Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticle Delivers Large Protein Complex to Cancer Cell Nucleus

Abstract:
Drug developers have been using nanoparticles to encapsulate a wide range of molecules for delivery to tumors. Now, they can add a large protein complex to that list thanks to research from the laboratory of Yi Tang of the University of California at Los Angeles (UCLA). In a study published in the journal Nano Today, Dr. Yi and his colleagues showed that not only could their degradable nanoscale shell carry proteins to cancer cells, but that they could transport a protein complex into the cell's nucleus.

Nanoparticle Delivers Large Protein Complex to Cancer Cell Nucleus

Bethesda, MD | Posted on May 20th, 2013

The UCLA team focused their work on the protein apoptin, a large complex derived from an anemia virus in birds. When delivered to the cell nucleus, this protein cargo signals the cell to undergo programmed self-destruction. Previous work by several groups had shown that healthy cells degrade this protein in the cytoplasm, but that cancer cells add a phosphate group to the protein, which causes it to accumulate in the cell nucleus and trigger cell death.

One of the challenges to deliver apoptin is that it is a large protein complex containing 30 to 40 copies of the protein. It is thought that this complex and not an individual copy of apoptin is important to effectively trigger cell death. The UCLA team overcame this challenge by choosing a water soluble polymer that self assembles around the protein complex and that can then be stabilized using a very mild chemical reaction. The chemical bonds formed during this stabilization reaction are stable enough to keep the particle intact as it circulates through the blood stream, but weak enough to fall apart in the reducing environment inside a cell.

Studies using cancer cell lines demonstrated that tumor cells readily took up the apoptin-containing nanoparticles and that the protein complex accumulated in the cell nucleus. Subsequent experiments with tumor-bearing mice showed that this construct, when administered intravenously every other day for 12 days, had a marked effect on slowing the growth of tumors. The researchers noted that they are now developing ways to more precisely target tumors, prolong the circulation time of the nanoparticles, and deliver other potentially therapeutic proteins to cancer cells.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex."

Related News Press

News and information

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Nanomedicine

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Discoveries

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Announcements

NanoTechnology for Defense (NT4D) October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE