Technology (NIST). Under the direction of Ju, who is also Professor of Chemical Engineering and Pharmacology and Director of Columbia Engineering's Center for Genome Technology and Biomolecular Engineering, the team aims to use nucleic acid chemistry, electronics, and protein engineering to develop a NanoTag single molecule electronic DNA sequencing approach, which includes the design and synthesis of four nucleotide analogs (modified building blocks of DNA) labeled at the 5'-terminal phosphate with distinct polymer tags. These tagged-nucleotides will elicit well-differentiated electrical current blockade signals as they enter nanopores under an applied voltage during polymerase reaction for DNA sequence determination. The investigators will assemble large arrays of the nanopores, each with an attached polymerase, to create DNA sequencing chips. The addition of the primed DNA template and the four tagged-nucleotides to the nanopore-chip will allow high accuracy single molecule electronic sequencing by synthesis in real time.

"Our research and development efforts in DNA sequencing technologies have been generously supported by the NIH for over a decade. This has led to the development of a four-color DNA sequencing by synthesis platform using cleavable fluorescent nucleotide reversible terminators, which is the dominant approach used in the next generation DNA sequencing systems," says Ju. "This new NHGRI grant provides timely support for our consortium to develop the NanoTag single molecule electronic DNA sequencing approach into a robust miniaturized platform that will eventually allow the entire human genome to be deciphered for about $100. The enhanced accuracy, scalability, and flexibility of this technology will make it an ideal platform for personalized medicine and basic biomedical research."

The other key researchers for the Columbia Engineering-led research consortium include George Church, Professor of Genetics, Harvard University Medical School; James Russo, Associate Director of the Center for Genome Technology and Biomolecular Engineering, and Ken Shepard, Professor of Electrical and Biomedical Engineering, both at Columbia; John Kasianowicz, fellow of the American Physical Society, at NIST; and Stefan Roever, CEO of Genia.

####

About Columbia Engineering
Columbia University's Fu Foundation School of Engineering and Applied Science, founded in 1864, offers programs in nine departments to both undergraduate and graduate students. With facilities specifically designed and equipped to meet the laboratory and research needs of faculty and students, Columbia Engineering is home to NSF-NIH funded centers in genomic science, molecular nanostructures, materials science, and energy, as well as one of the world’s leading programs in financial engineering. These interdisciplinary centers are leading the way in their respective fields while individual groups of engineers and scientists collaborate to solve some of modern society’s more difficult challenges.

For more information, please click here

Contacts:
Holly Evarts
Director
Strategic Communications and Media Relations
212-854-3206 (o)
347-453-7408 (c)

Copyright © Columbia Engineering

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern July 21st, 2018

World's fastest man-made spinning object could help study quantum mechanics July 20th, 2018

Relax, just break it July 20th, 2018

Future electronic components to be printed like newspapers July 20th, 2018

Govt.-Legislation/Regulation/Funding/Policy

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern July 21st, 2018

World's fastest man-made spinning object could help study quantum mechanics July 20th, 2018

Relax, just break it July 20th, 2018

Future electronic components to be printed like newspapers July 20th, 2018

Nanomedicine

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Discoveries

World's fastest man-made spinning object could help study quantum mechanics July 20th, 2018

Relax, just break it July 20th, 2018

Future electronic components to be printed like newspapers July 20th, 2018

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

Announcements

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern July 21st, 2018

World's fastest man-made spinning object could help study quantum mechanics July 20th, 2018

Relax, just break it July 20th, 2018

Future electronic components to be printed like newspapers July 20th, 2018

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern July 21st, 2018

World's fastest man-made spinning object could help study quantum mechanics July 20th, 2018

Future electronic components to be printed like newspapers July 20th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

Nanobiotechnology

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Arrowhead Presents New Clinical Data on ARO-AAT at Alpha-1 National Education Conference July 1st, 2018

Research partnerships

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern July 21st, 2018

World's fastest man-made spinning object could help study quantum mechanics July 20th, 2018

Future electronic components to be printed like newspapers July 20th, 2018

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project