Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Is that bacteria dead yet? Nano and laser technology packed into small device tests antibiotic treatment in minutes

Abstract:
Researchers at EPFL have built a matchbox-sized device that can test for the presence of bacteria in a couple of minutes, instead of up to several weeks. A nano-lever vibrates in the presence of bacterial activity, while a laser reads the vibration and translates it into an electrical signal that can be easily read—the absence of a signal signifies the absence of bacteria. Thanks to this method, it is quick and easy to determine if a bacteria has been effectively treated by an antibiotic, a crucial medical tool especially for resistant strains. Easily used in clinics, it could also prove useful for testing chemotherapy treatment. The research is published in the latest issue of Nature Nanotechnology.

Is that bacteria dead yet? Nano and laser technology packed into small device tests antibiotic treatment in minutes

Lausanne, Switzerland | Posted on July 1st, 2013

"This method is fast and accurate. And it can be a precious tool for both doctors looking for the right dosage of antibiotics and for researchers to determine which treatments are the most effective," explains Giovanni Dietler.

Laser and nanotechnology read the bacteria's metabolic activity

It currently takes a long time to measure a bacterial infection's response to antibiotic treatment. Clinicians must culture the bacteria and then observe its growth, sometimes for almost a month, as is the case with tuberculosis, in order to determine if the treatment has been effective.

Thanks to advances in laser and optical technology, the EPFL team of physicists has reduced this time to a couple of minutes. To do so, Giovanni Dietler, Sandor Kasas and Giovanni Longo have exploited the microscopic movements of a bacterium's metabolism.

These vital signs are almost unperceivable. In order to test for them, the researchers place the bacteria on an extremely sensitive measuring device that vibrates a small lever—only slightly thicker than a strand of hair—in the presence of certain activity. The lever then vibrates under the metabolic activity of the germs. These infinitely small oscillations, on the order of one millionth of a millimeter, determine the presence or absence of the bacteria.

To measure these vibrations, the researchers project a laser onto the lever. The light is then reflected back and the signal is converted into an electrical current to be interpreted by the clinician or researcher. When the electrical current is a flat line, one knows that the bacteria are all dead; it is as easy to read as an electrocardiogram.

A promising method for cancer treatment

The researchers have miniaturized the tool—it is currently the size of a matchbox. "By joining our tool with a piezoelectric device instead of a laser, we could further reduce its size to the size of a microchip," says Giovanni Dietler. They could then be combined together to test a series of antibiotics on one strain in only a couple of minutes.

The researchers are currently evaluating the tool's potential in other fields, notably oncology. They are looking into measuring the metabolism of tumor cells that have been exposed to cancer treatment to evaluate the efficiency of the treatment. "If our method also works in this field, we really have a precious tool on our hands that can allow us to develop new treatments and also test both quickly and simply how the patient is reacting to the cancer treatment," says Sandor Kasas.

####

For more information, please click here

Contacts:
Lionel Pousaz

41-795-597-161

Copyright © Ecole Polytechnique Fédérale de Lausanne

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad 2018 September 20th, 2018

Nanomedicine

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad 2018 September 20th, 2018

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Discoveries

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Announcements

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad 2018 September 20th, 2018

Photonics/Optics/Lasers

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Laser sintering optimized for printed electronics: New study sheds (laser) light on the best means of laying down thin-film circuitry September 13th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project