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Iranian researchers at the Islamic Azad University, Zanjan Branch, managed to find a new drug delivery system by attaching gold nanoparticles to gentamicin for transferring anti-bacterial drug staphylococcal to infected foci.
Innovative drug delivery methods have shown to improve the treatment of the infections caused by tuberculosis or viral diseases such as AIDS, everyday. Thanks to a number of their properties like being non-toxic in biologic systems, high surface-to-volume aspect ratio and having conjugated surfaces appropriate for bonding with bio-molecules, gold nanoparticles act as perfect carriers which are able to target the infection spots with a concentrated load of an antibacterial drug.
Experimental results have revealed the superiority of this antimicrobial nanodrug over gentamicin in fight against Staphylococcus Aureus. In addition, in vivo tests on mice suffering from the infections caused by Staphylococcus Aureus bacteria ascertained the ability of the proposed nanodrug to accumulate in high concentrations at locations where the infection level was higher and hence to accelerate the healing process.
The mentioned study paves the ground for development of similar nanodrugs for treatment of infections caused by dangerous bacteria such as Mycobacterium Tuberculosis, Brucella Melitensis (the causative agent for Malta fever) or viral infections like AIDS, Hepatitis B, etc.
The results of this research work conducted by Azam Ahangari et al has been published in Drug Delivery Journal, Vol. 20, No. 1, 2013, pages 34 to 39.
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